VOTE FOR DAVE: https://tophost.org/2026/david-knapp

The FDA just issued a NEW eye warning for EVERY GLP-1 medication, including Ozempic, Wegovy, Mounjaro, and Zepbound. But how worried should patients actually be?On today's On The Pen, we're breaking down the FDA's November 9 warning about NAION, a rare condition that can cause sudden vision loss. We'll look at what the data actually show, how rare the risk is, and what patients need to know before making decisions about their medications.PLUS, it's been a massive week in obesity medicine!💊 **Hims & Hers makes a BIG move:** As profit margins shrink and the company shifts toward branded GLP-1s, Hims announces an $8.5 million annual arrangement involving Andrew Huberman and prepares to enter the experimental peptide market.💪 **New tirzepatide research:** A randomized clinical trial shows that resistance training can significantly reduce lean tissue loss while taking Mounjaro or Zepbound.💤 **Foundayo and sleep apnea:** Eli Lilly's oral GLP-1 delivers promising Phase 3 results for patients with obstructive sleep apnea.🔬 **Retatrutide and next-generation medications:** New research on knee osteoarthritis, survodutide's cardiovascular trial, and a quadruple agonist targeting FOUR hormonal pathways.💰 **The GLP-1 affordability crisis:** As pharmaceutical companies report billions in sales, more patients are facing the loss of employer-sponsored coverage.We're talking safety, science, affordability, and what all of this means for REAL patients.**JOIN THE CONVERSATION:** Does the FDA's new eye warning change how you feel about GLP-1 medications? Let me know in the comments!🔗 **FOLLOW ON THE PEN AND FIND ALL OUR LINKS:**https://linktr.ee/manonthemounjaro📰 Latest obesity medicine news:https://onthepen.comThis content is for educational and informational purposes only. I am not a medical professional. Always consult your healthcare provider before making changes to your treatment.#GLP1 #Ozempic #Mounjaro #Zepbound #Wegovy #Retatrutide #WeightLoss #ObesityMedicine #OnThePen

What if the next big breakthrough in obesity medicine isn't a GLP-1 at all?

Novo Nordisk is developing an experimental oral weight-loss medication called LX9851, an ACSL5 inhibitor that targets an entirely different biological pathway than Ozempic, Wegovy, or Zepbound. Novo believes this once-daily pill could potentially deliver 10–15% weight loss without traditional dose titration.

But there's a catch. The drug is still in Phase 1 trials, and those weight-loss projections haven't been demonstrated in humans.

On this week's episode of On The Pen: The Weekly Dose, we're diving into Novo Nordisk's expanding obesity pipeline, the fascinating science behind the ACSL5 enzyme and the intestinal "ileal brake," and why this non-GLP-1 approach could eventually offer new options for patients who struggle with existing treatments.

We'll also examine the preclinical research, its potential alongside semaglutide, and why 2030 or later may be the earliest realistic timeline for this experimental therapy.

Could the future of obesity medicine be bigger than GLP-1s?

💬 Would you consider a weight-loss medication that doesn't directly activate GLP-1 receptors? Let me know in the comments!

🔗 All On The Pen resources, sponsors, and community links: https://linktr.ee/manonthemounjaro

🌐 Latest obesity medicine news: https://onthepen.com

🎙️ On The Pen Live: Monday, Wednesday, and Friday at 11 AM Central.

Subscribe for independent, patient-centered reporting on obesity medicine, GLP-1s, type 2 diabetes, clinical trials, and emerging metabolic therapies.

Disclaimer: LX9851 is investigational and not FDA-approved. Projected weight loss and development timelines are not established clinical outcomes. This content is for educational purposes and is not medical advice.

Retatrutide’s New Phase 3 Data, CagriSema in Menopause, and the Growing GLP‑1 Access CrisisHost Dave Knapp recaps major obesity-drug updates, focusing on Eli Lilly’s triple agonist retatrutide and Novo Nordisk’s CagriSema. He reviews Triumph 1 obesity results (up to 25% average weight loss at 80 weeks) and highlights New England Journal of Medicine Phase 3 data showing large reductions in obstructive sleep apnea events in people with and without type 2 diabetes, while noting uncertainty about weight-loss versus nervous-system mechanisms. He also covers TRANSCEND CKD Phase 2B kidney findings: no significant improvement in measured GFR, but favorable secondary markers including reduced urine albumin in a subset. Novo’s post hoc Redefine 1 analyses show strong CagriSema weight loss across pre-, peri-, and post-menopausal women. He discusses Zealand/Roche’s petrelintide Phase 2 results emphasizing low GI discontinuation and argues tolerability matters as much as potency. The episode closes on worsening affordability and coverage, including employers dropping benefits and Pennsylvania Medicaid GLP-1 spending rising to an estimated $1.3B, warning restricted access fuels the gray market.00:00 Big Week in Obesity Drugs00:53 Show Intro and Disclaimers02:03 Sponsor Spotlight VoaFit03:06 Retatrutide Weight Loss Context05:27 Sleep Apnea Phase 3 Results10:23 Beyond Weight Loss Benefits12:14 Kidney Study Nuance16:53 CagriSema Menopause Data19:20 Petrelintide Amylin Update23:33 Top Host Voting Pitch ( otplinks.com )25:29 Access and Coverage Crisis27:42 Medicaid Costs and Gray Market31:21 Wrap Up and Schedule