Drs Ursula A. Matulonis and Immaculata De Vivo discuss the epidemiology of endometrial cancer and how clinicians can use information about risk factors.

Relevant disclosures can be found with the episode show notes on Medscape https://www.medscape.com/ca8/p04/podcast-endometrial-cancer-s3-ep6-2026a10006ig. The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

Endometrial Carcinoma https://emedicine.medscape.com/article/254083-overview

Cancer Stat Facts: Uterine Cancer https://seer.cancer.gov/statfacts/html/corp.html

Risk Prediction Models for Endometrial Cancer: Development and Validation in an International Consortium https://pubmed.ncbi.nlm.nih.gov/36688725/

Genome-wide Association Study of Endometrial Cancer in E2C2 https://pubmed.ncbi.nlm.nih.gov/24096698/

Projected Trends in the Incidence and Mortality of Uterine Cancer in the United States https://pubmed.ncbi.nlm.nih.gov/40589281/

Understanding Risk Factors for Endometrial Cancer in Young Women https://pubmed.ncbi.nlm.nih.gov/39235934/

Association Between Metabolic Syndrome and Endometrial Cancer Risk: A Systematic Review and Meta-analysis of Observational Studies https://pubmed.ncbi.nlm.nih.gov/32439832/

Cigarette Smoking and Endometrial Cancer Risk: Observational and Mendelian Randomization Analyses https://pubmed.ncbi.nlm.nih.gov/35900194/

Physical Activity and Risk of Endometrial Adenocarcinoma in the Nurses' Health Study https://pubmed.ncbi.nlm.nih.gov/24213924/

Hysterectomy-Corrected Uterine Corpus Cancer Incidence Trends and Differences in Relative Survival Reveal Racial Disparities and Rising Rates of Nonendometrioid Cancers https://pubmed.ncbi.nlm.nih.gov/31116674/

Type I and II Endometrial Cancers: Have They Different Risk Factors? https://pubmed.ncbi.nlm.nih.gov/23733771/

Differential Trends in Rising Endometrial Cancer Incidence by Age, Race, and Ethnicity https://pubmed.ncbi.nlm.nih.gov/36625534/

Harvard Radcliffe Institute. Podcast Episode 208: Kindness—It’s Good for You! December 12, 2024. Interview with Immaculata De Vivo and Daniel Lumera, authors of “The Biology of Kindness: Six Daily Choices for Health, Well-Being, and Longevity.” Accessed May 13, 2026. https://www.radcliffe.harvard.edu/news-and-ideas/episode-208-kindness-it-s-good-for-you

Research Project—Cooperative Agreements (U01) https://grants.nih.gov/funding/activity-codes/u01

Center for Inherited Disease Research https://cidr.jhmi.edu/

Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs Ursula A. Matulonis and Marisa R. Nucci discuss the future of AI and pathology and how genetics and genomics play a role in the diagnosis of endometrial cancer.

Relevant disclosures can be found with the episode show notes on Medscape https://www.medscape.com/ca8/p04/podcast-endometrial-cancer-s3-ep5-2026a10006if. The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

Endometrial Carcinoma https://emedicine.medscape.com/article/254083-overview

WHO Classification of Tumours Online https://tumourclassification.iarc.who.int/welcome/

The Cancer Genome Atlas Program (TCGA) https://www.cancer.gov/ccg/research/genome-sequencing/tcga

TCGA Molecular Prognostic Groups of Endometrial Carcinoma: Current Knowledge and Future Perspectives https://pubmed.ncbi.nlm.nih.gov/36232987/

FIGO Staging of Endometrial Cancer: 2023 https://pubmed.ncbi.nlm.nih.gov/37337978/

The Desert Immune Phenotype in Endometrial Carcinoma: A Distinct Subgroup With Poor Prognosis and Targetable Mutations https://pubmed.ncbi.nlm.nih.gov/41967711/

Controversies in the Management of Serous Tubal Intra-Epithelial Carcinoma Lesions of the Fallopian Tube https://www.international-journal-of-gynecological-cancer.com/article/S1048-891X(25)00192-6/fulltext

Comparative Modeling of Recent and Projected Trends in the Incidence and Mortality of Uterine Cancer https://pubmed.ncbi.nlm.nih.gov/41643197/

Current Prognostic and Predictive Biomarkers for Endometrial Cancer in Clinical Practice: Recommendations/Proposal From the Italian Study Group https://pubmed.ncbi.nlm.nih.gov/35463299/

Application of Artificial Intelligence in Gynecologic Cancers: A Bibliometric Analysis https://pubmed.ncbi.nlm.nih.gov/41585300/

Uterine Leiomyosarcoma https://pubmed.ncbi.nlm.nih.gov/35173990/

Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs Ursula A. Matulonis and Stephanie Lheureux discuss the importance of investigator-initiated clinical trials in endometrial cancer, research on carcinosarcoma, and ctDNA.

Relevant disclosures can be found with the episode show notes on Medscape https://www.medscape.com/ca8/p04/podcast-endometrial-cancer-s3-ep4-2026a10006ie. The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

Endometrial Carcinoma https://emedicine.medscape.com/article/254083-overview

Advances in Antibody-Drug Conjugates for Endometrial Cancer https://pubmed.ncbi.nlm.nih.gov/40111079/

TCGA Molecular Prognostic Groups of Endometrial Carcinoma: Current Knowledge and Future Perspectives https://pubmed.ncbi.nlm.nih.gov/36232987/

Translational Randomized Phase II Trial of Cabozantinib in Combination With Nivolumab in Advanced, Recurrent, or Metastatic Endometrial Cancer https://pubmed.ncbi.nlm.nih.gov/35288469/

Elucidating Divergent Biology in Uterine Carcinosarcoma https://pubmed.ncbi.nlm.nih.gov/40850250/

The Immune Microenvironment in Endometrial Carcinoma: Mechanisms and Therapeutic Targeting https://pubmed.ncbi.nlm.nih.gov/40746533/

Epithelial-Mesenchymal Transition Orchestrates Tumor Microenvironment: Current Perceptions and Challenges https://pubmed.ncbi.nlm.nih.gov/40176117/

Comparative Modeling of Recent and Projected Trends in the Incidence and Mortality of Uterine Cancer https://pubmed.ncbi.nlm.nih.gov/41643197/

Genomic Landscape of ctDNA and Real-World Outcomes in Advanced Endometrial Cancer https://pubmed.ncbi.nlm.nih.gov/39417689/

Targeting CDK2 for Cancer Therapy https://pubmed.ncbi.nlm.nih.gov/40802510/

PYNNACLE Phase II Trial Assessing Rezatapopt (PC14586), a Selective p53 Reactivator, in Patients With Locally Advanced or Metastatic Solid Tumors Harboring a TP53 Y220C Mutation https://www.gynecologiconcology-online.net/article/S0090-8258%2825%2900347-6/abstract

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