In this episode, Sam Smith will discuss and help you understand the essential organic chemistry mechanisms and reactions you may encounter when taking the MCAT.

From nucleophilic substitution reactions like SN1 and SN2 to aldol condensation and oxidation and reduction of alcohols, Sam will cover the high-yield topics that are crucial for your test prep. He will also touch on key IR and NMR values that could appear on your exam.

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(00:00) Intro

(01:42) SN1 and SN2 nucleophilic substitution reactions, mechanisms, and key concepts

(03:18) Carbonyl substitution and addition reactions

(06:12) Introduction to aldol condensation reactions

(07:17) Overview of oxidation and reduction reactions

(10:09) Explanation of Fischer esterification and saponification

(12:51) Summary of elimination reactions (E1 and E2) and their distinguishing features.

(13:38) What numbers to know for IR and NMR

Understanding study design and research variables is crucial for mastering the MCAT and in medical research.

In this episode, host Sam Smith discusses the essentials of study design and research methods, from understanding independent and dependent variables to navigating the complexities of correlation, causation, and confounding variables. You’ll learn about the different types of studies, including experimental, observational, case-control, and cohort designs, and how they apply to MCAT questions. Plus, we’ll explore odds ratios, study validity, and the importance of specificity and sensitivity in diagnostic tests. This episode also covers common study limitations and biases, helping you sharpen your critical thinking skills for exam day.

Visit MedSchoolCoach.com for more help with the MCAT.

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(00:00) Intro

(01:22) Types of variables seen in studies

(03:10) Correlation and Pearson correlation coefficient

(05:38) Causation vs. correlation

(07:16) Confounding variables: Examples and impact

(08:55) Odds ratio and study applications

(11:00) Validities in experiments

(16:20) Specificity vs. sensitivity in diagnostic tests

(19:13) Types of studies: Experimental and observational

(31:32) Single blind vs. double blind studies

(32:58) Randomized controlled trials (RCTs)

(35:57) Research limitations and study bias

(45:39) MCAT Advice of the Day

In this episode, we're diving deep into the nuanced aspects of metabolism that are essential yet less prominently featured on the MCAT. We'll cover gluconeogenesis, the pentose phosphate pathway, and ketone body generation—topics that, while subtle, play a crucial role in your comprehensive understanding of biochemistry.

We'll explore how your body manages glucose levels, the functions of NADPH, how glycogen is synthesized and broken down, and the metabolic adaptations during periods of low glucose.

Visit MedSchoolCoach.com for more help with the MCAT.

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(00:00) Intro
(01:54) Pentose phosphate pathway overview
(02:42) Functions of NADPH in the body
(03:35) Difference between NADPH and NADH
(04:34) Key points to know about the pentose phosphate pathway
(07:01) Insulin and glucagon: hormonal regulation of blood glucose
(09:00) Effects of insulin & glucagon on the body
(10:48) Glycogen synthesis & breakdown
(15:51) Glycogen debranching enzyme and breakdown of branched chains
(18:49) Bypassing irreversible steps in glycolysis during gluconeogenesis
(21:19) Regulation of gluconeogenesis
(22:25) Ketogenic amino acids and their role in ketone body formation
(24:04) MCAT advice of the day: reading journal articles

In this episode, we’ll learn the intricate world of biomolecule structure, naming, and function. We'll explore the structural nuances between glucose and fructose and unravel the complexities of glycosidic linkages in sucrose. We'll also examine the vital roles of fatty acids, the composition of triglycerides and phospholipids, and their impact on cell membrane architecture and fluidity. Plus, we discuss cholesterol's bidirectional regulation of membrane stability and the contrasting roles of LDL and HDL in cardiovascular health.

We’ll dive into the essential structures and functions of steroids and nucleotides, as well as the fundamentals of DNA and RNA structure and the importance of ATP. We'll also look at the unique properties of sphingolipids, glycerophospholipids, and signaling molecules like eicosanoids.

So, tune in as we break down these critical biomolecules that form the foundation of life and are essential knowledge for the MCAT exam.

Visit MedSchoolCoach.com for more help with the MCAT.

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(00:00) Intro

(01:03) Overview of Biomolecule Structure and Importance

(02:37) Steroid Structure and Function

(06:36) Nucleotide Structure and Function

(12:02) DNA Structure and Bonding

(16:30) Carbohydrate Structure

(19:53) Disaccharides and Polysaccharides

(24:47) Fatty Acids and Phospholipids

(28:57) Cholesterol and Its Role in Membrane Fluidity

(31:27) Sphingolipids and Their Functions

(33:02) Eicosanoids: Signaling Molecules

(38:12) Heme Groups and Their Functions

(41:12) Molecule Entry into Cells

(44:12) MCAT Advice of the Day

In this episode, we explore enzyme kinetics and inhibition, key concepts for the MCAT Bio/Biochem section. We’ll cover how enzymes accelerate biological reactions by lowering activation energy and introduce two models for enzyme-substrate interaction: the lock-and-key model and the induced fit model.

You'll learn how to apply the Michaelis-Menten equation, focusing on factors like Km and Vmax to understand enzyme efficiency and substrate binding. We’ll also break down the different types of enzyme inhibition—competitive, non-competitive, and uncompetitive—and their effects on enzyme activity. Finally, we discuss the six major types of enzymes and their roles in biological processes, with examples like ligases, isomerases, and hydrolases.

Visit MedSchoolCoach.com for more help with the MCAT.

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(00:00) Introduction to enzyme kinetics and inhibition

(01:58) Definition of enzymes and their role

(03:50) Enzyme models: lock and key vs. induced fit

(06:28) Michaelis-Menten Equation

(10:53) Association and dissociation constants

(12:34) Kcat and catalytic efficiency

(14:43) Assumptions of Michaelis-Menten

(18:23) Lineweaver-Burk Plot: linearized Michaelis-Menten Equation

(21:09) Enzyme inhibition: reversible vs. irreversible

(22:14) Competitive inhibition: Km and Vmax

(24:46) Non-competitive inhibition: Effects on Km and Vmax

(27:20) Irreversible inhibition

(29:13) Allosteric inhibition

(31:26) Homotropic and feedback inhibition

(37:40) Common biological enzymes: dehydrogenase, synthetase, and kinase

(43:44) MCAT Advice of the Day

In this episode, we cover the foundational concepts of genetics, focusing on chromosomes, mitosis, meiosis, and inheritance patterns—important topics for the MCAT Bio/Biochem section. We’ll discuss how Gregor Mendel’s laws of segregation, independent assortment, and dominance influence inheritance and how Charles Darwin’s theory of natural selection relates to modern genetics.

The episode includes an overview of chromosome structure, the differences between X and Y chromosomes, and the effects of chromosomal mutations like deletions, duplications, and translocations. Mitosis and meiosis are also explained, with an emphasis on their roles in cell division and genetic diversity. Additionally, we explore genetic concepts such as codominance, incomplete dominance, genetic leakage, and how factors like penetrance and expressivity influence gene expression.

Visit MedSchoolCoach.com for more help with the MCAT.

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(00:00) Introduction to Genetics and Chromosomes

(01:41) Background on genetics: Key figures and their contributions (Mendel, Darwin)

(03:37) Mendel’s Laws: Segregation, independent assortment, and dominance

(05:50) Charles Darwin: Evolution and natural selection in genetics

(09:43) Chromosomes and DNA: Discovery and role in inheritance

(11:29) Chromosome Numbers and Structure: Ploidy, chromatids, and human chromosomes

(14:06) X and Y Chromosomes: Sex determination and sex-linked traits

(18:34) Chromosomal Mutations: Duplication, deletion, inversion, translocation

(22:00) Mitosis: Stages and the production of identical daughter cells

(28:16) Meiosis: Gamete formation and genetic diversity

(32:40) Centrosome, Centromere, and Centriole: Roles in cell division

(33:50) Genes and Phenotypes: Alleles, genotypes, and their effect on traits

(38:28) Dominant and Recessive Alleles: How traits are determined

(40:37) Genetic Leakage, Penetrance, and Expressivity: Gene flow, expression likelihood, and variability

(42:47) MCAT Advice of the Day

In this episode, Sam Smith covers the intricacies of metabolism, focusing on glycolysis, the Krebs cycle, and the electron transport chain.

First, the podcast explores the process of glycolysis, breaking down the key enzymes, intermediates, and regulation points. Next is the citric acid cycle, examining its regulation, energy production, and the roles of specific enzymes and intermediates. Lastly, we look at the electron transport chain and discuss how electrons are transferred through the five complexes, creating a proton gradient that drives ATP synthase to produce ATP.

Visit MedSchoolCoach.com for more help with the MCAT.

Jump into the conversation:

(00:00) Intro

(03:15) Ten steps of glycolysis: Intermediate names and enzymes

(08:01) Simplified glycolysis process: Breaking down key steps

(12:30) Glycolysis regulation: Allosteric regulation of enzymes

(21:13) Mnemonics for Krebs cycle intermediates

(25:52) Regulation of the Krebs cycle: ATP, calcium, and more

(30:26) Electron transport chain: Overview and key steps

(34:35) ATP synthase

(33:00) Reduction potentials in the electron transport chain

(37:31) Synopsis of metabolism

(40:34) MCAT Advice of the Day

Acids and bases are foundational topics in chemistry, crucial for understanding various biological and chemical systems you'll encounter in the MCAT.

In this episode, host Sam Smith discusses the selection and use of indicators in titrations to the pH at the equivalence point and the importance of buffers in maintaining physiological pH levels. You'll learn about the Henderson-Hasselbalch equation, the blood buffer system, and how to tackle common problems involving acids and bases. Plus, we'll break down strong and weak acids and the significance of their dissociation constants. This episode also shares tips on calculating pH, using ICE tables for weak acid problems, and converting between pH, pOH, and ion concentrations.

Visit MedSchoolCoach.com for more help with the MCAT.

Jump into the conversation:

(00:00) Intro
(02:16) Basic definitions of acids and bases
(11:33) Calculating pH
(24:55) Titrations
(35:26) Buffers
(41:16) Blood buffer system
(45:25) MCAT advice of the day