Louisville football is primed for a high-stakes Week One showdown against Ole Miss, the only ranked-vs-ranked game on opening weekend — and they’re six-and-a-half point underdogs. CBS Sports’ analysts unanimously picked Ole Miss to win, fueling Louisville’s fire under head coach Jeff Brohm, known as the “slay-the-giant whisperer” for his knack at shocking top opponents. Armed with elite talent, a dynamic running back duo, a dominant edge rusher, and a new Ohio State QB, the Cardinals are hungry to make it four straight upsets and send a bold statement right out of the gate.

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Ole Miss’s new head coach, Pete Golding, kicks off his first full season with a high-stakes Labor Day showdown against Louisville — but this game’s real drama lies in four breakout stars: Heisman finalist QB Trinidad Chambliss, Doak Walker Award winner RB Kewan Lacy, and Louisville’s electric duo of RB Isaac Brown and debut-starting QB Lincoln Kienholz. Chambliss and Lacy’s playoff magic last year set the tone, while Brown’s ACC dominance and Kienholz’s long-awaited starting role promise fireworks. This isn’t just about coaching changes — it’s about players poised to steal the spotlight and earn major awards.

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Louisville’s underdog dream is alive as they take on ninth-ranked Ole Miss in a high-stakes Week One showdown — and Coach Jeff Brohm, the self-proclaimed “giant killer,” is ready to make history again. After years out of the spotlight, the Cardinals are poised to prove they’re playoff contenders, with a roster built for big moments and a coach who’s already toppled top-tier teams like Ohio State, Michigan State, Notre Dame, and Clemson. A win here could turn Louisville from dark horse into national darling — and this game might just be the spark that lights up their season.

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