This weekend's CFB Week 10 clash between the Iowa State Cyclones and the Arizona State Sun Devils is far more than a mid-season college football contest; it's a volatile Big 12 Championship rematch. Though both programs, currently sitting at 5-3, are likely outside the College Football Playoff picture and the immediate Big 12 standings race, the historical bad blood and high stakes for bowl eligibility make this a massive game. Last year’s title bout, which saw the Sun Devils claim the trophy, ensures the atmosphere at Jack Trice Stadium will be electric, providing must-watch NCAA football content for fans and YouTube highlight creators. The central storyline is navigating significant injury news. Iowa State is fighting through deep secondary woes and running back rotation issues, while Arizona State’s offense is reeling from the loss of starting quarterback Sam Leavitt and the questionable status of top wide receiver Jordyn Tyson, forcing veteran Jeff Sims into the starting role. This defensive and offensive attrition changes the entire game day preview and prediction landscape. Look for a hard-fought, smashmouth football game characterized by strong defensive play. The key to victory will be who manages the debilitating injury crisis better. Despite falling short of preseason expectations, this Big 12 matchup is crucial for 2025 recruiting momentum and provides a critical test of character for both head coaches

Peloton
Let yourself run, lift, flex, and push forward. Explore the new Peloton Cross Training Tread+ today at https://www.onepeloton.com.

DoorDash
With DoorDash Streaks, you save every Saturday you order — stack it up all season and you could save up to $250. Order this Saturday. Keep the streak alive. Fuel your gameday — only with DoorDash. Terms apply. Promo period through 11/18.

Mazda
It’s the small details that make the big plays. And just like there’s more to every player, there’s more to a Mazda vehicle.
Mazda. Move and Be Moved.

Gametime
Today's episode is brought to you by Gametime. Download the Gametime app, create an account, and use code LOCKEDONCOLLEGE for $20 off your first purchase. Terms and conditions apply.

FanDuel
Today's episode is brought to you by FanDuel. Football season is around the corner, visit the FanDuel App today and start planning your futures bets now.

FANDUEL DISCLAIMER: 21+ in select states. First online real money wager only. Bonus issued as nonwithdrawable free bets that expires in 14 days. Restrictions apply. See terms at sportsbook.fanduel.com. Gambling Problem? Call 1-800-GAMBLER or visit FanDuel.com/RG (CO, IA, MD, MI, NJ, PA, IL, VA, WV), 1-800-NEXT-STEP or text NEXTSTEP to 53342 (AZ), 1-888-789-7777 or visit ccpg.org/chat (CT), 1-800-9-WITH-IT (IN), 1-800-522-4700 (WY, KS) or visit ksgamblinghelp.com (KS), 1-877-770-STOP (LA), 1-877-8-HOPENY or text HOPENY (467369) (NY), TN REDLINE 1-800-889-9789 (TN)

Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Could the Big 12 end up having three different schools in the expanded 12-team college football playoff? The BYU Cougars, Texas Tech Red Raiders and Houston Cougars all have a shot. What do we make of the Utah Utes being handed College Gameday this weekend ahead of their matchup with the Cincinnati Bearcats? Is that a big win for the Big 12?

https://www.youtube.com/channel/UCqNQsWmyf0LCFUKr01QZ2LQ

Locked On College Football Podcast

https://lockedonpodcasts.com/podcasts/locked-on-college-football/

Locked On College Conferences, HBCU, Basketball & More

🎧 https://linktr.ee/LockedOnCollege

Follow on Twitter: https://twitter.com/smclaughlinCFB

Follow the show on Twitter: https://twitter.com/LockedOn_CFB

Support Us By Supporting Our Sponsors!

Peloton

Let yourself run, lift, flex, and push forward. Explore the new Peloton Cross Training Tread+ today at https://www.onepeloton.com.

DoorDash

With DoorDash Streaks, you save every Saturday you order — stack it up all season and you could save up to $250. Order this Saturday. Keep the streak alive. Fuel your gameday — only with DoorDash. Terms apply. Promo period through 11/18.

Mazda

It’s the small details that make the big plays. And just like there’s more to every player, there’s more to a Mazda vehicle.

Mazda. Move and Be Moved.

Gametime

Today's episode is brought to you by Gametime. Download the Gametime app, create an account, and use code LOCKEDONCOLLEGE for $20 off your first purchase. Terms and conditions apply.

FanDuel

Today's episode is brought to you by FanDuel. Football season is around the corner, visit the FanDuel App today and start planning your futures bets now.

FANDUEL DISCLAIMER: 21+ in select states. First online real money wager only. Bonus issued as nonwithdrawable free bets that expires in 14 days. Restrictions apply. See terms at sportsbook.fanduel.com. Gambling Problem? Call 1-800-GAMBLER or visit FanDuel.com/RG (CO, IA, MD, MI, NJ, PA, IL, VA, WV), 1-800-NEXT-STEP or text NEXTSTEP to 53342 (AZ), 1-888-789-7777 or visit ccpg.org/chat (CT), 1-800-9-WITH-IT (IN), 1-800-522-4700 (WY, KS) or visit ksgamblinghelp.com (KS), 1-877-770-STOP (LA), 1-877-8-HOPENY or text HOPENY (467369) (NY), TN REDLINE 1-800-889-9789 (TN)

#CollegeFootball

Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

The Iowa State Cyclones' 5-3 start is a testament to resilience, but it also reflects the heavy toll taken by defensive injuries this season. Under Defensive Coordinator Jon Heacock, the unit is typically the rock of Matt Campbell’s program, yet its depth has been systematically shredded by long-term losses. This attrition has been particularly acute in the defensive backfield, which recently saw cornerbacks Jeremiah Cooper and Jontez Williams, both key playmakers, ruled out for the year with severe knee injuries.

The news that yet another defensive player, corner Khijohnn Cummings-Coleman, is now out for the remainder of the season, only compounds the crisis. This third major loss in the secondary forces younger, less experienced players like Tre Bell and Quentin Taylor Jr. into full-time roles, leaving defensive coaches scrambling to adjust their complex schemes with limited personnel. While the defense has battled valiantly—often still finding ways to limit opponents—the cumulative fatigue and reduction in talent depth have led to critical breakdowns in key moments, contributing directly to the team's three losses.

The question facing the team now is simple but daunting: What is the contingency plan? With the most vital position groups thinned out, Campbell must rely heavily on coaching adjustments and rapid development from backups. The Cyclones are facing the reality that their path to a strong finish will not be paved by star power, but by the grit of their remaining rotation players.

Peloton
Let yourself run, lift, flex, and push forward. Explore the new Peloton Cross Training Tread+ today at https://www.onepeloton.com.

DoorDash
With DoorDash Streaks, you save every Saturday you order — stack it up all season and you could save up to $250. Order this Saturday. Keep the streak alive. Fuel your gameday — only with DoorDash. Terms apply. Promo period through 11/18.

Mazda
It’s the small details that make the big plays. And just like there’s more to every player, there’s more to a Mazda vehicle.
Mazda. Move and Be Moved.

Gametime
Today's episode is brought to you by Gametime. Download the Gametime app, create an account, and use code LOCKEDONCOLLEGE for $20 off your first purchase. Terms and conditions apply.

FanDuel
Today's episode is brought to you by FanDuel. Football season is around the corner, visit the FanDuel App today and start planning your futures bets now.

FANDUEL DISCLAIMER: 21+ in select states. First online real money wager only. Bonus issued as nonwithdrawable free bets that expires in 14 days. Restrictions apply. See terms at sportsbook.fanduel.com. Gambling Problem? Call 1-800-GAMBLER or visit FanDuel.com/RG (CO, IA, MD, MI, NJ, PA, IL, VA, WV), 1-800-NEXT-STEP or text NEXTSTEP to 53342 (AZ), 1-888-789-7777 or visit ccpg.org/chat (CT), 1-800-9-WITH-IT (IN), 1-800-522-4700 (WY, KS) or visit ksgamblinghelp.com (KS), 1-877-770-STOP (LA), 1-877-8-HOPENY or text HOPENY (467369) (NY), TN REDLINE 1-800-889-9789 (TN)