This week's episode is in honour of Frank Beier, who recently passed away on July 18, 2025. Frank leaves behind a remarkable legacy through the impact he made in the field of osteoarthritis. In this previous episode (2021), he discussed the recent advances in osteoarthritis understanding with a particular emphasis on novel targets and epigenetics.

Despite the large prevalence of osteoarthritis, there is no clinically approved drug which provides a cure. Currently, drugs focus on relieving symptoms such as pain. Experiments done in the laboratory have provided insight on osteoarthritis onset and progression and will likely guide therapeutic development.

We know that osteoarthritis is a disease of the whole organ meaning that any of the tissues involved in the synovial joint can be affected. The interplay between the various cell types involved is complex and understanding the interactions between cartilage, bone and synovium may be critical to therapeutic development.

Skeletal development likely plays a very important role in predisposition to disease. Through the identification of serious pathologies such as various forms of dwarfism (what in medical terms are called chondrodysplasias) the role of transcription factors and epigenetics is increasing our understanding of disease genesis.The study of the epigenetics of OA - the mechanism by which the human genome alters it’s gene expression (without changing the primary DNA sequence) has provided valuable information on novel risk factors for the disease and are potential therapeutic targets for OA.

RESOURCES

Journal articles

• Nuclear receptors as potential drug targets in osteoarthritis
• Interplay between genetics and epigenetics in osteoarthritis
• Recent developments in emerging therapeutic targets of osteoarthritis

CONNECT WITH US

• Twitter: @ProfDavidHunter @jointactionorg
• Email: hello@jointaction.info
• Website: www.jointaction.info/podcast

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On this week's episode of Joint Action discover how ultra-processed foods may be silently contributing to osteoarthritis. Dr Gabby Joseph joins us to discuss her research research linking poor diet quality to greater knee pain, poorer physical function and thinner knee cartilage.

Dr Gabby Joseph is a scientist and statistician with over 20 years of experience leading research funded by the US government at the University of California San Francisco, Her work focuses on musculoskeletal imaging, predictive modelling, and clinical study design, with a focus on applying advanced statistical and machine learning methods to improve patient outcomes

She is the co-Director of The University of California's Clinical & Translational Musculoskeletal Imaging group and passionate about making sense of complex data so that it can be used to improve real-world care.

RESOURCES

• Ultra-processed food consumption is associated with knee osteoarthritis: Data from the Osteoarthritis Initiative

CONNECT WITH US

• Twitter: @ProfDavidHunter @jointactionorg
• Instagram: @osteoarthritisresearchgroup
• Email: osteoarthritis.research@sydney.edu.au
• Website: www.jointaction.info/podcast

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Dribbling into discovery - on this episode of Joint Action, we are joined by Dr John Drazan to learn more about how he is using basketball to inspire the next generation of scientists. Dr John Drazan is an Assistant Professor of biomedical engineering at Fairfield University where he studies the relationship between muscle structure and function to understand how muscles remodel in response to aging, injury, or training.

He is an award-winning STEM educator and former collegiate basketball player who runs STEM focused clinics to encourage student interest in maths, science, technology and engineering. His innovative programs have reached over 25,000 students across the USA.

CONNECT WITH US

• Twitter: @ProfDavidHunter @jointactionorg
• Instagram: @osteoarthritisresearchgroup
• Email: hello@jointaction.info
• Website: www.jointaction.info/podcast

If you enjoyed this episode, don't forget to subscribe to learn more about osteoarthritis from the world's leading experts! And please let us know what you thought by leaving us a review!

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Did you know your beliefs about osteoarthritis could be making your symptoms worse? In this re-aired episode from Season 5, Episode 1 of Joint Action, physiotherapist and health communication expert Dr Ben Darlow joins us to explore how common misconceptions - like “wear and tear” or “bone on bone” - can limit your activity and shape your treatment choices. We discuss the power of language, the importance of hope, and how better understanding can help you take control of your health.

Whether you're living with osteoarthritis, supporting someone who is, or working in healthcare, this conversation is a must-listen.

RESOURCES

• Living with osteoarthritis is a balancing act: an exploration of patients' beliefs about knee pain
• The osteoarthritis knowledge scale

CONNECT WITH US

• Twitter: @ProfDavidHunter @jointactionorg
• Email: hello@jointaction.info
• Website: www.jointaction.info/podcast

If you enjoyed this episode, don't forget to subscribe to learn more about osteoarthritis from the world's leading experts! And please let us know what you thought by leaving us a review!

Hosted on Acast. See acast.com/privacy for more information.

Methotrexate is a well-established drug used in oncology, but could it also play a role in managing osteoarthritis? In this episode of Joint Action, Professor David Hunter is joined by Dr Anna Døssing and Professor Robin Christensen to explore the potential of methotrexate as a treatment for osteoarthritis pain.

They discuss:

• What methotrexate is and how it works
• Insights from a recent meta-analysis on its effectiveness and safety
• Why individual studies show mixed results
• Whether it might help people with hand or knee OA - especially those with signs of inflammation
• How dosing and side effects factor into clinical decision-making

Tune in for an honest, data-driven conversation about repurposing an old drug for a new purpose - and what it could mean for people living with osteoarthritis.

RESOURCES

• Editorial: Methotrexate for osteoarthritis—Ready for clinical use and in whom?: https://www.oarsijournal.com/article/S1063-4584(25)00973-2/abstract?

CONNECT WITH US

• Twitter: @ProfDavidHunter @jointactionorg
• Instagram: @osteoarthritisresearchgroup
• Email: osteoarthritis.research@sydney.edu.au
• Website: https://www.jointaction.info/podcast

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Metformin is one of the world’s most prescribed drugs for type 2 diabetes - but could it also help with knee osteoarthritis? In this episode of Joint Action, Prof. David Hunter is joined by Prof. Flavia Cicuttini to unpack the results of a groundbreaking clinical trial that tested metformin as a new treatment for knee pain in people with knee osteoarthritis. Tune in to hear what the study found, how the drug works, who might benefit, and what this could mean for delaying joint replacement.

RESOURCES

• Article: Metformin for Knee Osteoarthritis in Patients With Overweight or Obesity: https://jamanetwork.com/journals/jama/article-abstract/2833338

CONNECT WITH US

• Twitter: @ProfDavidHunter @jointactionorg
• Instagram: @osteoarthritisresearchgroup
• Email: osteoarthritis.research@sydney.edu.au
• Website: https://www.jointaction.info/podcast

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In this episode of Joint Action, Professor David Hunter is joined by Dr. Stephanie Mathies and Dr. Giovanni Ferreira to unpack the cost-effectiveness of osteoarthritis treatments. They discuss the results of their recent systematic review, which analysed over 100 studies to identify which guideline-recommended treatments provide the best value for money.

From exercise and medications to injections and surgery, they explore which interventions are truly cost-effective - and which may not be worth the spend. Learn why “simple things” like exercise and education still offer the most value, and what this means for patients, clinicians, and healthcare policy.

RESOURCES

Article:

• The cost-effectiveness of guideline-recommended treatments for osteoarthritis: A systematic review: https://www.oarsijournal.com/article/S1063-4584(25)00972-0/abstract

CONNECT WITH US

• Twitter: @ProfDavidHunter @jointactionorg
• Instagram: @osteoarthritisresearchgroup
• Email: osteoarthritis.research@sydney.edu.au
• Website: https://www.jointaction.info/podcast

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In this week's episode of Joint Action, Professor David Hunter is joined by Dr Sarah Kobayashi, a lecturer in anatomy and osteoarthritis researcher, to talk about the power of walking - especially for people with osteoarthritis.

Sarah shares her insights into the many health benefits of walking, why it’s so important for joint health, and how to overcome common barriers to getting started. She also introduces the CASCADE-OA study (Community bAsed phySical aCtivity AnD sElf-management for OsteoArthritis), a 12-month clinical trial exploring the effectiveness of a self-directed walking program, Walk With Ease Australia, in improving physical activity levels and managing symptoms for those with hip or knee osteoarthritis.

Whether you're new to walking or looking to establish a sustainable routine, this episode offers practical advice and motivation to help you take that first step.

RESOURCES

Learn more about the CASCADE-OA study and check your eligibility:

• CASCADE-OA Study Overview: www.osteoarthritisresearch.com.au/cascadeoa-study-overview

Ask your local arthritis organisation about Walk With Ease or the CASCADE-OA study:

• Arthritis Australia – www.arthritisaustralia.com.au/state-offices/

Additional resources:

• Versus Arthritis Walking Guide (UK): www.versusarthritis.org/about-arthritis/exercising-with-arthritis/exercises/walking
• Heart Foundation Walking Groups (Australia) – walking.heartfoundation.org.au
• Parkrun Australia: www.parkrun.com.au

CONNECT WITH US

• Twitter: @ProfDavidHunter @jointactionorg
• Instagram: @osteoarthritisresearchgroup
• Email: osteoarthritis.research@sydney.edu.au
• Website: www.jointaction.info/podcast

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