『Johns Hopkins Malaria Minute』のカバーアート

Johns Hopkins Malaria Minute

Johns Hopkins Malaria Minute

著者: Johns Hopkins Bloomberg School of Public Health
無料で聴く

このコンテンツについて

Impactful malaria science, and the trailblazers leading the fight. A podcast from the Johns Hopkins Malaria Research Institute. 科学
エピソード
  • The Goldilocks Dose: Modulating Mosquito Diet to Control Malaria
    2025/09/09

    Feeding mosquitoes L-DOPA can either strengthen their defences against malaria or shorten their lifespan — showing that in vector control, the dose makes the difference

    Transcript

    As with all medicine, the dose determines whether something helps or harms.

    Researchers recently looked at a substance commonly found in mosquito habitats that might form part of their diet. It’s called L-3-4-dihydroxyphenylalanine, or L-DOPA. Mosquitoes use it as a source of melanin.

    At low doses – up to a concentration of 2% – L-DOPA was toxic to mosquitoes and reduced the number of malaria parasites they carry in a dose-dependent manner. At higher doses, toxicity was stronger and the mosquitoes’ rates of survival decreased, demonstrating what’s known as a biphasic dose response.

    These findings offer two potential strategies for L-DOPA in malaria control. Low doses fed to mosquitoes in water could improve their defences against the parasite, thereby reducing onward transmission to humans. Higher doses could be used to kill mosquitoes or reduce their life span, particularly if used in a sugar bait.

    These strategies align with the need for cost-effective, sustainable and eco-friendly vector control methods. For L-DOPA, it all comes down to the dose.

    Source

    Dietary L-3,4-dihydroxyphenylalanine (L-DOPA) augments cuticular melanization in Anopheles mosquitos reducing their lifespan and malaria burden

    About The Podcast

    The Johns Hopkins Malaria Minute podcast is produced by the Johns Hopkins Malaria Research Institute to highlight impactful malaria research and to share it with the global community.

    続きを読む 一部表示
    1 分
  • SPECIAL: Hackathons for Malaria Genetic Epidemiology (with Bryan Greenhouse)
    2025/08/29

    How do you turn vast amounts of genetic data into actionable insight – efficiently and accurately? Professor Bryan Greenhouse of UCSF discusses a series of “hackathons” at the Johns Hopkins Malaria Research Institute (JHMRI) that bring together scientists from around the world to tackle one of the biggest challenges in malaria research: analyzing parasite genetics. By developing open-source tools, workflows, and training resources, these collaborations are making cutting-edge analysis more accessible to labs and public health programs everywhere.

    続きを読む 一部表示
    11 分
  • EXTENDED: From River Blindness to Malaria Control – The Ivermectin Story (with Carlos Chaccour and Joseph Mwangangi)
    2025/08/19

    In Kwale, Kenya, where bed nets alone can’t stop malaria, researchers are testing ivermectin – a drug long used to treat parasitic infections – as a new way to kill mosquitoes. Trials show a 26% drop in malaria cases and added benefits against other mosquito-borne diseases, suggesting ivermectin could be a scalable, community-driven tool in the fight against insecticide resistance.

    With Carlos Chaccour (researcher at the Navarra Center for International Development) and Joseph Mwangangi (scientist at KEMRI)

    About The Podcast

    The Johns Hopkins Malaria Minute is produced by the Johns Hopkins Malaria Research Institute to highlight impactful malaria research and to share it with the global community.

    続きを読む 一部表示
    12 分
まだレビューはありません