In this episode of The Cancering Show, host Dr. Jennifer Young Pierce talks with Dr. Rebecca Perkins, a nationally recognized expert in cervical cancer prevention, about the latest updates in HPV testing and cervical cancer screening. They emphasize that HPV (human papillomavirus) is linked to virtually all cervical cancers (and several other cancers in men and women), and that testing for high-risk HPV is better at catching problems early compared with the traditional Pap test. The episode highlights new self-collection kits, in which patients can collect their own sample, usually at a doctor’s office, to make screening easier without a pelvic exam. However, if the test result is positive, the patient will need to follow up with a doctor for further tests. Home testing kits are also being introduced, but they’re not widely available yet. The main takeaway is that knowing your HPV status is crucial for preventing cervical cancer, and self-collection options will make screening more accessible for many people in the future. Listeners are encouraged to talk to their doctor about the best screening option for them and to always follow up after a positive test. Resources such as the American Cancer Society’s “Screening Tests for Cervical Cancer” and cervicalrisk.com are recommended for more information.

3 Key Takeaways


1. HPV testing is more effective than the Pap test alone.
The conversation emphasizes that HPV causes the vast majority of cervical cancers (99.7%), making HPV testing a critical component of early detection. Dr. Perkins explains that HPV testing can detect about 90% of pre-cancers and cancers, compared to roughly 70% with Pap tests. Because of its higher sensitivity, HPV testing can be done less frequently while still providing strong protection.


2. Self-collection for HPV testing expands access to screening.
Self-collection kits for HPV testing, which allow patients to collect their own samples in a clinic setting without a pelvic exam, are becoming more available.This approach encourages cervical cancer screening for individuals who may avoid or delay pelvic exams and helps integrate screening into primary care, family medicine, and even mobile clinics. While at-home kits are still not widely available, in-clinic self-collection is currently a promising step toward improving screening rates.


3. Follow-up after a positive HPV test is essential.
If a patient tests positive for high-risk HPV, especially types 16 or 18, it is important to follow up with additional testing or procedures, such as colposcopy, to check for pre-cancerous changes.The episode stresses that no one who tests positive for high-risk HPV should wait longer than one year for further evaluation, underlining the importance of timely follow-up to prevent cervical cancer.


Show Overview


02:17 Meet Rebecca Perkins, MD, MSc

03:11 HPV test vs. Pap test

04:55 Know your status

05:19 What to know if your HPV test is positive

08:39 HPV self-collection

10:48 Who should see a doctor for an exam?

14:00 Types of self-collection

18:50 HPV vaccine has reduced cervical cancer rates

20:28 Importance of follow-up after positive test results

21:15 When will home self-collection be available?

24:12 Where to find out more