A breast cancer diagnosis can flip your world in a single sentence—so we set out to restore clarity, calm, and control. Dr. Jason Edwards sits down with breast surgeon Dr. Nanette Wendel and medical oncologist Dr. Meera Rana to map a modern pathway through complex choices, from the first tumor board conversation to long-term survivorship. Together we show how to match treatment to tumor biology while protecting quality of life.

We start inside a multidisciplinary tumor board where surgeons, medical oncologists, radiation oncologists, radiologists, and pathologists collaborate on one coherent plan. You’ll hear why lumpectomy plus radiation can achieve survival equal to mastectomy in early-stage disease, how sentinel lymph node biopsy slashes lymphedema risk, and when MRI tips the balance between conservation and mastectomy. We unpack Oncotype and other genomic tests that separate patients who need chemotherapy from those who don’t, and we dig into the reasoning behind giving chemotherapy before surgery for HER2-positive and triple negative cancers.

Dr. Rana explains the evolving toolkit: endocrine therapy for hormone receptor–positive disease, PARP inhibitors for BRCA mutation carriers, CDK4/6 inhibitors for high-risk and metastatic settings, and immunotherapy’s growing role in triple negative breast cancer. Dr. Wendel brings the human side forward—how cosmetic outcomes and immediate reconstruction buffer the emotional hit of surgery, and why education often shifts patients away from default “double mastectomy” thinking toward evidence-based, confidence-preserving choices. We close with practical advice for the toughest first two weeks after diagnosis: record visits, bring another set of ears, ask for repetition, and lean on a plan that balances cure with the life you want to return to.

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