This week on Fat Science, Mark Wright, Andrea Taylor, and Dr. Emily Cooper dig deep into the science and history behind why diets don’t work for lasting weight management. From early fad diets, through to modern metabolic research, the episode explains why calorie restriction often backfires—and why fueling the body is key to long-term health.

Dr. Cooper unpacks the latest evidence about metabolic adaptation, the hormonal drivers of weight regain, and the persistent harms caused by repeated dieting. Listeners will leave with a renewed understanding of metabolism’s complexity, the importance of medical advocacy, and the critical need to challenge diet culture and weight bias.

Key Takeaways

• Short-term weight loss from dieting is common, but centuries of evidence show most weight is regained—sometimes with additional harm.
• Metabolic adaptation and hormonal changes (like drops in leptin and rises in ghrelin) make weight regain almost inevitable for most people after calorie restriction.
• Repeated dieting (weight cycling) increases the risk of cardiovascular disease and visceral fat, not just regaining lost weight.
• The biggest breakthroughs in metabolism came in the 20th century, but weight bias and diet industry profits keep the focus on ineffective short-term strategies.
• True long-term progress rests on regular fueling, metabolic evaluation, and avoiding the trap of repeated restrictive diets.

Expert Insights & Practical Advice

• Dr. Cooper highlights landmark studies (Minnesota Starvation Experiment, Dutch famine, the "Biggest Loser" follow-up) illustrating how diets slow metabolism and can even cause lasting damage.
• The science behind metabolic hormones—leptin, ghrelin, adiponectin, GLP-1—shows why the body fights back against weight loss and why medications must be paired with metabolic support, not additional restriction.
• Reflections on weight bias in medicine, the need for informed consent around diets, and how current research is still catching up to clinical reality.

Personal Stories & Culture Critique

• Andrea shares how social circles demonstrate the futility of diets and the cycle of weight loss and regain.
• Mark recounts professional experiences highlighting systemic bias and cultural attitudes toward weight and health, advocating for preventive medicine as the path forward.
• The hosts challenge listeners to rethink their relationship with food, prioritize health, and push back against societal shame and stigma.

Resources from the Episode

Fat Science is committed to debunking the myths about metabolism, diabetes, and fat. We empower listeners with evidence-based information, challenging the culture of blame and restriction. This podcast is for informational purposes and not medical advice.

• Explore our website to join our live audience for the milestone 100th episode recording on Thursday, September 4th at 9 a.m. PST—ask Dr. Cooper a question and celebrate with us!
• Send questions, show ideas, or feedback: questions@fatsciencepodcast.com or dr.c@fatsciencepodcast.com.
• Connect with Dr. Emily Cooper on [LinkedIn]
• Connect with Mark Wright on [LinkedIn]
• Connect with Andrea Taylor on [Instagram]

Fat Science: No diet, no agenda—just science that makes you feel better.

The 100th episode of Fat Science brings together Dr. Emily Cooper, Andrea Taylor, and Mark Wright for a live mailbag celebration with listeners worldwide. Hear how the show began, reflect on lessons learned, and get answers to the questions people wish their doctors would address—especially about metabolism, obesity, diabetes, GLP-1 medications, and more.

Dr. Cooper shares the big-picture science behind “why we get fat,” the true drivers of metabolic dysfunction, and the evolution of her pioneering clinical practice. Andrea and Mark reveal the patient’s perspective—an honest look at what happens when the latest science meets real lives. Plus, practitioners and patients weigh in on the shifting cultural tide: it’s not a diet problem, it’s a metabolic problem.

Key Takeaways:

• GLP-1 medications do not appear to harm future fertility or cause birth defect risks; improved metabolism may even help down the road.
• Leptin resistance/suppression: what labs really mean, why mechanical eating matters, and how ghrelin and other signals clarify the picture.
• “Diet Drug” stigma is outdated; GLP-1 medications target dysfunction, not willpower.
• Compounded GLP-1 solutions can be risky. Dr. Cooper explains supply chain, testing, and safer cost-saving alternatives like Lilly Direct, NovoCare, and Canadian Kwik pens.
• Autoimmune diseases (like celiac) may interfere with signals, but GLP-1s—especially bioidentical ones—are still options with careful monitoring.
• “Selfish Brain” explained: labs to request, what cerebral insulin suppression looks like, and why fueling and sleep are core solutions.
• Hashimoto’s: often distinct from metabolic dysfunction; both need tailored management and mechanical fueling.
• Heavy lifting & nutrition: protein needs often overstated—1.0–1.3g/kg ideal; pre-bed protein useful; DEXA scans help track muscle mass.
• Menopause & metabolism: estrogen/leptin loss, why patch plus micronized progesterone is often safest, and how each choice impacts metabolic health.
• Navigating insurance complexities, tariffs, and lifetime maxes—when and how to explore creative access.
• Metabolic changes tied to cycles, pregnancy, birth control: which progestins are weight-neutral, what to ask, and which labs to run if hitting plateaus.
• GLP-1s often improve blood pressure; dizziness may mean time to reduce meds, not the GLP-1.

Personal Stories & Practical Advice:Andrea and Mark share a decade-plus of metabolic journeys—their dramatic health wins and the ongoing battle for self-compassion and body image. Listeners celebrate victories: reversing fatty liver, thriving after cancer, and breaking free from diet cycles.

“No diets. No agendas. Just science that makes you feel better.” The audience and hosts repeat this Fat Science tagline to mark the milestone.

Resources:Fat Science explains where fat really comes from and why it won’t just go away. We’re committed to empowering people with accurate information about metabolism and busting the myth that fat is failure. This podcast is informational only and not medical advice.

Check out our new website to ask a mailbag question. Contact us at questions@fatsciencepodcast.com or dr.c@fatsciencepodcast.com.

Connect with Dr. Cooper on LinkedInConnect with Mark Wright on LinkedInConnect with Andrea Taylor on Instagram

This week on Fat Science, Dr. Emily Cooper, Andrea Taylor, and Mark Wright explore the dangers of under-fueling and challenge dieting myths with guest Gina Davito. This episode dives into Gina’s journey from extreme restriction and over-exercising to finally achieving metabolic balance and freedom from food obsession.

Dr. Cooper sheds light on the science behind metabolic adaptation, appetite regulation, and why fueling your body—rather than restricting—is essential for long-term health. Listeners will come away with a new perspective on weight management, the power of metabolic healing, and a celebration of food as a source of nourishment and joy.

Key Takeaways:

• Chronic dieting and excessive exercise can trigger severe metabolic adaptation and worsen weight gain, creating a cycle that is hard to break without proper medical support.
• Abnormal hunger and weight gain are symptoms of underlying metabolic dysfunction, not lack of willpower—often exacerbated by early and repeated dieting.
• True progress involves nourishing the body and trusting medical guidance, sometimes including tailored medications to reset metabolic balance.
• Mental freedom from food-related anxiety arrives with metabolic healing—allowing for joy in eating and exercise for health rather than punishment.
• Early interventions for kids showing unusual hunger or weight patterns should focus on metabolic evaluation, not restriction.

Personal Stories & Practical Advice:

• Gina describes her transformation from compulsive restriction to vibrant health and athleticism—no longer trapped by thoughts of food or weight.
• Andrea and Mark share their relief at experiencing food freedom and highlight the importance of enjoying both food and movement.

Resources from the episode:

Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.

Check out our new website where you can ask a mailbag question and sign up to be in the audience for our 100th episode we’re recording on Thursday, September 4th at 9 a.m.PST. Be part of the live audience and ask Dr. Cooper a question. We’d love to celebrate this milestone with you!

If you have a question for Dr. Cooper, a show idea, feedback, or just want to connect, email us at questions@fatsciencepodcast.com or dr.c@fatsciencepodcast.com.

• Connect with Dr. Emily Cooper on LinkedIn.
• Connect with Mark Wright on LinkedIn.
• Connect with Andrea Taylor on Instagram.