This episode is for educational purposes only. It is intended for mature audiences and explores scientific, historical, and cultural perspectives on psychoactive substances. Nothing in this content should be interpreted as medical advice or encouragement for illegal activity. Viewers are responsible for knowing and following their local laws. If you or someone you know is struggling with substance use or mental health, please seek support from a qualified healthcare provider.

A system hidden in plain sight. A molecule named after bliss. A plant that revealed it all.

Welcome to Episode 4 of thegreengage a podcast exploring the secret symphony of nature, mind, and science.

In this episode, we trace the astonishing story of the endocannabinoid system a vast, overlooked regulatory network inside the human body, first discovered because of cannabis.

From underground labs in 1960s Israel to breakthrough receptor mapping in the U.S., we follow how the study of THC led to the discovery of a system built not for intoxication, but for balance.

In this episode, we cover:• The discovery of THC and the mystery of how it worked• The emergence of CB1 and CB2 receptors in the brain and immune system• The brain’s own cannabis-like molecules: anandamide and 2-AG• How the ECS maintains internal balance: from stress to sleep to inflammation• Why cannabis acts not as an invader, but as a mirror of our internal intelligence• The clinical relevance of ECS dysregulation and its role in resilience

This is not just a story about a plant. It’s a story about how a plant helped science rediscover the body’s own language of equilibrium.

Green Gage’s is a 44-part journey into the chemistry of being — blending neuroscience, story, and psychoactive insight.

🔎 Keywords: endocannabinoid system, THC receptors, anandamide, what is ECS, cannabis and homeostasis, neuroscience podcast, psychoactive systems, CB1 CB2 explained, bliss molecule, resilience biology, Green Gage’s

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Welcome to Green Gage’s. Let’s begin.