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In this episode, we delve into the ongoing research and new findings related to Chronic Fatigue Syndrome (CFS). The discussion covers the development of standardized diagnostic criteria known as the Hingston Criteria, as well as the discovery of biological abnormalities in CFS patients. Key areas of focus include the autonomic nervous system, heart rate variability, and muscle strength. The episode also touches on the concept of 'effort preference' and the complex interplay between sympathetic and parasympathetic nervous system activity in chronic conditions like CFS and fibromyalgia. Additionally, the episode previews upcoming discussions on findings from functional MRIs of the brain in CFS patients.

00:00 Introduction and Importance of Defining the Disease
00:15 The Hingston Criteria: A New Standard for Clinical Trials
00:59 Biological Evidence and Clinical Trials
02:13 Autonomic Dysfunction in Chronic Fatigue Syndrome
04:14 Sympathetic and Parasympathetic Systems Explained
08:24 Chronic Stress and Its Impact on Health
10:21 Comparing Functional Somatic Syndromes and Stress-Related Syndromes
20:59 Muscle Strength and Cognitive Effort in CFS
22:28 Understanding EMG and Its Diagnostic Value
26:57 Effort Preference and Its Clinical Implications
28:42 Conclusion and Next Week's Preview

Joy Lenz

Fibromyalgia 101. A list of fibromyalgia podcast episodes that are great if you are new and don't know where to start.

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When I started this podcast—and the book that came before it—I had my patients in mind. Office visits are short, but understanding complex, often misunderstood conditions like fibromyalgia takes time. That’s why I created this space: to offer education, validation, and hope. If you’ve been told fibromyalgia “isn’t real” or that it’s “all in your head,” know this—I see you. I believe you. You’re not alone. This podcast aims to affirm your experience and explain the science behind it. Whether you live with fibromyalgia, care for someone who does, or are a healthcare professional looking to better support patients, you’ll find trusted, evidence-based insights here, drawn from my 28+ years as an MD.

Please remember to talk with your doctor about your symptoms and care. This content doesn’t replace personal medical advice.*