EP42 - Build Your Personal Gut-Brain Protocol (Without the Spreadsheet)
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We've covered food, the vagus nerve, sleep, supplements, gut tests, and exercise. In this capstone, Dave pulls it together into one honest, simple plan: four everyday levers (food, sleep, stress, movement), a five-step way to pick your weakest one and start small, and where supplements, tests, and your doctor fit. The four levers are a teaching framework, and every study is labeled for what it does and doesn't prove.
What you'll learn:
- What a major twenty nineteen review says about how your gut and brain communicate
- The fine print on one study for each lever
- A five-step process: weakest lever, one lever, tiny move, give it a month, then layer
- Where supplements, at-home tests, and medical care fit
Research referenced:
- Cryan JF, O'Riordan KJ, Cowan CSM, et al. The Microbiota-Gut-Brain Axis. Physiological Reviews, 2019.
- Lane MM, Gamage E, Travica N, et al. Ultra-Processed Food Consumption and Mental Health: A Systematic Review and Meta-Analysis of Observational Studies. Nutrients, 2022.
- Smith RP, Easson C, Lyle SM, et al. Gut microbiome diversity is associated with sleep physiology in humans. PLOS ONE, 2019.
- Magnon V, Dutheil F, Vallet GT. Benefits from one session of deep and slow breathing on vagal tone and anxiety in young and older adults. Scientific Reports, 2021.
- Allen JM, Mailing LJ, Niemiro GM, et al. Exercise Alters Gut Microbiota Composition and Function in Lean and Obese Humans. Medicine & Science in Sports & Exercise, 2018.
- Mosquera FEC, Lizcano Martinez S, Liscano Y. Effectiveness of Psychobiotics in the Treatment of Psychiatric and Cognitive Disorders: A Systematic Review of Randomized Clinical Trials. Nutrients, 2024.
- Servetas SL, Gierz KS, Hoffmann D, Ravel J, Jackson SA. Evaluating the analytical performance of direct-to-consumer gut microbiome testing services. Communications Biology, 2025.
This episode is educational and not a substitute for professional medical advice.
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