Romans 8:7 (ESV) states: "For the mind that is set on the flesh is hostile to God, for it does not submit to God's law; indeed, it cannot."
This verse is a crucial part of Paul's discussion in Romans 8 about the contrast between living "according to the flesh" and living "according to the Spirit."
Romans 8:7 describes the fundamental problem with the "mind that is set on the flesh" (often translated as "carnal mind" or "sinful nature"). This mindset, which represents humanity's natural, unregenerate state without the Holy Spirit, is hostile to God. It's not just indifferent or disobedient; it's actively opposed to Him. The reason for this hostility is explained: this mind does not submit to God's law, and in fact, it cannot. This highlights humanity's inability, apart from God's grace and the work of the Spirit, to truly obey or please God. It underscores the spiritual deadness and antagonism towards God inherent in a life dominated by sinful human nature.