“This conversation makes the case for a shift: from sustainability as a materials-and-energy conversation, to neurosustainability — designing environments that protect sleep, reduce stress load, support movement, and build cognitive resilience across the lifespan.” Jackie De Burca

Host: Mohamed Hesham Khalil – Creator of the Neurosustainability theory, architect and neuroscience researcher, and a PhD candidate at the University of Cambridge.

Guest: Professor Agustín Ibáñez — Director of Global Research Networks at the Global Brain Health Institute (Trinity College Dublin) and Scientific Director of the Latin American Brain Health Institute

Guest: Burcin Ikiz — Neuroscientist and brain health advocate working at the intersection of climate, equity, and brain outcomes

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Brain health isn’t only personal. It’s environmental. And the places we live, move, and work in can either build resilience — or quietly chip away at it.

“The built environment… is the space where we most of the time live, move, think and also thrive or become sick.” — Professor Agustín Ibáñez

In the third part of this mini-series about neurosustainability, Cambridge scholarship student, Mohamed Hesham Khalil sits down with Professor Agustín Ibáñez and Burcin Ikiz to connect the dots between climate, inequality, urban design, and the ageing brain.

They unpack the exposome and zoom into the built environment as the missing middle layer we can actually change.

“Scientists sometimes we use strange words for simple things.” — Professor Agustín Ibáñez

The exposome is the full set of environmental influences (physical, social, and economic) that shape our health and behaviour over time — and why the built environment is the missing “mesoscale” link between global forces (like climate change and inequality) and individual brain outcomes (like cognition, dementia risk, and mental health).

“I always see that the built environment itself maybe hasn’t been given the same attention… because… people spend around 90 percent of time indoors.” Mohamed Hesham Khalil

Th...

What if sustainability wasn’t only about carbon, materials, and energy — but also about the human brain?

In this second episode of the mini-series about neuro-sustainability, neuroscience and architecture meet in a conversation that feels both urgent and surprisingly practical.

We investigate the work of Cambridge scholarship student, Mohamed Hesham Khalil, which we believe should be integrated into planning and architecture around the world.

“We can change diet, can change habits, but we cannot change a built environment. It’s built once and it lasts for tens of years.” Mohamed Hesham Khalil

In this episode, he is joined by Burçin Ikiz, who brings a climate-and-health lens to brain wellbeing across the lifespan.

Mohamed Hesham Khalil brings a design-and-research lens focused on environmental enrichment — and what our homes, streets, workplaces, and neighbourhoods are doing to us every day, whether we notice it or not.

This is not a theoretical chat. It’s about how we design environments that help brains thrive — especially as heat, pollution, and chronic stress become part of daily life for millions.

We like to think of brain health as something personal: sleep, diet, exercise, mindset. But the built environment is a long-term exposure — and it’s stubbornly permanent.

If your surroundings make movement hard, keep you indoors, overwhelm your senses, trap heat, or load the air with pollution — you don’t just “feel it.” Your brain does too.

1) What “environmental enrichment” means in the real world

This conversation translates neuroscience into design language: environments that support movement, stimulation, connection, and recovery.

“Don’t use it, you lose it. Just kind of like our muscles in our bodies.” Burçin Ikiz

2) The indoor reality we rarely talk about

If buildings are designed mainly for convenience and comfort, what happens to stimulation, mobility, and everyday brain engagement?

“When we spend like around 90 percent of time indoors… almost no chance for cognitive stimulation or physical activity through the building…” Mohamed Hesham Khalil

3) Heat, buildings, and brain function

As the climate warms, poorly adapted buildings become neurological stressors — not just uncomfortable boxes.

“If most of our buildings… have not been created for this increasingly warming world, it can be very, very hot indoors and that can really affect our brains.” Burçin Iki...

“The brain is not concrete… it is always changing.” Mohamed Hesham Khalil

We investigate the work of Cambridge scholarship student, Mohamed Hesham Khalil, which we believe should be integrated into planning and architecture around the world.

Mohamed also brings other top global experts to your ears during this short series of podcasts.

Neurosustainability and the built environment

In this opening episode, architect and Cambridge PhD candidate Mohammed Hesham Khalil introduces neurosustainability—a way of thinking about buildings and cities that asks how everyday environments shape mental health, cognition, stress levels, and long-term brain resilience.

“Sustainability… has to be inclusive and include the brain as well.” Mohammed Hesham Khalil

Jackie and Mohammed explore how the built environment influences us in ways we often overlook: the presence (or absence) of nature, whether our days include movement, how much variety and “spatial complexity” we experience, and how factors like air pollution can undermine health—even in places that look green on the surface.

This episode sets the foundation for the series: a practical, research-informed conversation about designing places that support the brain—not just the building.

Neurosustainability and the built environment

This episode is for anyone who makes decisions that shape how people live inside places—and anyone who’s felt, personally, that certain environments lift you up or drag you down.

“It’s not only about architecture… it’s about the way we live.” Mohamed Hesham Khalil

• Architects & designers (especially if you care about wellbeing beyond “light and air” checklists)

• Urban planners & transport planners working on walkability, density, public realm, and mobility

• Developers & project managers making trade-offs between cost, space, green features,...