As molecular profiling advances, precision oncology is reshaping cancer care for children, adolescents and young adults. In this episode of Cancer Advances, Prajwal Rajappa, MD, MS, discusses how genomic sequencing, methylation profiling and multidisciplinary molecular tumor boards are improving diagnostic accuracy, informing risk-adapted treatment decisions and uncovering new therapeutic opportunities. Discover how integrated data platforms are helping translate molecular insights into personalized patient care.

What does it take to establish the standard of care in oncology? Matt Kalaycio, MD, Vice Chair of the Cleveland Clinic Cancer Institute and Chair of the National Comprehensive Cancer Network (NCCN) Board of Directors, joins the Cancer Advances podcast to discuss how NCCN Guidelines are developed, updated and implemented across cancer care. Listen as he explores the role of multidisciplinary expertise, patient advocacy, clinical evidence and emerging AI-enabled tools in shaping oncology practice, policy and decision-making.

What happens when a cancer is deemed unresectable? In this episode, Dr. Haniee Chung discusses how multidisciplinary care is expanding treatment options for patients with advanced and recurrent rectal cancer. She highlights the role of tumor board review, neoadjuvant therapy, robotic surgery and specialized supportive services, and explains why referral to a dedicated multivisceral cancer program may uncover options previously thought impossible.