Hani Najm, MD, and Joanna Ghobrial, MD, discuss the evolving role of transcatheter pulmonary valve implantation in lifetime management of congenital heart disease patients. They explore patient selection, valve durability, imaging strategies for early detection of HALT or HAM and the collaborative heart team approach that optimizes outcomes.

Looking to refer a patient? Please reach out to our Physician Referral team Mon. - Fri., 8 a.m. - 5 p.m. (ET) at 855.751.2469.

Venugopal Menon, MD, Director of the Coronary ICU, and Michael Tong, MD, cardiothoracic surgeon specializing in advanced heart failure, discuss contemporary management of post-infarction ventricular septal rupture, a rare but serious complication. They review the role of early transfer to high-volume centers and why definitive surgical closure remains the gold standard. Learn about the impact of temporary mechanical circulatory support on organ recovery and the timing of repair.

Looking to refer a patient? Please reach out to our Physician Referral team Mon. - Fri., 8 a.m. - 5 p.m. (ET) at 855.751.2469.

Kenneth McCurry, MD, and Marie Budev, DO, share Cleveland Clinic’s multidisciplinary approach to managing end-stage lung disease and advancing lung transplantation. They discuss innovations such as ex vivo lung perfusion (EVLP), ECMO bridging, and strategies for expanding donor and recipient criteria, including complex and multi-organ cases. The episode also highlights ongoing research and clinical trials aimed at improving post-transplant outcomes and reducing chronic rejection.

Looking to refer a patient? Please reach out to our Physician Referral team Mon. - Fri., 8 a.m. - 5 p.m. (ET) at 855.751.2469.

Samir Kapadia, MD, Chairman of Cardiovascular Medicine at Cleveland Clinic, and David Zidar, MD, PhD, an interventional cardiologist and immunologist, introduce Cleveland Clinic’s Cardioimmunology Center, a new initiative focused on the intersection of immune pathways and cardiovascular disease. They discuss how immune system activity can influence heart health and discuss innovative approaches to identifying and managing cardiovascular risk through immunologic biomarkers.

Looking to refer a patient? Please reach out to our Physician Referral team Mon. - Fri., 8 a.m. - 5 p.m. (ET) at 855.751.2469.

Lee Kirksey, MD, Aravinda Nanjundappa, MBBS, MD, and G. Jay Bishop, MD, discuss a multidisciplinary approach to peripheral artery disease (PAD) management. They explore evidence-based strategies including early detection, optimal medical therapy, supervised exercise programs and advanced endovascular and surgical interventions, emphasizing team-based care and longitudinal follow-up for improved outcomes.

Looking to refer a patient? Please reach out to our Physician Referral team Mon. - Fri., 8 a.m. - 5 p.m. (ET) at 855.751.2469

Allan Klein, MD, and Tom Kai Ming Wang, MBChB, discuss the 2025 ACC Concise Clinical Guidance on pericardial disease. They explore updated diagnostic criteria, the role of multimodality imaging and a shift toward IL-1 blockers for recurrent pericarditis. Learn practical strategies to optimize patient outcomes and avoid misdiagnosis or undertreatment, along with insights on surgical options and emerging clinical trials.

Read about the new guidance. https://consultqd.clevelandclinic.org/resource-for-avoiding-misdiagnosis-and-undertreatment-in-pericarditis

Looking to refer a patient? Please reach out to our Physician Referral team Mon. - Fri., 8 a.m. - 5 p.m. (ET) at 855.751.2469

Lars Svensson, MD, PhD, and Xiaoying Lou, MD, share a deep dive into valve-sparing aortic root surgery, an advanced technique that preserves the patient’s native valve while treating aortic aneurysms.

Looking to refer a patient? Please reach out to our Physician Referral team Mon. - Fri., 8 a.m. - 5 p.m. (ET) at 855.751.2469.

Steven Nissen, MD, and Luke Laffin, MD, discuss a groundbreaking phase 1 trial of a CRISPR-Cas9 gene-editing therapy targeting ANGPTL3. They explore its potential as a one-time treatment to significantly lower LDL cholesterol and triglycerides, with promising safety and efficacy data that could reshape lipid management.

Learn more about C5 Research at Cleveland Clinic.
https://my.clevelandclinic.org/research/c5research

Looking to refer a patient? Please reach out to our Physician Referral team Mon. - Fri., 8 a.m. - 5 p.m. (ET) at 855.751.2469.