Lee Kirksey, MD, and J. Eduardo Corso, MD, examine the clinical impact of smoking on peripheral artery disease, aneurysmal disease and outcomes after vascular intervention, with emphasis on risk modification and evidence-based decision-making. The discussion highlights practical strategies for integrating smoking cessation conversations into patient visits, screening considerations and how nicotine use alters long-term procedural durability.

View smoking cessation resources.
https://my.clevelandclinic.org/departments/heart/patient-education/hvti-resources/smoking-and-your-health

Looking to refer a patient? Please reach out to our Physician Referral team Mon. - Fri., 8 a.m. - 5 p.m. (ET) at 855.751.2469.

This episode examines the clinical utility of cardiopulmonary exercise testing with emphasis on cardiac output, ventilatory efficiency, and metabolic responses to exercise. Cleveland Clinic experts discuss how CPET informs diagnosis, risk stratification and longitudinal management in pulmonary hypertension, complex cardiovascular disease and athletic populations.

Meet the presenters:
J. Emanuel Finet, MD - Principles of Metabolic Exercise Testing
Sanjeeb Bhattacharya, MD - Pulmonary Hypertension
Tamanna Singh, MD - Athlete’s Heart

Looking to refer a patient? Please reach out to our Physician Referral team Mon. - Fri., 8 a.m. - 5 p.m. (ET) at 855.751.2469.

Thomas Callahan, MD, and Shinya Unai, MD, discuss the role of cardiac surgical backup during transvenous lead extraction. The conversation examines risk stratification, preoperative planning and rescue strategies for vascular and cardiac injury.

Looking to refer a patient? Please reach out to our Physician Referral team Mon. - Fri., 8 a.m. - 5 p.m. (ET) at 855.751.2469.

Learn more at leadconnection.org.

Allan Klein, MD, and Deborah Kwon, MD, discuss contemporary guidance on pericarditis with emphasis on evolving diagnostic criteria, inflammatory syndromes and the role of multimodality imaging. The conversation explores risk stratification, medical treatment options and surgical decision-making in complex and recurrent disease.

Looking to refer a patient? Please reach out to our Physician Referral team Mon. - Fri., 8 a.m. - 5 p.m. (ET) at 855.751.2469.

Pasquale Santangeli, MD, PhD, and Arwa Younis, MD, discuss the clinical application of pulsed field ablation (PFA) for atrial fibrillation and ventricular arrhythmias. The conversation examines safety and efficacy benefits of PFA and the ongoing role of radiofrequency ablation in advanced electrophysiology practice.

Attending the Heart Rhythm Society conference? Visit Cleveland Clinic physicians at Booth #2134.

Looking to refer a patient? Please reach out to our Physician Referral team Mon. - Fri., 8 a.m. - 5 p.m. (ET) at 855.751.2469.

Luke Laffin, MD, and Steven Nissen, MD, discuss findings from SURPASS-CVOT, including a secondary analysis evaluating broader cardiovascular and renal outcomes with dual GLP-1 and GIP agonist therapy compared with a first-generation GLP-1 agent. The conversation examines outcomes of the therapy on all-cause mortality and the clinical implications for treating patients with diabetes and high cardiovascular risk.

View current clinical trials. https://my.clevelandclinic.org/departments/heart/clinical-trials

Looking to refer a patient? Please reach out to our Physician Referral team Mon. - Fri., 8 a.m. - 5 p.m. (ET) at 855.751.2469.

Steven Nissen, MD, and Luke Laffin, MD, discuss late-breaking data from the Phase II KARDINAL Trial evaluating Tonlamarsen, a once-monthly therapeutic for uncontrolled multidrug therapy. They review study design, blood pressure outcomes and the potential clinical role of long-acting injectable therapies to address adherence gaps in real-world hypertension management.

View current clinical trials. https://my.clevelandclinic.org/departments/heart/clinical-trials

Looking to refer a patient? Please reach out to our Physician Referral team Mon. - Fri., 8 a.m. - 5 p.m. (ET) at 855.751.2469.

Sean Lyden, MD, and Jon Quatromoni, MD, discuss the evolving landscape of vascular clinical trials, highlighting investigational therapies and device-driven innovations. Learn how these trials are shaping evidence-based decision-making, expanding minimally invasive options and influencing future standards of care for aortic, carotid, peripheral arterial and venous disease.

View current clinical trials. https://my.clevelandclinic.org/departments/heart/clinical-trials

Looking to refer a patient? Please reach out to our Physician Referral team Mon. - Fri., 8 a.m. - 5 p.m. (ET) at 855.751.2469.