Can the Microbiome Replace Ozempic? Two Experts Weigh In on a Radical Theory
with Dr. Gary Pepper & Mary Gocke, RDN, CDN, CHT

Are we overlooking the natural power of the gut microbiome in managing weight and metabolism?

In this eye-opening conversation, Dr. Gary Pepper — a seasoned endocrinologist — teams up with renowned nutritionist and functional medicine expert Mary Gocke to explore whether the body’s own microbiome might one day rival pharmaceutical GLP-1 drugs like Ozempic and Wegovy. From nutritional strategies to protect muscle and bone during weight loss, to the role of akkermansia and polyphenols in boosting natural GLP-1 production, this discussion offers a radically fresh perspective on sustainable metabolic health.

Topics covered in this episode include:

What GLP-1 medications like Ozempic actually do — and what they don’t

Why weight loss can lead to malnutrition, muscle loss, and even bone density decline

How the gut microbiome — especially Akkermansia muciniphila — may support natural GLP-1 production

The critical importance of dietary fiber, polyphenols, and prebiotics in metabolic health

How protein needs shift during rapid weight loss and how to calculate your target intake

Early evidence for and against the long-term use of GLP-1 drugs

The promising but controversial concept of microdosing and tapering off GLP-1s

Simple strategies to protect your body from the side effects of medical weight loss

Why resistant starches (like cooled potatoes and rice) might actually help your microbiome

The silent risk of osteoporosis from poorly managed weight loss

Whether you're currently on a GLP-1 medication, considering one, or exploring natural alternatives, this candid and science-based conversation will equip you with insights not found in mainstream media.

👉 Visit semagludiet.com to try the free Protein Intake Calculator tailored to your age, weight, activity level, and dietary needs.

📌 This podcast is for educational purposes only. Always consult your healthcare provider before making changes to your medical or nutritional plan.

Gary Pepper, M.D., an associate professor at a prominent medical school and endocrinologist with 40 years of experience, brings clarity to numerous topics within the field of metabolic health. His view points are unhindered by corporate interests, unlike many other current "thought leaders" in medicine. Dr. Pepper, a dedicated educator, established his homebase website www.metabolism.com in 1996 and has blogged on important topics since then. Not one to be left behind by technology he began podcasting in 2020 with the onset of the pandemic and continues publishing vlogs on YouTube at his channel metabolism123. So whatever your choice in media, you will be gaining fresh insights by tuning in to his opinionated shows or reading his blogs on critical health topics.