In this episode, Palak J. Trivedi, BSc, MBBS, PhD, MRCP, ESEGH​, discusses the most recent developments in primary biliary cholangitis (PBC) treatment, including cutting-edge data on new and emerging agents and how these updates may be integrated into your practice. Topics include:

• Steatotic liver disease and PBC
• Vibration-controlled transient elastography (VCTE) and discordant biochemical responses in PBC
• PPAR agonists and IBATs for PBC treatment

Presenter:

Palak J. Trivedi, BSc, MBBS, PhD, MRCP, ESEGH
Associate Professor
NIHR Birmingham BRC
University of Birmingham
Consultant Hepatologist, Liver Unit
University Hospitals Birmingham
Birmingham, United Kingdom

Link to full program:
https://bit.ly/4lKaO2H

Follow along with the slides:
https://bit.ly/44PPBys

Get access to all of our new podcasts by subscribing to the CCO Infectious Disease Podcast on Apple Podcasts, Google Podcasts, or Spotify.

Listen as expert faculty answer your most pressing questions on optimizing immunization in clinical practice.

Topics covered include:

• Practical methods for improving confidence in vaccines
• How to educate patients on vaccine development and safety monitoring
• Effective strategies to tailor recommendations, such as motivational interviewing
• Ways to navigate clinical encounters and address vaccine hesitancy

Presenters:
Robert H. Hopkins, Jr., MD, MACP
Professor of Internal Medicine and Pediatrics
University of Arkansas for Medical Sciences
College of Medicine
Little Rock, Arkansas

Litjen (L.J.) Tan, MS, PhD
Chief Policy and Partnership Office, Immunize.org
Chair, National Adult Influenza Immunization Summit
Co-Chair, Global Influenza Initiative
St Paul, Minnesota

Link to full program:
https://bit.ly/3I5jBh0

Get access to all of our new podcasts by subscribing to the CCO Infectious Disease Podcast on Apple Podcasts, Google Podcasts, or Spotify.

In this episode, Dr Gideon Hirschfield meets with patient advocate Jess Schnur to discuss challenges related to the diagnosis and management of primary biliary cholangitis (PBC) to provide actionable strategies for healthcare professionals to incorporate into patient care, including:

• Disease concerns and frequently asked questions from a patient perspective
• Managing symptoms
• Treatment options and supportive care
• Importance of awareness and education

Presenters:
Gideon Hirschfield, MA, MB BChir, FRCP, PhD
Lily and Terry Horner Chair in Autoimmune Liver Disease Research
Professor, Division of Gastroenterology and Hepatology
University of Toronto
Director, The Autoimmune and Rare Liver Disease Programme
Director, Francis Family Liver Clinic
Toronto General Hospital, University Health Network
Ontario, Canada

Jess N. Schnur, BSN-RN
National PBC Patient Advocate
American Liver Foundation
Donation Support Services Coordinator
Lifeline of Ohio
Columbus, Ohio

To learn more, see the program
Hear Me: Patient Perspectives on PBC

In this podcast, Sonal Kumar, MD, MPH, meets with patient advocate Maria Morais to discuss actionable steps that healthcare providers can incorporate into the care of people with primary biliary cholangitis (PBC). Listen as they discuss:

• The chronic nature of PBC
• Going beyond biochemical markers to assess and address symptoms such as fatigue and pruritus
• The importance of referral to patient support groups

Presenters:

Sonal Kumar, MD, MPH
Assistant Professor of Medicine
Director, General Gastroenterology and Hepatology
Weill Cornell Medical College
New York, New York

Maria G. Morais, RN
VP Patient Advocacy
Canadian PBC Society
Toronto, Canada

To learn more, see the program
Hear Me: Patient Perspectives on PBC

In this podcast, expert faculty, Dr Stuart Gordon and Dr Nancy Reau, use an illustrative patient case to explore the roles of ALP and other biochemical markers in PBC management, and explain what to expect from treatment. Topics covered include:

• How baseline ALP can affect ALP normalization after second-line treatment with elafibranor and seladelpar
• Potential outcomes if ALP normalization cannot be achieved
• The importance of managing fatigue, pruritus, and sleep disturbances independently of the biochemical response

Presenters:

Stuart C. Gordon, MD
Professor of Medicine
Wayne State University School of Medicine
Director, Division of Hepatology
Henry Ford Health
Detroit, Michigan

Nancy Reau, MD
Professor of Medicine
Richard B. Capps Chair of Hepatology
Chief, Section of Hepatology
Associate Director, Solid Organ Transplantation
Rush University Medical Center
Chicago, Illinois

To learn more about PBC management, check out our program,
Curbside Consults: Expert Insights on Challenges in PBC Management.

Supported by educational grants from Gilead Sciences, Inc. and Ipsen Biopharmaceuticals, Inc

In this podcast, expert faculty, Dr Stuart Gordon and Dr Nancy Reau discuss an illustrative patient case to demonstrate how they individualize primary biliary cholangitis (PBC) therapy for patients ​with cirrhosis. Topics covered include:

• AASLD guideline recommendations for second-line therapy for PBC
• Considerations when using newer agents for second-line treatment of PBC in patients with cirrhosis: elafibranor and seladelpar

Presenters:

Stuart C. Gordon, MD
Professor of Medicine
Wayne State University School of Medicine
Director, Division of Hepatology
Henry Ford Health
Detroit, Michigan

Nancy Reau, MD
Professor of Medicine
Richard B. Capps Chair of Hepatology
Chief, Section of Hepatology
Associate Director, Solid Organ Transplantation
Rush University Medical Center
Chicago, Illinois

To learn more about PBC management, check out our program,
Curbside Consults: Expert Insights on Challenges in PBC Management.

Supported by educational grants from Gilead Sciences, Inc. and Ipsen Biopharmaceuticals, Inc

In this podcast, Brett M. Elicker, MD, and David E. Griffith, MD, ATSF, FACCP, FRSM, discuss the pathophysiology of non–cystic fibrosis bronchiectasis (NCFBE), the patient burden, and best practices with diagnosing NCFBE, including:

• The vicious vortex of NCFBE (ie, airway dysfunction, inflammation, infection)
• Cough as the most significant symptom and burden
• Imaging bronchiectasis with classic and inflammatory findings
• Differentiating the causes of NCFBE to inform patient care

Presenters

Brett M. Elicker, MD
Professor of Clinical Radiology
Chief, Cardiothoracic Imaging Division
Department of Radiology & Biomedical Imaging
University of California, San Francisco
San Francisco, California

David E. Griffith, MD, ATSF, FACCP, FRSM
Professor of Medicine
Division of Mycobacterial and Respiratory Diseases
Department of Medicine
National Jewish Health
Denver, Colorado

Program page:
https://bit.ly/4mZbYsm

In this podcast, listen as experts Alan Bonder, MD, AGAF, and Aparna Goel, MD, discuss how they assess the symptoms of primary biliary cholangitis (PBC) and explore how new therapeutic agents may help alleviate symptom burden. Topics include:

• Strategies and tools for assessing pruritus
• Nonpharmacologic and pharmacologic management of pruritus
• Second-line agents and their impact on pruritus
• Investigational treatments for pruritus

Presenters:

Alan Bonder, MD, AGAF
Associate Professor of Medicine
Medical Director of Liver Transplant
Department of Gastroenterology
Beth Israel Deaconess Medical Center
Harvard Medical School
Boston, Massachusetts

Aparna Goel, MD
Associate Clinical Professor of Medicine
Division of Gastroenterology and Hepatology
Stanford University
Palo Alto, California

Content based on an online CME program supported by independent educational grants from Gilead Sciences, Inc., and Ipsen Biopharmaceuticals, Inc​.

To learn more about PBC management, check out our program, Curbside Consults: Expert Insights on Challenges in PBC Management.