『Breathwork: Sarcoidosis with Professor Anthony O'Regan (Part 2)』のカバーアート

Breathwork: Sarcoidosis with Professor Anthony O'Regan (Part 2)

Breathwork: Sarcoidosis with Professor Anthony O'Regan (Part 2)

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 In this episode, we delve into sarcoidosis with Professor Anthony O'Regan. We discuss the nuances of diagnosing sarcoidosis and revisit the pathophysiology of the condition. This episodes details the importance of follow up care and provides insights into how to tease out differentials. Furthermore, we address how to determine which patients should be treated, along with choice of treatments and duration. 00:15 Rapid fire round: sarcoidosis 00:45 Pathophysiology of sarcoidosis 05:30 Multisystem involvement in sarcoidosis 07:15 Granulomatous disease 09:00 Referral to respiratory clinic (Symptoms/Differentials/Family history/Travel) 10:30 Initial investigations 10:45 Coming to a diagnosis of sarcoidosis 14:05 The role of biopsy in diagnosis of sarcoidosis 15:50 Teasing out the differentials in follow up 17:35 When to treat in sarcoidosis 19:25 Duration of treatment 19:50 Relapse of disease 21:00 Starting dose of steroids 22:00 Disease modifying therapy 23:30 Antifibrotics 24:25 Follow up in sarcoidosis 25:01 The future of sarcoidosis Show Notes: - Judson MA, Baughman RP, Teirstein AS, Terrin ML, Yeager H Jr. Defining organ involvement in sarcoidosis: the ACCESS proposed instrument. ACCESS Research Group. A Case Control Etiologic Study of Sarcoidosis. Sarcoidosis, Vasculitis, and Diffuse Lung Diseases : Official Journal of WASOG. 1999 Mar;16(1):75-86. PMID: 10207945. - 40 consecutive patients in Ireland 20% end up on steroids - John Gibson study on steroids RCT Gibson GJ, Prescott RJ, Muers MF, Middleton WG, Mitchell DN, Connolly CK. "British Thoracic Society Sarcoidosis study: effects of long-term corticosteroid treatment." Thorax. 1996;51(3):238-247. DOI: 10.1136/thx.51.3.238 - Nintedanib in patients with progressive fibrosing interstitial lung diseases—subgroup analyses by interstitial lung disease diagnosis in the INBUILD trial: a randomised, double-blind, placebo-controlled, parallel-group trial Wells, Athol UAbe, S. et al. The Lancet Respiratory Medicine, Volume 8, Issue 5, 453 – 460 - ITS Flashcard Sarcoidosis https://irishthoracicsociety.com/wp-content/uploads/2022/02/15.-Sarcoidosis-30.11.21.pdf

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