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Aging-US

Aging-US

著者： Aging Podcast
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Aging is dedicated to advancing our understanding of the biological mechanisms that drive aging and the development of age-related diseases. Our mission is to serve as a platform for high-quality research that uncovers the cellular, molecular, and systemic processes underlying aging, and translates these insights into strategies to extend healthspan and delay the onset of chronic disease. Read about the Aging Scientific Integrity Process: https://aging-us.com/scientific-integrityAll rights reserved 科学
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  • New Control Theory Framework Proposes a Safer Approach to Aging Drug Discovery

    New Control Theory Framework Proposes a Safer Approach to Aging Drug Discovery
    2026/10/15
    BUFFALO, NY — October 15, 2026 — A new #research paper was #published in Volume 18 of Aging on September 16, 2026, titled “Control theory of aging and longevity for gerotherapeutic drug discovery: state space, vector fields, modalities, safety, and the minimum safe cost of functional restoration.” The paper introduces a mathematical framework for understanding aging and guiding the development of therapies aimed at preserving or restoring biological function. By applying principles from control theory, the researchers propose evaluating treatments according to their ability to move aging biological systems toward healthier functional states while accounting for treatment risks, intervention timing and irreversible damage. The research was led by Aging Editorial Board member Alex Zhavoronkov, affiliated with Insilico Medicine and the Buck Institute for Research on Aging. Aging research has identified numerous biological processes that contribute to functional decline, including cellular senescence, mitochondrial dysfunction, chronic inflammation, epigenetic alterations and loss of proteostasis. Established frameworks, such as the Hallmarks of Aging and the hyperfunction theory developed by Mikhail Blagosklonny, have helped explain these changes. However, identifying aging-related mechanisms does not automatically determine how, when or whether they should be targeted therapeutically. The authors propose addressing this challenge using control theory, a mathematical discipline concerned with directing dynamic systems toward desired states. Their framework introduces the concept of biological state space, representing an organism’s condition across multiple dimensions, including inflammation, mitochondrial function, epigenetic stability, immune competence and regenerative capacity. Rather than aiming to restore every molecular feature to a youthful state, the framework prioritizes maintaining or recovering acceptable physiological function. Full press release - https://www.aging-us.com/news-room/new-control-theory-framework-proposes-a-safer-approach-to-aging-drug-discovery DOI - https://doi.org/10.18632/aging.206422 Corresponding author - Alex Zhavoronkov - alex@insilicomedicine.com Abstract video - https://www.youtube.com/watch?v=qXL5LMhQTVs Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206422 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, control theory, biological age, drug discovery, gerotherapeutics To learn more about the journal, please visit https://www.Aging-US.com​​ and connect with us on social media at: Bluesky - https://bsky.app/profile/aging-us.bsky.social ResearchGate - https://www.researchgate.net/journal/Aging-1945-4589 X - https://twitter.com/AgingJrnl Facebook - https://www.facebook.com/AgingUS/ Instagram - https://www.instagram.com/agingjrnl/ LinkedIn - https://www.linkedin.com/company/aging/ Reddit - https://www.reddit.com/user/AgingUS/ Pinterest - https://www.pinterest.com/AgingUS/ YouTube - https://www.youtube.com/@Aging-US Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM
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    9 分
  • Longevity & Aging Series (S4, E7): Dr. Irina Conboy and Dr. Zachery Robinson

    Longevity & Aging Series (S4, E7): Dr. Irina Conboy and Dr. Zachery Robinson
    2026/10/15
    In this episode of the Longevity & Aging Series (S4, E7), Dr. Irina Conboy and Dr. Zachery Robinson from the Department of Bioengineering and QB3 Institute at UC Berkeley, CA, join host Dr. Yuan Zhao to discuss their research paper, published in Volume 18 of Aging, titled “Selective targeting of cancer and senescence via shared metabolic shifts extends lifespan of old mice.” DOI - https://doi.org/10.18632/aging.206399 Corresponding author - Irina M. Conboy - irina@generationlab.co Video interview - https://www.youtube.com/watch?v=wllQRXPq_sY Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206399 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, senescence, cancer, metabolic shift, ATP To learn more about the journal, please visit https://www.Aging-US.com​​ and connect with us on social media at: Bluesky - https://bsky.app/profile/aging-us.bsky.social ResearchGate - https://www.researchgate.net/journal/Aging-1945-4589 X - https://twitter.com/AgingJrnl Facebook - https://www.facebook.com/AgingUS/ Instagram - https://www.instagram.com/agingjrnl/ LinkedIn - https://www.linkedin.com/company/aging/ Reddit - https://www.reddit.com/user/AgingUS/ Pinterest - https://www.pinterest.com/AgingUS/ YouTube - https://www.youtube.com/@Aging-US Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM
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    36 分
  • Exceptional Longevity Across Species Linked to DNA Maintenance, Stemness and Stress Resistance

    Exceptional Longevity Across Species Linked to DNA Maintenance, Stemness and Stress Resistance
    2026/09/24
    BUFFALO, NY — September 24, 2026 — A new #review was #published in Volume 18 of Aging on September 8, 2026, titled “How to live for centuries: common denominators of organisms with exceptional longevity.” The review examines what some of the world’s longest-lived organisms may reveal about the biology of exceptional longevity. The review was led by first author Stefania E. Kapsetaki from the Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas (FORTH), in Heraklion, Crete, Greece. Corresponding author Nektarios Tavernarakis is affiliated with the same institute and with the Division of Basic Sciences, School of Medicine, University of Crete. Kapsetaki and Tavernarakis surveyed molecular and cellular evidence from 101 multicellular species with maximum lifespans of at least 250 years, including 90 plants and 11 animals. Some reach only slightly beyond 250 years, while others may persist for thousands or even tens of thousands of years. The freshwater planarian Schmidtea mediterranea and the jellyfish Turritopsis dohrnii are even considered potentially immortal. Rather than looking only at why certain species live longer than others, the authors compared two dimensions of longevity: variation within exceptionally long-lived species and variation between long- and shorter-lived species. Their analysis covered genetic, genomic, transcriptomic, proteomic and metabolomic findings, as well as telomere maintenance, stress resistance, regeneration and tumorigenesis. Full press release - https://www.aging-us.com/news-room/exceptional-longevity-across-species-linked-to-dna-maintenance-stemness-and-stress-resistance DOI - https://doi.org/10.18632/aging.206419 Corresponding author - Nektarios Tavernarakis - tavernarakis@imbb.forth.gr Abstract video - https://www.youtube.com/watch?v=VvzjvzQj-Qk Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206419 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, healthspan, interspecific variation, intraspecific variation, stemness To learn more about the journal, please visit https://www.Aging-US.com​​ and connect with us on social media at: Bluesky - https://bsky.app/profile/aging-us.bsky.social ResearchGate - https://www.researchgate.net/journal/Aging-1945-4589 X - https://twitter.com/AgingJrnl Facebook - https://www.facebook.com/AgingUS/ Instagram - https://www.instagram.com/agingjrnl/ LinkedIn - https://www.linkedin.com/company/aging/ Reddit - https://www.reddit.com/user/AgingUS/ Pinterest - https://www.pinterest.com/AgingUS/ YouTube - https://www.youtube.com/@Aging-US Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM
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    7 分
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