In this episode of 'It's Not In Your Head', Dan and Justine delve into the complex relationship between hypermobile Ehlers-Danlos Syndrome (hEDS) and central sensitization, focusing on hEDS as an example of a metabolic driver. Dan shares personal insights from his practice and elaborates on the common patterns and markers identified in patients with hEDS, how it should be diagnosed and treated, and associated challenges. Justine adds her perspective, particularly on the connection between CRPS and hypermobility, and lifestyle interventions. They explore the underlying mechanisms, preventive strategies and management techniques, emphasizing the importance of protein intake, avoiding certain drugs, and considering genetic predispositions. With expert advice and a touch of humor, this episode provides a comprehensive look at managing the very complicated disorder that is hEDS.

00:00 Introduction to the Podcast

01:00 Diving into Central Sensitization and hEDS

02:25 Understanding EDS Types

03:39 Dan's Journey with Hypermobile EDS Patients

04:50 Identifying Patterns in Complex Patients

05:25 Exploring the Underlying Disease Process

08:39 Mechanisms Behind Hypermobile EDS

09:52 The Role of Protein Metabolism in EDS

11:13 MMPs and Their Impact

18:42 Inflammatory Responses and Immune System Involvement

26:22 Genetic Predispositions and External Triggers

31:13 Understanding Protein Requirements

32:38 Strategies for Increasing Protein Intake

36:20 Choosing the Right Protein Sources

40:47 Long COVID and Hypermobility

46:17 Preventing Disease Progression

54:42 Final Thoughts and Future Directions

Resources:

www.iniyh.com/episodes/ep-30-making-sense-of-heds