Sydney Shaw, like every single woman in New York, has terrible luck with dating. She’s seen it all: men who lie in their dating profile, men who stick her with the dinner bill, and worst of all, men who can't shut up about their mothers. But finally, she hits the jackpot. Her new boyfriend is utterly perfect. He's charming, handsome, and works as a doctor at a local hospital. Sydney is swept off her feet. Then the brutal murder of a young woman—the latest in a string of deaths across the coast—confounds police. The primary suspect? A mystery man who dates his victims before he kills them.

Deep in the African rain forest, near the legendary ruins of the Lost City of Zinj, an expedition of eight American geologists are mysteriously and brutally killed in a matter of minutes. Ten thousand miles away, Karen Ross, the Congo Project Supervisor, watches a gruesome video transmission of the aftermath: a camp destroyed, tents crushed and torn, equipment scattered in the mud alongside dead bodies - all motionless except for one moving image - a grainy, dark, man-shaped blur.

Ryland Grace is the sole survivor on a desperate, last-chance mission - and if he fails, humanity and the Earth itself will perish. Except that right now, he doesn't know that. He can't even remember his own name, let alone the nature of his assignment or how to complete it. All he knows is that he's been asleep for a very, very long time. And he's just been awakened to find himself millions of miles from home, with nothing but two corpses for company.

After the killing of a prominent mob lawyer, NYPD homicide detectives Jacob Jackson and Caitlin Grimes start receive chilling, written “rules” for how to commit the perfect murder. "Rule number one for the perfect murder: Evidence is your enemy. Leave none behind." Jackson (Reid Scott) and Grimes (Cobie Smulders) race to find the killer, setting them on a collision course with the city’s crime underbelly, and a perpetrator who seems happy to toy with them. “Rule number two. No crimes of passion. The perfect murder is always business, never pleasure.”

With money and hope in short supply, newly minted attorney Brigham Theodore decides it’s time to lower his standards. He joins a seedy fly-by-night firm in Salt Lake City out of desperation. After he loses his first case - a speeding ticket - he’s convinced his career is over. But to his shock, his boss hands him a slightly more complex case: capital murder.