Early in 1799, Napoleon advanced against France’s erstwhile enemy, the Ottoman Empire, invading modern Syria (then the province of Damascus) and conquering the cities of Gaza, Jaffa, Arish and Haifa. However, with the plague running rampant through his army and his lines of supply from Egypt stretched dangerously thin, Napoleon was unable to destroy the fortified city of Acre and was forced to retreat. The retreat cost him almost all of his wounded as, harassed by enemy forces, he was forced to abandon most of his casualties to the Ottomans’ mercy, or lack thereof. Most of the wounded were tortured and beheaded.

Upon returning to Cairo, Napoleon finally received dispatches from France which, with the Mediterranean rife with Royal Navy vessels, had been severely delayed. The dispatches told of renewed hostilities with Austria and her allies, and a series of defeats in Italy which had virtually annihilated all of Napoleon’s previous hard-won gains in the Italian peninsula. Leaving his army under the command of his subordinate General Kleber, Napoleon took advantage of a lull in the Royal Navy blockade and embarked upon one of his remaining ships. He set sail for France, where he would take absolute power within weeks of his return.

Though Napoleon’s unquenchable thirst for military adventurism eventually cost him both his throne and his freedom during the Napoleonic Wars of the late 18th and early 19th centuries, the French emperor was not easily defeated even when most of Europe's nations united against him. Two military setbacks on a scale unprecedented in history until then were required before the high tide of Napoleon's success began to ebb towards the final denouement of the Hundred Days and the famous battle of Waterloo.

Although Napoleon was exiled after Leipzig, he was allowed to retain the title of Emperor and was given de facto control over Elba.