Coma Sins is a fictional story about a seriously ill man. Ben Bluman is middle-aged and suffers from untreated schizophrenia.

The tale starts with two policemen who, while driving drunk on a particularly nasty night, run into a pedestrian trying to cross a street. Afraid that the man is dead, they try to conceal his body. But the man is not hurt seriously. Suddenly awake yet unable to control his actions, he murders both policemen. Later that same early morning, partly dazed by the accident, he falls against a fire hydrant and passes out.

For the next ten days Ben Bluman is lying unconscious, in a coma, in St. Bernard's Hospital in Chicago. And during that time he relives various parts of his life. He recalls being offered the job of a lifetime in a small and rising company. He remembers being hired on the spot, as CFO and Vice President. He remembers the owner, Bob Janklaw, the employment manager, James Sims and Mary White, Bob's assistant, the brains of the operation. He also recalls the moments of his madness in a local hotel room, where he sees the monstrous image of himself in the hotel room mirror. Those are the moments when he decides to destroy the leadership of the company and the company itself. His plans work out and Janklaw's, Sims' and Mary White's violent deaths are the climax of his rampage. At that point, he seeks help at a hospital for the insane.

This time, however, instead of being treated, he becomes a guinea pig in a government experiment with the seriously deranged, controllable killers. Sent to a special clinic and then fed experimental drugs, he eventually murders a politically inconvenient journalist at the New York Times.

When Bluman finally wakes up from his coma and runs from the hospital, he tries to reenter the world of normalcy though only partly medicated. As a consequence, his insane dreams and sickness continue to hound him. For a few months he works as a private eye in his half-dream state but, during the few moments of his uncontrolled insanity, he confronts a higher up officer of the Salvation Army in Chicago, and without a real cause for his angry outburst, he brutally murders her.

In his last moments of madness, he causes death and destruction at a children's amusement park. Finally, when faced by the police, by now on his tracks, he commits suicide by throwing himself out of his third floor apartment window.