検索キーワード： 著者 "Annenberg Center for Health Sciences" すべてのカテゴリー

Survival outcomes for patients with HR+/HER2- mBC remain suboptimal, despite first-line treatment strategies with endocrine therapy (ET). Greater understanding of the biology of HR+/HER2- mBC, including the role of biomarkers like ESR1 mutations, and the development of biopsy techniques for early mutation detection, have paved the way for personalized treatment approaches. In this activity, medical oncologists discuss integrating these evidence-based advancements into practice.

Pruritus occurs in up to 70% of patients with primary biliary cholangitis (PBC), can be severe, and lead to increased morbidity-including worsening fatigue and quality of sleep. Standard of care treatment has relied on a variety of medications with limited effectiveness and tolerability adding to the patient disease burden. Alan Bonder, MD, and Kris Kowdley, MD, discuss unmet patient needs, pruritus assessment tools, and guideline-based therapy provided by an interprofessional care team.

The gut microbiome is recognized as playing a key role in infant health. Alessio Fasano, MD, world-renowned for his research on the gut microbiome focuses on the ways in which the gut microbiome influences allergy and autoimmunity. The effects of infant nutrition on the composition of the microbiome are also discussed, including the impact of feeding mode and probiotic and prebiotic supplementation.

Renowned professor of pediatric gastroenterology and nutrition, and endowed chair in pediatric research, Fayez K. Ghishan, MD, discusses the important role gastrointestinal microbiota plays in the development of immune function.

Anna Nowak-Wegrzyn, MD, PhD, takes a case-based approach to identify and diagnose food protein-induced enterocolitis syndrome (FPIES) in infants and how to manage acute reactions.

In this in-depth review, presented by Princess Ogbogu, MD, and developed in collaboration with Michael Wechsler, MD, MMSc, the wide-ranging presentations of HES will be reviewed, along with pathophysiology, classification, and acute and chronic management. Learnings from the presentation will be tied together with a case-based presentation of idiopathic HES, allowing learners to see how guideline recommendations and novel clinical trials can be applied in a real clinical setting.

Cold Agglutinin Disease is a rare, chronic hemolytic disorder, representing approximately 20% of all autoimmune hemolytic anemias. Catherine M. Broome, MD, and Alexander Röth, MD, provide an understanding of the pathogenesis of this disorder caused by cold-reacting IgM autoantibodies and reveal common clinical features. Because of the high mortality rate among those suffering from CAD, it is important to be aware of the diagnostic criteria, as well as the current and novel treatment options, with the goal of increasing hemoglobin levels, avoiding the need for transfusions, and improving ...

Obesity experts Drs. Apovian and Kushner delve into the complex and undertreated disease of obesity, addressing the importance of weight loss and chronic weight management. They discuss obesity as a chronic disease with its pathophysiologic basis, associated cardiometabolic risks, treatment options including pharmacotherapy, focusing on incretin-based medications, optimizing weight loss and maintenance, and how to approach patients about obesity.

Acid sphingomyelinase deficiency (ASMD) is a lysosomal storage disorder that causes accumulation of sphingomyelin in various organs. In addition to a low incidence, ASMD has a heterogeneous presentation that makes management challenging. Join experts Margaret McGovern, MD, PhD, and Pramod Mistry, MD, PhD, in this review of the diagnosis and treatment of patients with ASMD.

Thyroid eye disease, also known as Graves’ orbitopathy, is a potentially serious, progressive autoimmune disease that most often occurs in people with hyperthyroidism, ie, Graves’ disease. Kimberley Cockerham, MD, FACS, moderates this series of six, paired conversations between endocrinologist Terry J. Smith, MD, and eye specialists Wendy W. Lee, MD, and Raymond Douglas, MD, PhD, to explore current and emerging treatment options for thyroid eye disease. In these conversations, faculty review the current understanding of the burden and pathophysiology of thyroid eye disease—including ...

In this activity, Jeremy Abramson, MD, highlights the significant disease burden of B-cell lymphomas, as well as the latest advances in therapeutics, and practical strategies for integrating novel therapies into practice through patient selection and supportive care management.

Human breast milk is comprised of several bioactive components, including human milk oligosaccharides (HMOs), which are non-nutritive carbohydrates unique to human milk. In this course, Lars Bode, PhD, introduces HMOs and describes the structure, composition, and infant health benefits of these compounds. Topics include the prebiotic effects of HMOs, particularly related to the gastrointestinal and immune systems, but also growth and development and allergies. Also reviewed are the oligosaccharides found in infant formulas, with a focus on clinically relevant inform

Myasthenia gravis, an autoimmune disease characterized by fluctuating muscle weakness, greatly impacts patients’ functioning and activities of daily living. Important treatment advances continue to be made to reduce patient burden of disease and overcome safety, efficacy, and other limitations of available therapies. Join Nicholas Silvestri, MD, as he reports on research results of some of these advances presented at the 2024 American Association of Neuromuscular & Electrodiagnostic Medicine Annual Meeting.

Patients with long-chain fatty oxidation disorders (LC-FAODs) have historically been treated with diet modification and even-carbon medium-chain triglyceride (MCT) supplementation. In this 45-minute, case-based, modular activity, Sandra van Calcar, PhD, RD, LD, and Jerry Vockley, MD, PhD, address key topics, including disease presentation, historical treatment, emerging treatment with triheptanoin, and nutritional planning specific to patients with LC-FAODs.

Definition of excessive crying in infancy (ie, infant colic) Short- and long-term consequences of infant colic Connections between gut immaturity, dysbiosis, and colic Clinical management of infant colic Support for caregivers of infants with colic

Differentiating GER from GERD in infants The challenges of obtaining a definitive diagnosis of GERD Nonpharmacologic and nutritional management of GERD Practice pearls for thickened feeds Risks of acid-suppressive medications in infants GER and GERD case studies

Greater understanding and implementation of molecular biomarkers in non-small cell lung cancer (NSCLC) have led to improved patient outcomes. However, optimizing therapeutic strategies for patients with a molecular alteration continues to be challenging for the multidisciplinary team. Among these alterations, ROS1 rearrangements are rare, but have important clinical implications.

John Colombo, PhD, answers questions related to infant brain development and cognition. Fayez K. Ghishan, MD answers questions related to Milk Fat Globule Membrane (MFGM) Sean C.L. Deoni, PhD answers questions related to Docosahexaenoic acid (DHA)

In the first few weeks of life, the optimal growth rate for preterm infants is nearly twice that of term infants. To achieve this rapid rate of growth, preterm infants have high energy, protein, and micronutrient requirements. However, variability in human milk composition and inadequate fortification practices often result in suboptimal nutrition intake during these early critical weeks.

An interprofessional faculty of gastroenterology clinicians discuss real-world issues in managing patients with primary biliary cholangitis. Two mini-lectures serve as the foundation for understanding the diagnostic evaluation and risk factors of primary biliary cholangitis.