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Food and Drug Administration approval for COVID-19 vaccines and the controversial Alzheimer's drug Aduhelm made headlines, but few of us know much about how the agency does its work. Why is the FDA the ultimate United States authority on a drug's safety and efficacy? In Drugs and the FDA, Mikkael Sekeres—a leading oncologist and former chair of the FDA's cancer drug advisory committee—tells the story of how the FDA became the most trusted regulatory agency in the world.

In 1991, the United States was the only global superpower. It seemed that the 21st century, like the 20th, would belong to America. Then came the stock market bubble, the costly foreign unilateralism of the younger Bush presidency, and the financial catastrophe of 2008. Meanwhile, China was rising and the Middle East was awakening politically. Today it is clear that America is vulnerable - to domestic and international decline and unregulated greed.

30年近く続いたポスト冷戦時代は、時代に乗り遅れた日本の長期低迷時代でもあった。しかし米中対立を軸とする新冷戦時代で、いままでの日本のピンチが逆に大チャンスになる。

#1 New York Times Bestseller In Being Mortal, bestselling author Atul Gawande tackles the hardest challenge of his profession: how medicine can not only improve life but also the process of its ending Medicine has triumphed in modern times, transforming birth, injury, and infectious disease from...

On balance, will AI help humanity or harm it? AI could revolutionize science, medicine, and technology, and deliver us a world of abundance and better health. Or it could be a disaster, leading to the downfall of democracy, or even our extinction. In Taming Silicon Valley, Gary Marcus, one of the most trusted voices in AI, explains that we still have a choice. And that the decisions we make now about AI will shape our next century.

In this classic work of economic history and social theory, Karl Polanyi analyzes the economic and social changes brought about by the great transformation of the Industrial Revolution. His analysis explains not only the deficiencies of the self-regulating market, but the potentially dire social consequences of untempered market capitalism. New introductory material reveals the renewed importance of Polanyi's seminal analysis in an era of globalization and free trade.

In this important book, an eminent authority presents a new perspective on affirmative action, investigating its actual consequences in the United States and in other countries where it has been in effect. Evaluating his empirical data, Thomas Sowell concludes that race preference programs worldwide have not met expectations and have often produced the opposite of what was originally intended.

In The Alien, reformer and former U.S. immigration official Frederic C. Howe challenges the fear, prejudice, and economic exploitation surrounding immigration in early twentieth-century America. Howe argues that the so-called “immigration problem” is fundamentally economic rather than racial...

From four-term Oklahoma City Mayor Mick Cornett, a hopeful and illuminating look at the dynamic and inventive urban centers that will lead the United States in coming years. Oklahoma City. Indianapolis. Charleston. Des Moines. What do these cities have in common? They are cities of modest size...

Prominent military historian Victor Davis Hanson explores the nature of leadership with his usual depth and vivid prose in The Savior Generals, a set of brilliantly executed pocket biographies of five generals (Themistocles, Belisarius, William Tecumseh Sherman, Matthew Ridgway, and David Petraeus) who single-handedly saved their nations from defeat in war. War is rarely a predictable enterprise - it is a mess of luck, chance, and incalculable variables. Today's sure winner can easily become tomorrow's doomed loser.

Master the hidden systems of urban planning and sustainable design to transform your daily commute and local community. Whether you are waiting for a delayed bus, renting a downtown apartment, or walking through your neighborhood, the invisible rules of civic design impact your everyday life...

Welcome to 2030. I own nothing, have no privacy, and life has never been better. This is the vision of the Great Reset, according to globalist leaders. While proponents of the Great Reset push slogans like “Build Back Better”, “The Fourth Industrial Revolution”, and “A New Normal”, the Reset is nothing short of a rebranded Soviet system, threatening to strip away property rights, restrict freedom of movement and association, and radically reshape our diets and way of life.

Once described by Mao Zedong as a "needle inside a ball of cotton", Deng was the pragmatic yet disciplined driving force behind China's radical transformation in the late 20th century. He confronted the damage wrought by the Cultural Revolution, dissolved Mao's cult of personality, and loosened the policies that had stunted China's growth. Obsessed with modernization, Deng opened trade relations with the West, which lifted hundreds of millions out of poverty. Yet he also answered to his authoritarian roots, most notably when he ordered the crackdown in 1989 at Tiananmen Square.

Ein Fischer verschwindet vor der Küste Peru spurlos. Ölbohrexperten stoßen in der norwegischen See auf merkwürdige Organismen, die hunderte Quadratkilometer Meeresboden in Besitz genommen haben. Währenddessen geht mit den Walen entlang der Küste British Columbias eine unheimliche Veränderung vor. Nichts von alledem scheint miteinander in Zusammenhang zu stehen. Doch Sigur Johanson, norwegischer Biologe und Schöngeist, glaubt nicht an Zufälle.

A call to save ourselves and our planet by targeting the root of our inaction: extreme shortsightedness. 

Donald Trump promised the American people a transformative change in economic policy after eight years of stagnation under Obama. But he didn’t adopt a conventional left or right economic agenda. His is a new economic populism that combines some conventional Republican ideas–tax cuts...

If Lady Justice is blind, what guides her steps? Is justice, like beauty, in the eye of the beholder? Or are there objective criteria we can apply? What is the relationship between law and justice? Using works of literature, scenes from films, and actual cases as springboards for reflection and debate, Perceptions of Justice provides us with an easy-to-comprehend and entertaining critique of the American justice system.

This program is read by the author. The mental wellbeing of our children is shockingly poor. Marc Brackett, author of Permission to Feel, knows why. And he knows what we can do. "We have a crisis on our hands, and its victims are our children." Marc Brackett is a professor in Yale University’s...

Growing up in a New Jersey factory town in the 1980s, Daisy Hernández believed that her aunt had become deathly ill from eating an apple. No one in her family, in either the United States or Colombia, spoke of infectious diseases, and even into her 30s, she only knew that her aunt had died of a rare illness called Chagas. But as Hernández dug deeper, she discovered that Chagas - or the kissing bug disease - is more prevalent in the United States than the Zika virus. 

Enough of the imbalance that is causing the degradation of our environment, the demise of our democracies, and the denigration of ourselves. Enough of the pendulum politics of left and right and paralysis in the political center. We require an unprecedented form of radical renewal. In this book Henry Mintzberg offers a new understanding of the root of our current crisis and a strategy for restoring the balance so vital to the survival of our progeny and our planet.