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Holmes and Watson travel to Bristol to investigate a murder. In the prestigious Walsingham School, a boarding school for young women of status, where the French teacher was brutally assaulted. Local Police are in the dark and the school principal asks the famous detective and his dear friend Watson from London for help.

A seriously ill man, who is firmly convinced that he has been cursed by three witches, asks Sherlock Holmes to investigate. Convinced that their client must have an explainable cause for his illness Holmes and Watson are traveling to Eastbourne to get to the bottom of this, before their client departs from life.

Sherlock Holmes and Dr. Watson visit "Buffalo Bill's Wild West Show", which is on a big tour through the Empire. During the show, however, one of the Performers, who was acting as Ghost Dog, Chief of the Lakota tribe, mysteriously falls from his horse and succumbs to his injuries. Colonel William F. Cody instructs Holmes to investigate the incident.

Sherlock Holmes and Dr. Watson are assigned to investigate a strange poisoning, and although the relation between the victim, the crime and the motive offer some mystery and surprises, they are able to step by step close in on to solving the case. But then, Holmes' life gets into danger.

A colleague of Dr. Watson asks Sherlock Holmes for help: His patient Joseph Merrick, known in public as the "elephant man", because of his strong physical deformations, was the victim of a brutal assault. Holmes and Watson take over the case, which takes them to the circus milieu.

It is summer of 1885. The Strauss brothers are staying in London as part of a concert tour. The planned performance in one of the largest concert halls in the Empire is at jeopardy, when a crime occurs involving Johann's violin. His desperate brother Eduard reaches out to Sherlock Holmes for help.

After a series of attacks on the Ottoman administration in Palestine, Sherlock Holmes receives an order from the British government: he is to travel to Jerusalem with Dr. Watson to track down the disruptors and prevent any further destabilization of the region.

Disguised as Diplomats and on behalf of the British Intelligence Holmes and Watson attend the Congo Conference in Berlin. But when a high ranking representative disappears without a trace, the Congress threatens to fail. The German Chancellor, Bismarck, urges Holmes for help.

When the Crown Prince of Portugal visits London, a precious diamond, the Iguana's Tear, is stolen from him. Faced with the possibility of a devastating financial and political backlash for the Iberian Royal Family, Holmes and Dr. Watson are brought in to investigate matters before they escalate.

2. Inside the Prisoner's Carriage: Inspector Lestrade brings Holmes and Watson to Twickenham, where they investigate a murder case in the convent. If they can even make it there...

A few days before Christmas Inspector Lestrade is asking Holmes for assistance in a strange murder case. The extremely challenging and downright dangerous investigation leads them to a catholic abbey in Middlesex, where evil strikes terror into people's hearts.

7. The Librarian: The Confession brings no further clues. After Brother Nicholas promises key information, Holmes and Watson are visiting the impressive and ancient Library.

4. The Mortal Vessel: Holmes and Watson begin with their investigation. They visit the crime scene, the victims dorm room and inspect the body. In the process Holmes makes a discovery.

5. The Last Supper: Holmes is addressing all of the monks in the dining room, and the Abbot asks all his fellow Friars to go to confession, as an attempt to identify the perpetrator.

8. Genetics: When the Librarian is murdered too, Holmes is at a loss at first. But then he finds a book at the crime scene, with contents that could profoundly question Christian faith.

4. The Mortal Vessel: Holmes and Watson begin with their investigation. They visit the crime scene, the victims dorm room and inspect the body. In the process Holmes makes a discovery.

9. The Questioning: Inspector Lestrade is asking each and every Friar to take part in an interrogation, led by Inspector Lestrade. Holmes and Watson are only asked to assist. However the questioning does not turn out the way the Inspector expected.

3. In the Convent: After finally reaching the Redeemer's Abbey, the Abbot welcomes them and promptly fills them in about the gruesome details concerning the murder of Brother Emanuel.

A few days before Christmas Inspector Lestrade is asking Holmes for assistance in a strange murder case. The extremely challenging and downright dangerous investigation leads them to a catholic abbey in Middlesex, where evil strikes terror into people's hearts.

6. Confession: A fire erupts in the Chapel, which the Friars are able to extinguish. However, the Confessionals can still take place. Meanwhile Holmes has contact with an important witness.