William Sonntag: Roles for Growth Hormone and IGF1 in Neuroplasticity, Aging, and Disease
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William Sonntag: Roles for Growth Hormone and IGF1 in Neuroplasticity, Aging, and Disease
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Growth hormone (GH) is produced by cells in the pituitary gland and released into the blood where it travels to the liver and therein stimulates the production of insulin-like growth factor 1 (IGF1). The release of GH which occurs in a pulsatile manner is controlled by neurons in the brain. The GH – IGF1 neuroendocrine system is critical for normal growth of the body during development. During his career, University of Oklahoma Professor Bill Sonntag's laboratory has established that IGF1 production declines during aging and that IGF1 acts on brain cells in ways that promote synaptic plasticity and learning and memory. In this episode I talk with Bill about IGF1's roles in neuroplasticity and brain aging, how IGF1 may affect neuronal network activity and enhance resistance of neurons to stress, and how this knowledge may applied to counteracting aging and bolstering brain function.
LINKS:
Sonntag's University of Oklahoma webpage: https://www.ouhealth.com/research-experts/william-e-sonntag-phd/
Review article on GH – IGF1 and the brain:
https://pmc.ncbi.nlm.nih.gov/articles/PMC4388761/pdf/nihms639724.pdf
Original research articles relevant to this podcast:
https://pubmed.ncbi.nlm.nih.gov/?term=sonntag+w+igf-1+brain&sort=date&size=200