Week 10 College Football Predictions | Guessing Spreads, Over Unders, and Winners

Chandler, Ryan, and Aaron are back on Run After Cast to predict a packed college football slate, guess the spreads and over/unders, and pick winners. With playoff implications across the schedule, the crew debates which ranked teams can handle the pressure—and where an upset might be brewing. Expect close calls, conflicting picks, and Aaron’s uneasy prediction for Mississippi State.

• No. 9 BYU vs. No. 3 Utah: The show opens with a ranked rivalry and a debate over whether BYU can cover, even if Utah wins.
• Arkansas at Auburn: The hosts discuss Auburn’s chance to get its offense going, while Aaron picks Arkansas to cover and expects a low-scoring game.
• No. 5 Alabama at No. 14 LSU: They weigh Alabama’s injuries against LSU’s strong recent play and debate whether this turns into a shootout or a defensive battle.
• No. 23 Oregon at No. 12 Ohio State: Can Ohio State bounce back after its loss to USC? The crew talks about quarterback play, Oregon’s pass rush, Ohio State’s defense, and the pressure on the Buckeyes to win.
• No. 7 Texas at No. 18 Missouri: A tight spread sparks a debate about Texas’ offense, Arch Manning, Missouri’s potential, and whether the game goes over or under.
• No. 6 Kentucky at No. 13 Tennessee: The hosts break down Kentucky’s rise, Tennessee’s defense, and a matchup they expect to be close and hard to call.
• Vanderbilt at Mississippi State: Aaron hopes for a Bulldogs win, while Ryan picks Vanderbilt. The crew debates the low-scoring matchup and whether Mississippi State can find an answer without its injured star quarterback.
• No. 1 Miami at No. 11 Notre Dame: With Notre Dame’s playoff hopes on the line, the hosts debate Miami’s consistency, Notre Dame’s offense, and a tempting spread.
• No. 2 Georgia at No. 10 Ole Miss: The final featured game brings another playoff-stakes matchup—and sharply divided picks on the winner.

• 0:10 — Welcome and pick ’em rules
• 0:22 — No. 9 BYU vs. No. 3 Utah
• 2:28 — Arkansas at Auburn
• 4:01 — No. 5 Alabama at No. 14 LSU
• 6:08 — No. 23 Oregon at No. 12 Ohio State
• 10:20 — No. 7 Texas at No. 18 Missouri
• 13:40 — No. 6 Kentucky at No. 13 Tennessee
• 16:49 — Vanderbilt at Mississippi State
• 21:20 — No. 1 Miami at No. 11 Notre Dame
• 25:11 — No. 2 Georgia at No. 10 Ole Miss
• 28:32 — Playoff pressure and final thoughts
• 29:33 — Where to follow, comment, and share

Which pick are you most confident in—and where do you see an upset? Tell us what you think about BYU–Utah, Miami–Notre Dame, or Georgia–Ole Miss in the comments. And let us know: can Mississippi State get the win?Follow or subscribe, leave a rating and review, and share the episode with a college football fan. Find our short-form predictions on TikTok, Instagram, and YouTube, and join the game-day banter in the comments.#CollegeFootball #CFB #CollegeFootballPodcast #PickEm #GamePredictions #BYUvsUtah #AlabamaVsLSU #OregonVsOhioState #TexasVsMissouri #KentuckyVsTennessee #MiamiVsNotreDame #GeorgiaVsOleMiss #SEC #BigTen #RunAfterCast