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  • TWiV 1240: Clinical update with Dr. Daniel Griffin
    2025/08/02
    In his weekly clinical update, Dr. Griffin with Vincent Racaniello chat about the recent Salmonella typhimurim outbreak, the ousting of another CBER director, confirmation of a new CDC director and results of a recent pool about vaccine safety and trust before Dr. Griffin deep dives into recent statistics on RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, a new anti-influenza antibody that can be combined with neuraminidase inhibitors, whether or not the NB.1.8.1 should be included in the fall 2025 vaccines, the effectiveness of Sinopharm’s COVID-19 vaccine, where to find PEMGARDA, safety of the JN.1 updated vaccine, long COVID treatment center, where to go for answers to your long COVID questions, the prevalence of cardiac and pulmonary abnormalities found via medical imaging following COVID-19 and contacting your federal government representative to stop the assault on science and biomedical research. Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Outbreak of Salmonella Typhimurium Infections Linked to Commercially Distributed Raw Milk (CDC: MMWR)Top F.D.A. Official Resigns UnderPressure (NY Times)In a first, the Senate confirms a new CDC director (NPR)KFF Tracking Poll on Health Information and Trust: Vaccine Safety and Trust (KFF) Wastewater for measles (WasterWater Scan)Measles cases and outbreaks (CDC Rubeola)Weekly measles and rubella monitoring (Government of Canada)Measles vaccine recommendations from NYP (jpg)Measles (WHO)Get the FACTS about measles (NY State Department of Health) Measles (CDC Measles (Rubeola))Measles vaccine (CDC Measles (Rubeola)) Presumptive evidence of measles immunity (CDC) Contraindications and precautions to measles vaccination (CDC) Measles (CDC Measles (Rubeola))Adverse events associated with childhood vaccines: evidence bearing on causality (NLM)Measles Vaccination: Know the Facts(ISDA: Infectious Diseases Society of America)Deaths following vaccination: what does the evidence show (Vaccine)Influenza: Waste water scan for 11 pathogens (WastewaterSCan)US respiratory virus activity (CDC Respiratory Illnesses)Respiratory virus activity levels (CDC Respiratory Illnesses)Weekly surveillance report: clift notes (CDC FluView)Effects of baloxavir marboxil plus neuraminidase inhibitor versus neuraminidase inhibitor in high-risk patients hospitalized with severe influenza: a post hoc analysis of the Flagstone trial (OFID) FDA-CDC-DOD: 2025-2046 influenza vaccine composition (FDA)RSV: Waste water scan for 11 pathogens (WastewaterSCan)US respiratory virus activity (CDC Respiratory Illnesses)ENFLONSIA: novel drug approvals 2025 (FDA)RSV-Network (CDC Respiratory Syncytial virus Infection)Waste water scan for 11 pathogens (WastewaterSCan)COVID-19 deaths (CDC)Respiratory Illnesses Data Channel (CDC: Respiratory Illnesses)COVID-19 national and regional trends (CDC)COVID-19 variant tracker (CDC)SARS-CoV-2 genomes galore (Nextstrain)Antigenic and Virological Characteristics of SARS-CoV-2 Variant BA.3.2, XFG, and NB.1.8.1 (bioRxiV)Safety of JN.1-Updated mRNA COVID-19Vaccines (JAMA)Where to get pemgarda (Pemgarda) EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD)Infusion center (Prime Fusions) CDC Quarantine guidelines (CDC)NIH COVID-19 treatment guidelines (NIH)Drug interaction checker (University of Liverpool)Paxlovid (Pfizer) Infectious Disease Society guidelines for treatment and management (ID Society)Molnupiravir safety and efficacy (JMV)Convalescent plasma recommendation for immunocompromised (ID Society)What to do when sick with a respiratory virus (CDC)Managing healthcare staffing shortages (CDC)Steroids,dexamethasone at the right time (OFID) Anticoagulation guidelines (hematology.org)Daniel Griffin’s evidence based medical practices for long COVID (OFID)Long COVID hotline (Columbia : Columbia University Irving Medical Center)The answers: Long COVIDPrevalence of Persistent Cardiovascular and Pulmonary Abnormalities on PET/MRI and DECT Imaging in Long COVID Patients (Journal of Nuclear Medicine)Reaching out to US house representativeLetters read on TWiV 1240Dr. Griffin’s COVID treatment summary (pdf)Timestamps by Jolene Ramsey. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv Content in this podcast should not be construed as medical advice.
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    48 分
  • TWiV 1239: Aluminum and antibodies
    2025/07/27

    TWiV explains a cohort study of over one million Danish children which shows no evidence supporting an increased risk for autoimmune, atopic or allergic, or neurodevelopmental disorders associated with early childhood exposure to vaccines with aluminum-base adjuvants, and a study of antibodies induced by mRNA-1273 and NVX-CoV2373 COVID-19 vaccines which show that polyclonal antibodies against a single site on the
    spike N-terminal domain show immunodominance, high diversity, and limited cross-reactivity, indicating the need to direct antibody responses away from this site.

    Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker

    Subscribe (free): Apple Podcasts, RSS, email

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    Links for this episode
    • Support science education at MicrobeTV
    • No chronic effects of aluminum-based adjuvants in vaccines (Ann Int Med)
    • Aluminum in vaccines (CHOP)
    • Structural serology of antibody responses to COVID vaccines (Cell Rep)
    • Letters read on TWiV 1239
    • Timestamps by Jolene Ramsey. Thanks!
    Weekly Picks

    Brianne – MHC Class I Antigen Presentation Video
    Alan – We Become What We Behold
    Vincent – New Injectable Recommended by Europe for HIV Prevention

    Intro music is by Ronald Jenkees

    Send your virology questions and comments to twiv@microbe.tv

    Content in this podcast should not be construed as medical advice.

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    1 時間 51 分
  • TWiV 1238: Clinical update with Dr. Daniel Griffin
    2025/07/26
    In his weekly clinical update, Dr. Griffin with Vincent Racaniello chat about how flies transmit H5N1 to humans via their feet and milk, the recent pertussis oubreak and measles epidemic before Dr. Griffin discusses monoclonal antibody therapy can enrich for RSV variants before deep diving into recent statistics on RSV, influenza and SARS-CoV-2 infections the Wasterwater Scan dashboard, whether or not the NB.1.8.1 should be included in the fall 2025 vaccines, the effectiveness of Sinopharm’s COVID-19 vaccine, where to find PEMGARDA, provides information for Columbia University Irving Medical Center’s long COVID treatment center, where to go for answers to your long COVID questions, how mast cell activation can enhance long COVID and contacting your federal government representative to stop the assault on science and biomedical research. Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Flies, ‘milk snatching’ among H5N1 transmission contributors in dairy cattle(CIDRAP)H5N1 virus invades the mammary glands of dairy cattle through “mouth-to-teat” transmission (NSR: National Science Review)Mississippi warns of steep increase in pertussis cases (CIDRAP)MSDH Issues Pertussis Alert (Mississippi State Department of Health) Wastewater for measles (WasterWater Scan)Measles cases and outbreaks (CDC Rubeola)Weekly measles and rubella monitoring (Government of Canada)Measles vaccine recommendations from NYP (jpg)Measles (WHO)Get the FACTS about measles (NY State Department of Health) Measles (CDC Measles (Rubeola))Measles vaccine (CDC Measles (Rubeola)) Presumptive evidence of measles immunity (CDC) Contraindications and precautions to measles vaccination (CDC) Measles (CDC Measles (Rubeola))Adverse events associated with childhood vaccines: evidence bearing on causality (NLM)Measles Vaccination: Know the Facts (ISDA: Infectious Diseases Society of America)Deaths following vaccination: what does the evidence show (Vaccine)Influenza: Waste water scan for 11 pathogens (WastewaterSCan)US respiratory virus activity (CDC Respiratory Illnesses)Respiratory virus activity levels (CDC Respiratory Illnesses)Weekly surveillance report: clift notes (CDC FluView) FDA-CDC-DOD: 2025-2046 influenza vaccine composition (FDA)RSV: Waste water scan for 11 pathogens (WastewaterSCan)US respiratory virus activity (CDC Respiratory Illnesses)ENFLONSIA: novel drug approvals 2025 (FDA)RSV-Network (CDC Respiratory Syncytial virus Infection)Respiratory Syncytial virus Strain Evolution and Mutations in Western Australia in the Context of Nirsevimab Prophylaxis (OFID)Waste water scan for 11 pathogens (WastewaterSCan)COVID-19 deaths (CDC)Respiratory Illnesses Data Channel (CDC: Respiratory Illnesses)COVID-19 national and regional trends (CDC)COVID-19 variant tracker (CDC)SARS-CoV-2 genomes galore (Nextstrain)Antigenic and Virological Characteristics of SARS-CoV-2 Variant BA.3.2, XFG, and NB.1.8.1 (biRxiV)Real-world Evaluation of the Effectiveness of Sinopharm COVID-19 Vaccine Against Symptomatic COVID-19 in an Omicron-Dominant Setting in Mozambique (CID)Where to get pemgarda (Pemgarda) EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD)Infusion center (Prime Fusions) CDC Quarantine guidelines (CDC)NIH COVID-19 treatment guidelines (NIH)Drug interaction checker (University of Liverpool)Paxlovid (Pfizer) Infectious Disease Society guidelines for treatment and management (ID Society)Molnupiravir safety and efficacy (JMV)Convalescent plasma recommendation for immunocompromised (ID Society)What to do when sick with a respiratory virus (CDC)Managing healthcare staffing shortages (CDC)Steroids, dexamethasone at the right time (OFID) Anticoagulation guidelines (hematology.org)Daniel Griffin’s evidence based medical practices for long COVID (OFID)Long COVID hotline (Columbia : Columbia University Irving Medical Center)The answers: Long COVID Mast cell activation symptoms are prevalent in Long-COVID (International Journal of Infectious Diseases)Using the Right Criteria for MCAS (Current Allergy and Asthma Reports)Utility of glucagon-like-peptide-1-receptor agonists in mast cell activation syndrome (The American Journal of the Medical Sciences)Reaching out to US house representativeLetters read on TWiV 1238Dr. Griffin’s COVID treatment summary (pdf)Timestamps by Jolene Ramsey. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv Content in this podcast should not be construed as medical advice.
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    45 分
  • TWiV 1237: Hepatitis C and persistence with Charlie Rice
    2025/07/20

    From the 2025 annual meeting of the American Society for Virology, Charlie Rice, 2020 Nobel Laureate in Physiology or Medicine, talks with Vincent and Kathy about his career and the scientific difficulties he and his laboratory encountered in their attempts to achieve replication of hepatitis C virus in cells in culture.

    Hosts: Vincent Racaniello and Kathy Spindler

    Guest: Charlie Rice

    Subscribe (free): Apple Podcasts, RSS, email

    Become a patron of TWiV!

    Links for this episode
    • Support science education at MicrobeTV
    • 2020 Nobel Prize (Nobel Prizes)
    • Hepatitis C human challenge study (Lancet Gastro Hepatol)
    • Rat hepacivirus mouse model for hepatitis C (Hepatol)
    • Replication of hepatitis C virus in cells in culture (Science)
    • Lessons from domestication of HCV (Curr Opin Virol)

    Intro music is by Ronald Jenkees

    Send your virology questions and comments to twiv@microbe.tv

    Content in this podcast should not be construed as medical advice.

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    1 時間 6 分
  • TWiV 1236: Clinical update with Dr. Daniel Griffin
    2025/07/19
    In his weekly clinical update, Dr. Griffin with Vincent Racaniello have a morning chat about the measles epidemic and H5N1 in cows before Dr. Griffin discusses how vaccination associates with reduced dementia risk before deep diving into recent statistics on measles epidemic, RSV, influenza and SARS-CoV-2 infections the Wasterwater Scan dashboard, a potential new influenza antiviral drug, whether or not the NB.1.8.1 variant should be included in the fall 2025 vaccines, immunization recommendations for COVID-19 vaccines, where to find PEMGARDA, provides information for Columbia University Irving Medical Center’s long COVID treatment center, where to go for answers to your long COVID questions, associaton of remesdivir administration and long-term sequelae and contacting your federal government representative to stop the assault on science and biomedical research. Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Wastewater for measles (WasterWater Scan)Measles cases and outbreaks (CDC Rubeola)Weekly measles and rubella monitoring (Government of Canada)Measles (WHO)Get the FACTS about measles (NY State Department of Health) Measles (CDC Measles (Rubeola))Measles vaccine (CDC Measles (Rubeola)) Presumptive evidence of measles immunity (CDC) Contraindications and precautions to measles vaccination (CDC) Measles (CDC Measles (Rubeola))Adverse events associated with childhood vaccines: evidence bearing on causality (NLM)Measles Vaccination: Know the Facts (ISDA: Infectious Diseases Society of America)Deaths following vaccination: what does the evidence show (Vaccine)Measles vaccine recommendations from NYP (jpg)The impact of highly pathogenic avian influenza H5N1 virus infection on dairy cows (Nature)Avian flu exacts heavy financial toll on dairy industry, report says(CIDRAP)Inherited IFNAR1 deficiency in otherwise healthy patients with adverse reaction to measles and yellow fever live vaccines (Journal of Experimental Medicine)Influenza: Waste water scan for 11 pathogens (WastewaterSCan)US respiratory virus activity (CDC Respiratory Illnesses)Respiratory virus activity levels (CDC Respiratory Illnesses)Weekly surveillance report: clift notes (CDC FluView) FDA-CDC-DOD: 2025-2046 influenza vaccine composition (FDA)RSV: Waste water scan for 11 pathogens (WastewaterSCan)US respiratory virus activity (CDC Respiratory Illnesses)ENFLONSIA: novel drug approvals 2025 (FDA)RSV-Network (CDC Respiratory Syncytial virus Infection)Systematic review and expert consensus on the use of long-acting monoclonal antibodies for prevention of respiratory syncytial virus disease: ARMADA (Advancing RSV Management And Disease Awareness) Taskforce (OFID)Waste water scan for 11 pathogens (WastewaterSCan)COVID-19 deaths (CDC)COVID cases likely rising in half of states, CDC estimates(CBS News)Estimated COVID-19 Periodicity and Correlation with SARS-CoV-2 Spike Protein S1 Antigenic Diversity, United States (Emerging Infectious Diseases)Respiratory Illnesses Data Channel (CDC: Respiratory Illnesses)COVID-19 national and regional trends (CDC)COVID-19 variant tracker (CDC)Estimated COVID-19 Periodicity and Correlation with SARS-CoV-2 Spike Protein S1 Antigenic Diversity, United States (Emerging Infectious Diseases)SARS-CoV-2 genomes galore (Nextstrain)Antigenic and Virological Characteristics of SARS-CoV-2 Variant BA.3.2, XFG, and NB.1.8.1 (biRxiV)This CDC Resignation Should Scare You (Substack: Beyond the Noise)ACIP: COVID-19–Associated Hospitalizations — COVID-NET, April 2025 Update (CDC: National Center for Immunization and Respiratory Diseases))Where to get pemgarda (Pemgarda) EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD)Infusion center (Prime Fusions) CDC Quarantine guidelines (CDC)NIH COVID-19 treatment guidelines (NIH)Drug treatments for mild or moderate covid-19: systematic review and network meta-analysis (BMJ)Drug interaction checker (University of Liverpool)Paxlovid (Pfizer) Infectious Disease Society guidelines for treatment and management (ID Society)Extended nirmatrelvir–ritonavir treatment durations for immunocompromised patients with COVID-19 (EPIC-IC) (LANCET: Infectious Diseases)Molnupiravir safety and efficacy (JMV)Convalescent plasma recommendation for immunocompromised (ID Society)What to do when sick with a respiratory virus (CDC)Managing healthcare staffing shortages (CDC)Steroids, dexamethasone at the right time (OFID) Anticoagulation guidelines (hematology.org)Daniel Griffin’s evidence based medical practices for long COVID (OFID)Long COVID hotline (Columbia : Columbia University Irving Medical Center)The answers: Long COVIDInvivyd and Leading Researchers Form SPEAR (Spike Protein Elimination and Recovery) Study Group to Assess the Effects of Monoclonal Antibody Therapy for Long COVID and COVID-19 Post-Vaccination Syndrome (INVIVYD)Reaching out to...
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    49 分
  • TWiV 1235: Two sexy to eradicate
    2025/07/13

    David Barton, Brian Kemp, and Olve Peersen join TWiV to discuss RNA recombination among enteroviruses and its role in foiling poliovirus eradication.

    Hosts: Vincent Racaniello, Alan Dove, and Rich Condit

    Guests: David Barton, Brian Kempf, and Olve Peersen

    Subscribe (free): Apple Podcasts, RSS, email

    Become a patron of TWiV!

    Links for this episode
    • Support science education at MicrobeTV
    • Enterovirus C recombination groups (J Virol)
    • Poliovirus polymerase L420 facilitates RNA recombination (J Virol)
    • Picornavirus RNA recombination counteracts error catastrophe (J Virol)
    • Extended primer grip and picornavirus RNA recombination (J Virol)
    • Timestamps by Jolene Ramsey. Thanks!

    Intro music is by Ronald Jenkees

    Send your virology questions and comments to twiv@microbe.tv

    Content in this podcast should not be construed as medical advice.

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    1 時間 36 分
  • TWiV 1234: Clinical update with Dr. Daniel Griffin
    2025/07/12
    In his weekly clinical update, Dr. Griffin with Vincent Racaniello note that history is being rewritten for justification of changes in COVID vaccine guidelines including myocarditis incidence and the Great Barrington Declaration ignoring presentations at the April 2025 ACIP, the response by the medical community to these changed guidelines, before Dr. Griffin discusses how vaccination associates with reduced dementia risk before deep diving into recent statistics on measles epidemic, RSV, influenza and SARS-CoV-2 infections the Wasterwater Scan dashboard, a potential new influenza antiviral durg, whether or not the NB.1.8.1 should be included in the fall 2025 vaccines, immunization recommendations for COVID-19 vaccines, where to find PEMGARDA, provides information for Columbia University Irving Medical Center’s long COVID treatment center, where to go for answers to your long COVID questions, associaton of remesdivir administration and long-term sequelae and contacting your federal government representative to stop the assault on science and biomedical research. Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode FDA to look again at myocarditis risk from mRNA-based COVID-19 jabs in young men (FirstWord PHARMA) Great Barrington Declaration (Great Barrington Declaration) Debunking Herd Immunity: A Review of We Want Them Infected (Global Autoimmune InstituteScientific consensus on the COVID-19 pandemic (LANCET)John Snow, memo vaccines-plus strategy (John Snow Memorandum)This CDC Resignation Should Scare You (Substack: Beyond the Noise)COVID-19–Associated Hospitalizations — COVID-NET, April 2025 Update (CDC: National Center for Immunization and Respiratory Diseases)Leading Medical Professional Societies, Patient Sue HHS, Robert F. Kennedy, Jr. for Unlawful, Unilateral Vaccine Changes (ACP: American College of Physicians)Medical groups sue HHS, Kennedy over COVID vaccine policy changes(CIDRAP)Lower risk of dementia with AS01-adjuvanted vaccination against shingles and respiratory syncytial virus infections (Vaccines)Influenza vaccination reduces dementia risk (Ageing Research Reviews) Wastewater for measles (WasterWater Scan)Measles cases and outbreaks (CDC Rubeola)New Mexico announces measles outbreak in a county detention facility(AP News)Weekly measles and rubella monitoring (Government of Canada)Measles vaccine recommendations from NYP (jpg)Measles (WHO)Get the FACTS about measles (NY State Department of Health) Measles (CDC Measles (Rubeola))Measles vaccine (CDC Measles (Rubeola)) Presumptive evidence of measles immunity (CDC) Contraindications and precautions to measles vaccination (CDC) Measles (CDC Measles (Rubeola))Adverse events associated with childhood vaccines: evidence bearing on causality (NLM)Measles Vaccination: Know the Facts(ISDA: Infectious Diseases Society of America)Deaths following vaccination: what does the evidence show (Vaccine)Influenza: Waste water scan for 11 pathogens (WastewaterSCan)US respiratory virus activity (CDC Respiratory Illnesses)Respiratory virus activity levels (CDC Respiratory Illnesses)Weekly surveillance report: clift notes (CDC FluView)Cidara Therapeutics Announces Positive Topline Results from its Phase 2b NAVIGATE Trial Evaluating CD388, a Non-Vaccine Preventative of Seasonal Influenza (CIDARA Therapeutics)Experimental flu drug may protect better than flu vaccines(CIDRAP) FDA-CDC-DOD: 2025-2046 influenza vaccine composition (FDA)RSV: Waste water scan for 11 pathogens (WastewaterSCan)US respiratory virus activity (CDC Respiratory Illnesses)RSV-Network (CDC Respiratory Syncytial virus Infection) Readmission Following Respiratory Syncytial Virus Hospitalization among Children <5 Years of Age (Journal of Pediatric Infectious Diseases Society)Waste water scan for 11 pathogens (WastewaterSCan)COVID-19 deaths (CDC)COVID-19 national and regional trends (CDC)COVID-19 variant tracker (CDC)SARS-CoV-2 genomes galore (Nextstrain)Antigenic and Virological Characteristics of SARS-CoV-2 Variant BA.3.2, XFG, and NB.1.8.1 (biRxiV)Where to get pemgarda (Pemgarda) EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD)Infusion center (Prime Fusions) CDC Quarantine guidelines (CDC)NIH COVID-19 treatment guidelines (NIH)Drug interaction checker (University of Liverpool) Infectious Disease Society guidelines for treatment and management (ID Society)Molnupiravir safety and efficacy (JMV)Convalescent plasma recommendation for immunocompromised (ID Society)What to do when sick with a respiratory virus (CDC)Managing healthcare staffing shortages (CDC)Steroids,dexamethasone at the right time (OFID) Anticoagulation guidelines (hematology.org)Daniel Griffin’s evidence based medical practices for long COVID (OFID)Long COVID hotline (Columbia : Columbia University Irving Medical Center)The answers: Long COVIDAssociation of SARS-CoV-2 With ...
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    55 分
  • TWiV 1233: Long COVID and big bats
    2025/07/06

    TWiV covers FDA Director overriding scientists on COVID shots, NIH funded science must now be free to read instantly, Trump cuts subscriptions to Springer Nature journals, UK and Gates make up for US money withdrawn from GAVI, US defunding USAID could lead to 14 million deaths by 2030, then reviews research on how host IL1 genetics regulates Epstein-Barr virus reactivation and long COVID, and enhanced antiviral capacity of bat innate immunity.

    Hosts: Vincent Racaniello, Alan Dove, and Rich Condit

    Subscribe (free): Apple Podcasts, RSS, email

    Become a patron of TWiV!

    Links for this episode
    • Support science education at MicrobeTV
    • FDA official overrides scientists on COVID shots (NYTimes)
    • NIH funded science must be immediately open access (Nature)
    • Trump cuts journal subscriptions for NIH (Science)
    • Donors make up GAVI US shortfall (Reuters)
    • USAID defunding will lead to 14 million deaths (CIDRAP)
    • SARS-CoV-2, IL1, Epstein-Barr virus and long COVID (Cell Rep)
    • Bat innate immunity (Nat Comm)
    • Letters read on TWiV 1233
    • Timestamps by Jolene Ramsey. Thanks!
    Weekly Picks

    Rich – Unraveling Mendel’s final mysteries: A genomic retelling of pea genetics (Thanks, Kathy!) (Original article)
    Alan – Winners of Nature’s 2025 “Scientist at Work” photo competition
    Vincent – Signs of AI-generated text found in 14% of biomedical abstracts last year

    Intro music is by Ronald Jenkees

    Send your virology questions and comments to twiv@microbe.tv

    Content in this podcast should not be construed as medical advice.

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    1 時間 51 分