How is adjuvant treatment for ER-positive, HER2-negative breast cancer changing?

At This Moment in Medicine, Dr. Akshjot Puri examines key data from OPTIMA, lidERA, NATALEE, and monarchE—and what these trials could mean for chemotherapy de-escalation, endocrine therapy, ovarian suppression, and CDK4/6 inhibitor use.

From using Prosigna to identify patients who may be able to avoid chemotherapy to the emerging role of oral SERDs, the presentation highlights how treatment is becoming increasingly individualized based on risk, biology, and patient needs.

Topics discussed:

• OPTIMA and Prosigna-guided chemotherapy de-escalation
• Chemotherapy benefit in premenopausal and postmenopausal patients
• The role of ovarian function suppression
• Oncotype DX, MammaPrint, and Prosigna
• lidERA and giredestrant in the adjuvant setting
• NATALEE vs. monarchE
• Ribociclib and abemaciclib in early-stage disease
• ctDNA and emerging biomarkers for treatment selection
• Individualizing therapy for intermediate- and high-risk patients

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#ThisMomentInMedicine #AkshjotPuri #BreastCancer #ERPositive #HER2Negative #OPTIMA #Prosigna #Giredestrant #NATALEE #MonarchE #BreastOncology #CommunityHealthMedia

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