How should we approach first-line treatment as the HER2-positive metastatic breast cancer landscape rapidly evolves?

At This Moment in Medicine, hosted by Community Health Media, Dr. Mothaffar Rimawi examines how new data are reshaping a treatment landscape long defined by the CLEOPATRA regimen.

From DESTINY-Breast09 to PATINA and HER2CLIMB-05, Dr. Rimawi explores emerging strategies for deeper HER2 and ER pathway inhibition, the role of T-DXd, and how clinicians might individualize treatment based on disease biology, burden, toxicity, and patient preference.

Topics discussed:

• The evolution of first-line HER2-positive metastatic breast cancer treatment
• CLEOPATRA and the foundation of modern HER2-directed therapy
• PATINA and the addition of palbociclib in HR+/HER2+ disease
• DESTINY-Breast09 and T-DXd plus pertuzumab
• Depth and duration of response with T-DXd
• HER2CLIMB-05 and tucatinib maintenance
• ILD, transaminitis, and other treatment-related toxicities
• Patient-reported outcomes and quality of life
• Selecting treatment based on ER status, CNS disease, disease burden, and molecular profile
• T-DXd duration and the possibility of induction-maintenance strategies
• How PATINA and HER2CLIMB-05 could inform maintenance therapy

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The presentation concludes with a panel discussion addressing a critical question for the field: With several highly effective strategies now available, how do we choose the right first-line approach for the right patient?

▶️ Watch more from This Moment in Medicine and subscribe to Community Health Media for expert conversations on the latest advances shaping cancer care.

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#ThisMomentInMedicine #MothaffarRimawi #HER2Positive #MetastaticBreastCancer #DESTINYBreast09 #TDXd #PATINA #HER2CLIMB05 #BreastOncology #MedicalOncology #CommunityHealthMedia

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