The history of the serotonin hypothesis of depression
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The history of the serotonin hypothesis of depression
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We can define psychiatric disorders as diseases of the brain whose precise cause we do not know. This is also the case with depression. For a long time, a serotonin deficiency hypothesis was assumed, which was later modified into a monoamine imbalance hypothesis. As is so often the case with psychiatric illnesses, the starting point was an accidental finding that a medication worked - in this case, a drug used to treat tuberculosis. Because this debate remains relevant today for understanding depression and its treatment, we present its history from its beginnings in the 1950s. How did the serotonin hypothesis of depression come about, what were the main findings, and who were the key players? What truth lies within it, or is it entirely off the mark?