Every year, millions of people adjust their clocks, but what does this one-hour shift really mean for our bodies, minds, and daily lives? In this episode, Dr. Manfred Stapff offers a grounded, science-based look at the impact of daylight saving time and why it continues to spark debate.

Dr. Manfred traces the origins of daylight saving time back to World War I and explains how its purpose has evolved in modern society. He explores what current research reveals about its effects on energy use, productivity, and health drawing from real-world data on more than 170,000 patients.

Beyond data, Dr. Manfred considers how light exposure shapes our mood, vitamin D levels, and overall sense of balance.

See how science transforms the way we think about time. Tune in the full episode of The Hidden Science Behind Time Change: Does It Really Matter?

Dr. Manfred Stapff is an entrepreneurial biotech and pharmaceutical expert with deep expertise in real-world evidence and clinical research. As a seasoned leader, he brings decades of experience across all phases of drug development, from opportunity assessment to product launch. His work bridges science and strategy, ensuring medical decisions are grounded in accurate, meaningful data. Dr. Stapff is also an author, committed to promoting evidence-based thinking in medicine. His insights challenge misinformation and advocate for scientific integrity in today's data-driven world.

Connect with Dr. Manfred Stapff, MD:

LinkedIn: https://www.linkedin.com/in/manfredstapff/

Can a common pain reliever hold hidden risks for unborn children? In this episode, Dr. Manfred Stapff tackles one of medicine's most debated questions, whether acetaminophen use during pregnancy could influence autism risk.

Dr. Manfred explores the rise in autism diagnoses, explaining how shifting definitions and improved awareness shape the numbers. He then analyzes key studies, from the Boston Birth Cohort to Sweden's national registry, revealing why research outcomes differ.

While data show mixed findings, acetaminophen remains one of the safest treatments for pain and fever in pregnancy when used responsibly. Sometimes, the greater risk lies not in the medicine itself but in what happens when we avoid it.

Tune in for a powerful conversation that moves beyond fear toward informed understanding. Uncovering the Truth: Acetaminophen Use in Pregnancy and Autism Risk.

Dr. Manfred Stapff is an entrepreneurial biotech and pharmaceutical expert with deep expertise in real-world evidence and clinical research. As a seasoned leader, he brings decades of experience across all phases of drug development, from opportunity assessment to product launch. His work bridges science and strategy, ensuring medical decisions are grounded in accurate, meaningful data. Dr. Stapff is also an author, committed to promoting evidence-based thinking in medicine. His insights challenge misinformation and advocate for scientific integrity in today's data-driven world.

Connect with Dr. Manfred Stapff, MD:

LinkedIn: https://www.linkedin.com/in/manfredstapff/

Vaccines have saved millions of lives. Yet they remain one of society's fiercest dividing lines. In this episode, Dr. Manfred Stapff confronts why vaccines spark both trust and resistance, examining the science, ethics, and politics that fuel the debate.

He explains why the evidence is clear: vaccines prevent severe illness and save lives. Mild side effects signal an active immune system, while serious reactions are extremely rare compared to the dangers of the diseases themselves. Still, misinformation, poor communication, and political agendas distort the conversation and erode public trust.

Vaccination is more than personal protection. It's a commitment to community health. Mandates should be rare and carefully justified, but stresses that public understanding is essential for any policy to succeed.

Tune in for this episode that helps audiences think more critically about the role of vaccines in shaping a healthier society. Vaccines and Society: Balancing Science, Ethics, and Politics.

Dr. Manfred Stapff is an entrepreneurial biotech and pharmaceutical expert with deep expertise in real-world evidence and clinical research. As a seasoned leader, he brings decades of experience across all phases of drug development, from opportunity assessment to product launch. His work bridges science and strategy, ensuring medical decisions are grounded in accurate, meaningful data. Dr. Stapff is also an author, committed to promoting evidence-based thinking in medicine. His insights challenge misinformation and advocate for scientific integrity in today's data-driven world.

Connect with Dr. Manfred Stapff, MD:

LinkedIn: https://www.linkedin.com/in/manfredstapff/

Obesity affects nearly 40% of Americans, making it one of today's most urgent health crises. In this episode, Dr. Manfred Stapff cuts through confusion and misinformation to show what the data truly reveal about nutrition and obesity.

Dr. Manfred explains why excess calories not burned through daily activity drive weight gain, and how obesity fuels risks for diabetes, cancer, and premature death. Drawing on major studies, he exposes the flaws in self-reported nutrition research while offering simple, evidence-based rules: keep calories around 2,000, eat more protein, cut back on carbs and sugar, and skip late-night snacks.

The message is clear. Obesity is about survival. The science shows that informed choices can cut risks and extend life.

Hear how real evidence, not online trends, can guide healthier habits and change the future of public health. Tune into the full episode of Nutrition and Obesity.

Dr. Manfred Stapff is an entrepreneurial biotech and pharmaceutical expert with deep expertise in real-world evidence and clinical research. As a seasoned leader, he brings decades of experience across all phases of drug development, from opportunity assessment to product launch. His work bridges science and strategy, ensuring medical decisions are grounded in accurate, meaningful data. Dr. Stapff is also an author, committed to promoting evidence-based thinking in medicine. His insights challenge misinformation and advocate for scientific integrity in today's data-driven world.

Connect with Dr. Manfred Stapff, MD:

LinkedIn: https://www.linkedin.com/in/manfredstapff/

Marijuana smoking and tattoos are personal choices. What does the evidence really say about their health risks? In this episode, Dr. Manfred Stapff cuts through the myths, and delivers the science-backed truth about weed, ink, and your well-being.

Using a major California study, he explains why cannabis users face a threefold higher risk of oral cancer and why the real story lies in understanding absolute risk and the "number needed to harm."

Dr. Manfred then turns to tattoos, uncovering a Swedish study that hints at a troubling link to lymphoma, and revealing how hidden metals and chemicals may linger in the body… Forever.

See how evidence—not emotion—can shape better choices. Tune in to the full episode of Data, Decisions, and Danger: What Evidence Reveals About Tattoos and Cannabis.

Dr. Manfred Stapff is an entrepreneurial biotech and pharmaceutical expert with deep expertise in real-world evidence and clinical research. As a seasoned leader, he brings decades of experience across all phases of drug development—from opportunity assessment to product launch. His work bridges science and strategy, ensuring medical decisions are grounded in accurate, meaningful data. Dr. Stapff is also an author, committed to promoting evidence-based thinking in medicine. His insights challenge misinformation and advocate for scientific integrity in today’s data-driven world.

Connect with Dr. Manfred Stapff, MD:

LinkedIn: https://www.linkedin.com/in/manfredstapff/

Website: https://candid-advisory

Healthcare costs are rising, but are the reasons valid? In this episode, Dr. Manfred Stapff examines UnitedHealthcare's proposed 18% rate hike and asks: where's the evidence?

Using authoritative data from CMS and PricewaterhouseCoopers, Dr. Manfred reveals how this price increase sharply diverges from national healthcare cost trends. He confronts the growing tension between record-breaking profits and patient affordability, and challenges the flawed logic of treating healthcare as a free-market commodity.

With clarity and depth, this episode equips listeners to question inflated costs, analyze systemic inefficiencies, and rethink the incentives behind our healthcare decisions.

Gain sharper insight into how science—not speculation—should shape the future of healthcare. Tune in to the episode: Beyond the 18% Hike: What's Broken in the Health Care System of UnitedHealthcare.

Dr. Manfred Stapff is an entrepreneurial biotech and pharmaceutical expert with deep expertise in real-world evidence and clinical research. As a seasoned leader, he brings decades of experience across all phases of drug development—from opportunity assessment to product launch. His work bridges science and strategy, ensuring medical decisions are grounded in accurate, meaningful data. Dr. Stapff is also an author, committed to promoting evidence-based thinking in medicine. His insights challenge misinformation and advocate for scientific integrity in today's data-driven world.

Connect with Dr. Manfred Stapff, MD:

LinkedIn: https://www.linkedin.com/in/manfredstapff/

Website: https://candid-advisory.com/

Vaccines and autism spark fierce debate, where science meets emotion. This episode offers sharp, confident clarity.

Dr. Manfred Stapff cuts through decades of controversy on breaking down the supposed link between the measles vaccine and autism. With firm, science-backed insights, he shows how rigorous research, not headlines, has shaped what we know today.

He highlights the measles vaccine's stunning success, the science behind immunity, and why fears sparked by the flawed Wakefield paper still linger. You'll learn how real evidence is built and why emotions, though natural, can cloud judgment when weighed against overwhelming data.

For anyone tired of misinformation and ready for honest answers, this episode is essential. Tune into the full episode: Uncovering the Correlation Between Measles, Vaccines, and Autism.

Dr. Manfred Stapff is an entrepreneurial biotech and pharmaceutical expert with deep expertise in real-world evidence and clinical research. As a seasoned leader, he brings decades of experience across all phases of drug development—from opportunity assessment to product launch. His work bridges science and strategy, ensuring medical decisions are grounded in accurate, meaningful data. Dr. Stapff is also an author, committed to promoting evidence-based thinking in medicine. His insights challenge misinformation and advocate for scientific integrity in today's data-driven world.

Connect with Dr. Manfred Stapff, MD:

LinkedIn: https://www.linkedin.com/in/manfredstapff/

Website: https://candid-advisory.com/

In a world overwhelmed by conflicting headlines, viral rumors, and half-baked statistics, how can one tell what's real?

In this episode, Dr. Manfred Stapff breaks down the science behind real-world evidence (RWE) and reveals how it can be used to separate fact from fiction in public health, media, and policy conversations.

He carefully guides audiences through real examples, like the GLP-1 drug studies and COVID mask debates, to show how well-intended data can become misleading when stripped of scientific rigor or proper communication.

Whether you're a policymaker, academic, healthcare provider, or simply a curious citizen, this discussion will challenge your assumptions and equip you with tools to think critically about the information you receive.

Ready to get smart about the science behind the headlines? Tune in now to our pilot episode and start thinking clearly about what’s true, what’s noise, and what really matters.

Tune into the full episode of Facts, Fear, and Future: Exposing Misinformation with Real-World Evidence

Dr. Manfred Stapff is an entrepreneurial biotech and pharmaceutical expert with deep expertise in real-world evidence and clinical research. As a seasoned leader, he brings decades of experience across all phases of drug development—from opportunity assessment to product launch. His work bridges science and strategy, ensuring medical decisions are grounded in accurate, meaningful data. Dr. Stapff is also an author, committed to promoting evidence-based thinking in medicine. His insights challenge misinformation and advocate for scientific integrity in today’s data-driven world.

Connect with Dr. Manfred Stapff, MD:

LinkedIn: https://www.linkedin.com/in/manfredstapff/

Website: https://candid-advisory.com/