『The Modern Midlife Collective』のカバーアート

The Modern Midlife Collective

The Modern Midlife Collective

著者： Dr. Ade Akindipe DNP MBA APRN FNP-C and Dr. Jillian Woodruff MD FACOG NCMP
無料で聴く

【Amazonプライム会員限定】今ならプレミアムプランが4か月 月額99円。

10月19日まで。※適用条件あり
Welcome to The Modern Midlife Collective—where midlife isn’t a crisis, it’s a rebirth. Hosted by Dr. Ade Akindipe, DNP, and Dr. Jillian Woodruff, MD, this is the podcast for women ready to unapologetically own their power, thrive through the ups and downs of hormones, weight, and self-care, and show the world that thriving at 40 and beyond isn’t just possible—it’s your birthright. Biweekly, we bring you science-backed insights on hormones, menopause, longevity, and sexual health—real tools to empower women in midlife and beyond. With a fearless blend of functional medicine, real-life wisdom, and no-nonsense empowerment, we’re here to challenge the norms, break through the barriers, and help you step into a life of vitality, confidence, and unstoppable strength. Ready to rise? Let’s do this.© 2026 Dr. Ade Akindipe, DNP, MBA, APRN, FNP-C and Dr. Jillian Woodruff, MD, FACOG, NCMP 衛生・健康的な生活 身体的病い・疾患
エピソード
  • Episode 42: “Brain Fog + Hair Loss? Don’t Blame Menopause Yet: Your Iron May Not Be as ‘Normal’ as You Think”

    Episode 42: “Brain Fog + Hair Loss? Don’t Blame Menopause Yet: Your Iron May Not Be as ‘Normal’ as You Think”
    2026/09/30

    Brain fog? Hair shedding? Restless legs? Before you automatically blame menopause, it may be time to take another look at your iron.


    New 2026 guidelines are changing how iron deficiency is diagnosed, and yes, you can have iron deficiency even when you're not anemic.


    In Episode 42 of The Modern Midlife Collective, Dr. Jillian Woodruff and Dr. Ade Akindipe unpack the newly released American Society of Hematology guidelines on diagnosing iron deficiency.


    We're going beyond the symptom everyone already knows, fatigue, and talking about the signs midlife women may not associate with iron:

    • Brain fog and difficulty concentrating
    • Hair and nail changes
    • Restless legs
    • Poor exercise tolerance
    • Mood changes
    • Pica and ice chewing
    • Heavy menstrual bleeding during perimenopause


    You'll also learn why a “normal” CBC doesn't automatically rule out iron deficiency, what ferritin tells us, why laboratory reference ranges aren't always the same as clinical decision thresholds, and why finding low iron should prompt another important question:


    Why is the iron low in the first place?


    In this episode:

    • Iron deficiency vs. iron-deficiency anemia
    • The new 2026 ferritin diagnostic thresholds
    • Why brain fog isn't automatically menopause
    • The complicated connection between iron and hair loss
    • Heavy periods and iron depletion during perimenopause
    • Why postmenopausal iron-deficiency anemia needs further evaluation
    • Ferritin, CBC and transferrin saturation
    • Why you shouldn't automatically start iron supplements
    • Three questions to take to your next medical appointment


    Your three questions:

    1. What was my actual ferritin?
    2. Could I have iron deficiency even though I'm not anemic?
    3. If my iron is low, why is it low?


    Resources

    American Society of Hematology: 2026 Guidelines on Diagnosis of Iron Deficiency
    CMAJ: Diagnosis and Management of Iron Deficiency in Females
    JAMA: Iron Deficiency in Adults: A Review
    American Gastroenterological Association: GI Evaluation of Iron Deficiency Anemia
    American Academy of Sleep Medicine: Treatment of Restless Legs Syndrome Guideline


    The Modern Midlife Collective
    Because thriving at 40 and beyond isn't just possible. It's your birthright.
    続きを読む 一部表示
    45 分
  • Episode 41: The Estrogen Lie, Revisited

    Episode 41: The Estrogen Lie, Revisited
    2026/09/16
    Back in Episode 20, Dr. Jill and Dr. Ade covered the FDA's decision to walk back twenty years of black box warnings on hormone therapy. Since then, hormone therapy has become a genuine moment on social media, and not always an accurate one. In this quick-turnaround update, they separate what the newest research actually shows from what the internet is claiming, including a new Stanford study linking estrogen-only therapy to lower Alzheimer's markers, why that finding does not extend to combined therapy, and what the twenty-year-old dementia data really pins the risk on.Segment GuideCold open: What changed since Episode 20, and why this update existsThe quick WHI recap, done right: relative risk versus absolute risk, and the age-stratified "timing hypothesis"What the FDA actually changed, and when: the November 2025 label update, and what stayed in placeWhat's actually prescribed now versus what WHI tested: bioidentical estradiol and micronized progesterone versus the oral synthetic combination used in the original trial, including how the two progestogens differ at the receptor levelThe hype swing of 2026: what hormone therapy is well-supported for, and what it is notThe new Stanford Alzheimer's study: what its three parts can and cannot tell us, and why the dementia-risk signal from 2003 traces to one specific drug, not to progesterone as a categoryWhat we'd actually tell a patient: an honest, evidence-based bottom lineKey TakeawaysThe WHI's real numbers are absolute, not relative: about 8 additional breast cancer cases per 10,000 women per year in the combined-therapy arm, not the large-sounding relative-risk percentage that made headlines in 2002.Estrogen-alone therapy showed fewer breast cancer cases in the WHI, a reduction that reached statistical significance in longer-term follow-up along with a reduction in breast cancer mortality.Today's typical prescription, transdermal estradiol with micronized progesterone, is a different drug, different route, and different population than what the original WHI tested.A new Stanford study (Neurology, August 2026) found estrogen-only hormone therapy associated with a roughly 35 percent lower likelihood of Alzheimer's pathology markers on autopsy, plus supporting signals in dementia diagnoses and biomarkers. It is observational, not a randomized trial, and it could not address combined therapy either way due to sample size.The dementia-risk signal from the 2003 WHI Memory Study traces specifically to oral conjugated equine estrogen plus medroxyprogesterone acetate, not to progesterone or progestins as a category. Whether the micronized progesterone used today carries the same risk is a genuinely open question, not a settled no.Formulation matters. Ask your provider exactly what you are being prescribed, oral versus transdermal estrogen, and bioidentical micronized progesterone versus a synthetic progestin.Research and Sources MentionedHHS: Advances Women's Health, Removes Misleading FDA Warnings on Hormone Replacement TherapyNPR, August 7, 2026: Everyone's talking about hormone therapy for menopause. Should I be on it?STAT News, January 8, 2026: Hormone therapy for menopause is being overhyped, againStanford Medicine, August 2026: Study ties estrogen-based menopausal hormone therapy to lower Alzheimer's riskNational Cancer Institute: Menopausal Estrogen Therapy Benefits and Risks Vary by Age (WHI analysis)International Menopause Society: Lessons from KEEPS, the Kronos Early Estrogen Prevention StudyShumaker et al., JAMA, 2003: Estrogen Plus Progestin and the Incidence of Dementia and Mild Cognitive Impairment (WHI Memory Study)Barth et al., Lancet Diabetes & Endocrinology, 2023: Sex Steroids and the Female Brain Across the LifespanVinogradova et al., BMJ, 2021: Use of menopausal hormone therapy and risk of dementia (UK QResearch/CPRD cohort)Savolainen-Peltonen et al., BMJ, 2019: Use of Postmenopausal Hormone Therapy and Risk of Alzheimer's Disease in FinlandGleason et al., PLOS Medicine, 2015: Effects of Hormone Therapy on Cognition and Mood (KEEPS-Cognitive and Affective Study)A Note on This EpisodeThis episode is for educational purposes and reflects Dr. Jill and Dr. Ade's read of the current evidence. It is not personalized medical advice. Hormone therapy decisions depend on individual history, and listeners should talk with their own healthcare provider before starting, stopping, or changing any hormone therapy.Connect With UsHave a question about your own hormone therapy, or a topic you want us to cover? Email connect@modernmidlifecollective.com or visit www.modernmidlifecollective.com for links to everything mentioned in this episode.If this episode was useful, follow or subscribe wherever you listen, and consider leaving a rating and review. It genuinely helps other midlife women find the show.
    続きを読む 一部表示
    30 分
  • Episode 40: “Why Can't I Drink Like I Used To? The Truth About Alcohol in Perimenopause”

    Episode 40: “Why Can't I Drink Like I Used To? The Truth About Alcohol in Perimenopause”
    2026/09/02
    One completely ordinary glass of wine.Then suddenly you’re awake at 3 a.m., your heart is racing, you’re hot, your sleep is wrecked, your stomach feels off—and the next morning feels suspiciously like a hangover that should have required a much bigger night out.Sound familiar?In this episode of The Modern Midlife Collective, Dr. Jillian and Dr. Ade explore why many women notice that alcohol affects them differently during perimenopause and menopause.And while hormones are part of the conversation, the answer is much more nuanced than “your estrogen dropped.”Alcohol is landing in a body that may now have different body composition, total body water, sleep architecture, medications, metabolic demands and nervous-system vulnerability—all while estrogen is becoming increasingly unpredictable during the menopause transition.This episode is about recalibration, not perfection.No shame. No judgment. No gold stars for abstinence.Just better information.IN THIS EPISODEDr. Jillian and Dr. Ade discuss:Why alcohol may suddenly feel stronger in midlifeWhy perimenopause is better described as hormonal turbulence than a simple estrogen declineHow alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH2) metabolize alcoholWhy genetic differences can dramatically affect alcohol toleranceHow lower total body water can contribute to higher blood-alcohol concentrationsAge-related changes that may affect the “bounce-back”Why alcohol may make you sleepy while still disrupting restorative sleepREM sleep and those notorious 3 a.m. awakenings“Hangxiety” and the nervous-system rebound after alcoholAlcohol as a potential hot-flash or night-sweat triggerWhy different drinks may feel different—even though ethanol is still ethanolHistamine, sulfites and why red wine may suddenly make some women miserableWhy “red wine is good for your heart” deserves more nuanceAlcohol and breast-cancer riskAlcohol’s effects on appetite, weight-management goals and training recoveryWhat to consider if you are taking a GLP-1 medicationBladder urgency, frequency and menopause-related genitourinary symptomsWhy new medications may change your alcohol toleranceWhat we know—and still don’t know—about alcohol and the gut microbiomeHormonal and evidence-based nonhormonal options for bothersome hot flashes and night sweatsThe Two-Week “Does Alcohol Actually Like Me?” ExperimentKEY TAKEAWAYS1. It probably isn’t just one hormone.Estrogen and alcohol do interact, and research has found associations between alcohol exposure and estradiol levels. But current evidence does not support reducing midlife alcohol intolerance to a simple story in which fluctuating estrogen directly “switches off” ADH or ALDH2.Aging, genetics, body composition, sleep, medications, liver physiology and the menopause transition can all overlap.2. The same drink may be landing in a different body.Alcohol distributes through body water. Changes in body composition with aging—including loss of lean tissue when muscle is not actively preserved—can change the physiologic context in which alcohol is consumed.That is one more reason strength training, protein intake and maintenance of lean mass matter in midlife.3. Being able to “hold your liquor” doesn’t make alcohol harmless.Tolerance describes how intoxicated you feel. It does not mean other physiologic effects disappear.4. Alcohol may help you fall asleep—but that doesn’t make it a sleep treatment.A 2025 systematic review and meta-analysis of 27 studies found that alcohol altered sleep architecture, including delayed REM onset and reduced REM sleep. REM disruption was seen even at relatively low doses and worsened as alcohol intake increased. (PubMed⁠)5. Red wine is not cardiovascular medicine.Some observational studies historically suggested cardiovascular benefits from light-to-moderate alcohol use, but newer analyses have challenged a clear protective effect. The American Heart Association advises people who do not currently drink not to start drinking for health benefits. (professional.heart.org⁠)6. Alcohol and breast-cancer risk deserve an honest conversation.Alcohol is a known human carcinogen. NIAAA currently notes that even approximately one drink per day is associated with a 5% to 15% higher breast-cancer risk compared with women who do not drink.That statistic describes population-level risk. It does not mean one glass of wine “causes” breast cancer in an individual woman. It is information women deserve when deciding what level of alcohol exposure feels acceptable to them. (NIAAA⁠)7. Know what “one drink” actually means.In the United States, one standard drink contains approximately 14 grams of pure alcohol:12 oz regular beer at about 5% ABV5 oz wine at about 12% ABV1.5 oz distilled spirits at about 40% ABVA cocktail, restaurant pour or large home wine glass may contain more than one standard drink. (NIAAA⁠)8. You do not have to simply tolerate ...
    続きを読む 一部表示
    1 時間 4 分
adbl_web_anon_alc_button_suppression_t1
まだレビューはありません