Dr Brecht Ingelbeen and Dr Daniel Valia join Senior Editor Phoebe Hall to discuss a new trial in the journal (the CABU-EICO trial) testing a co-created behavioural intervention bundle to improve antibiotic use, patient management, and water, sanitation and hygiene in rural communities in Burkina Faso and DR Congo. They explain why the study focused on community prescribing (not hospitals), the primary endpoint was a reduction in WHO AWaRE Watch antibiotics (not overall antibiotics), and the intervention targeted all providers of antibiotics in the community, including informal vendors.

Finally, they discuss the importance of designing an intervention bundle that was truly tailored to local context yet practical, sustainable, and scalable beyond the study sites. A parallel study reporting the effect of the intervention bundle on ESBL-producing Escherichia coli colonisation (a co-primary outcome of the trial) is in press at The Lancet Microbe.

To read the full article:

https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(26)00169-6/fulltext

The Lancet Infectious Diseases in conversation with... is part of the Lancet Group podcast offering.

Editorial team: editor-in-chief Ursula Hofer, deputy editor Marco De Ambrogi, and senior editors Syeda Saleha Hassan and Phoebe Hall

Podcast editing: Matteo Simonetti

Visit https://www.thelancet.com/multimedia to learn more about our multimedia offering.

Find the best science for better lives at lancet.com Follow us today at... https://thelancet.bsky.social/ https://instagram.com/thelancetgroup https://facebook.com/thelancetmedicaljournal https://linkedIn.com/company/the-lancet https://youtube.com/thelancettv

Sara Tartof and Matan Yechezkel discuss a new article in The Lancet Infectious Diseases about emerging doxycycline resistance against gonorrhoea and its wider implications for the implementation of doxycycline and the prevention of bacterial sexually transmitted infections.

Click here to read the full article:

https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(26)00123-4/fulltext

The Lancet Infectious Diseases in conversation with... is part of the Lancet Group podcast offering.

Editorial team: editor-in-chief Ursula Hofer, deputy editor Marco De Ambrogi, and senior editors Syeda Saleha Hassan and Phoebe Hall

Podcast editing: Matteo Simonetti

Visit https://www.thelancet.com/multimedia to learn more about our multimedia offering.

Find the best science for better lives at lancet.com Follow us today at... https://thelancet.bsky.social/ https://instagram.com/thelancetgroup https://facebook.com/thelancetmedicaljournal https://linkedIn.com/company/the-lancet https://youtube.com/thelancettv

Dr Jenny Clarke and Herve Semukunzi discuss a study they and colleagues recently published with us titled ‘Infection- and vaccine-induced mpox antibodies: validation of a combined mpox IgG ELISA during the clade 1b outbreak in Rwanda’.

They also discuss the reasons for the paucity of validated serological assays for mpox, particularly in outbreak regions where they are most urgently needed.

Click here to read the full article:

https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(26)00006-X/fulltext

Continue this conversation on social! Follow us today at... https://thelancet.bsky.social/ https://instagram.com/thelancetgroup https://facebook.com/thelancetmedicaljournal https://linkedIn.com/company/the-lancet https://youtube.com/thelancettv

The Lancet Infectious Diseases in conversation with... is part of the Lancet Group podcast offering.

Editorial team: editor-in-chief Ursula Hofer, deputy editor Marco De Ambrogi, and senior editors Syeda Saleha Hassan and Phoebe Hall

Podcast editing: Matteo Simonetti

Visit https://www.thelancet.com/multimedia to learn more about our multimedia offering.

Find the best science for better lives at lancet.com Follow us today at... https://thelancet.bsky.social/ https://instagram.com/thelancetgroup https://facebook.com/thelancetmedicaljournal https://linkedIn.com/company/the-lancet https://youtube.com/thelancettv