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The Lab Beat

The Lab Beat

著者： Cutting-edge science and engineering labs
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The Lab Beat is an award-winning podcast that offers an inside look at cutting-edge science and engineering labs at UC Irvine. Natalie Tso visits the labs, interviews professors and presents their innovations and inspirations in cool short features.

From biomedical engineering, mechanical and aerospace engineering, materials science and engineering, civil and environmental engineering, electrical engineering to computer science, The Lab Beat gives a fascinating look into the newest research at the UC Irvine Samueli School of Engineering.

The Lab Beat won Best Podcast/Audio Storytelling at the 2026 OC Press Awards.

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  • The Female Heart

    The Female Heart
    2026/08/05
    The female heart has been vastly understudied. Naomi Chesler is a leader in researching the female heart and how sex hormones like estrogen affect the heart's function. Her research is helping prevent heart failure in women and men. Naomi Chesler is a UC Irvine professor of biomedical engineering and the director of UC Irvine's Edwards Life Sciences Foundation Cardiovascular Innovation and Research Center. Transcript: [Sound: Heartbeat of Emily Hope, Wikimedia Commons] NATALIE TSO, HOST: That is the heartbeat from a woman named Emily. [Sci fi music] Women's hearts have been historically understudied, and that is a loss not only for women, but men too as the female hormone estrogen could be useful in protecting the heart. Naomi Chesler is a leader in studying female hearts. She is a UC Irvine professor of biomedical engineering and the director of UC Irvine's Edwards Life Sciences Foundation Cardiovascular Innovation and Research Center. She discovered an important contributor to heart failure in women. What got her interested in biomedical engineering? NAOMI CHESLER: When I was a kid, I really enjoyed watching The Six Million Dollar Man, and that was very inspirational for me. I really loved the idea that we could rebuild people and make them stronger. I was also really good at math and science, and I was told when I was a kid that being an engineer was a way to be really creative, using math and science. So then engineering became really appealing to me. I got into the heart because I felt like, you know, we can argue with neuroscientists about this, but I thought it was the most important organ in the body that, you know, you can't really live without a functional heart. And it was a very exciting organ to me. It's got complex mechanical properties and electrical properties, and it drives blood flow that supplies nutrients and oxygen to every cell and tissue in your body. I think that's why I was so intrigued with it. TSO: So why have female hearts been largely understudied? CHESLER: Generations of scientists have been largely male, and those generations of scientists have considered the male the standard and just assume that women would be similar or just a smaller version, the way that folks often assume that children are a smaller version of adults, which is really a very bad assumption. They're very different physiologically, psychologically, you know, hormonal, like just almost in every way. They're not just small adults. And similarly, women are not just small men. TSO: She studies the aspects of the heart that most scientists don't. Right heart failure due to pulmonary hypertension, also known as high blood pressure in the arteries of the lungs. CHESLER: Actually, pulmonary arterial hypertension, which is sort of the analog to systemic hypertension, which is very common, affects four times more women than men and used to be deadly within two to three years and also affect women in their 30s. So here was this disease that affected young women in their reproductive period and was like very quickly deadly. And we knew very little about it. So I started looking at pulmonary hypertension. And as an engineer, I recognized that when arteries are subjected to high pressure for long periods of time, they typically stiffen. And we knew this to be true about the systemic circulation. And I asked the question whether that was true about the pulmonary circulation. And I proved that it was. And I got a lot of “So whats” like “So what if the pulmonary arteries stiffen? The big deal is that the resistance increases.” And it wasn't until a couple of years after I published my findings that a clinical team showed that pulmonary artery stiffness was a better predictor of mortality from pulmonary hypertension than resistance, that people started paying attention. TSO: Chesler’s contribution was key to understanding right heart failure. CHESLER : And now permanent artery stiffness is measured quite frequently in clinical communities, and it's more well recognized that it's a really important contributor to right heart failure. TSO: Roughly 400,000 deaths each year are caused by heart failure in the US, and 15 to 24% of those deaths are due to right heart failure. Now, what is different about the female heart? CHESLER: So the female heart is smaller for sure. Actually, our most recent study shows that in rats there are changes in contractility over the estrous cycle, which is the rat equivalent of a menstrual cycle. I guess that's another reason why females have been excluded from a lot of scientific studies is that any kind of variation in any kind of function over the normal hormonal cycling is considered a source of error or variation. [Sound: EKG] TSO: That's an echocardiogram or EKG. CHESLER: That is the sound of flow through the tricuspid valve in a mouse heart. That's the kind of signal that we analyze to see how the heart is functioning, to see whether the heart functions better or worse with the ...
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    7 分
  • Self-healing Cement

    Self-healing Cement
    2026/06/18
    Mo Li is out to transform the cement industry which creates 8% of the world's carbon emissions. Li has created concrete that can heal itself and a process to produce cement with clean energy. Find out more about her concrete innovations in this episode. Mo Li is a Professor and Chair of the Department of Civil and Environmental Engineering at UC Irvine. TRANSCRIPT: [sound of crane] NATALIE TSO, HOST: That's the sound of a crane in a three-story high lab where they test pillars of cement for earthquake resilience. Concrete is the second most used substance on Earth, after water. And the cement industry creates 8% of the world's carbon emissions. That's why it needs an overhaul. And Mo Li is leading the way. She's a professor and chair of the Department of Civil and Environmental Engineering at UC Irvine. Li wants to make concrete greener and smarter. One of her innovations is making it more like the human body — to be self-healing. MO LI: So self-healing concrete is a concept that how about we transform concrete from a brittle material to a ductile material like metal? But the physics is concrete cannot just be stretched like metal. In order for concrete to be stretched without failure, we designed this very unique damage process into concrete, kind of like a seashell. It actually forms many, many small, tiny cracks hardly seen to human eye. TSO: She explains how she designed her concrete to sense damage and heal its own cracks. LI: To make self-healing happen, we also need to design the chemical composition in the concrete so that once you have a crack, the healing process got naturally actuated. The crack surface will have chemicals exposed to the air and water, and then chemical reaction started. It formed the new ingredients in the crack that fills the crack. TSO: Li is working with California's Department of Transportation. Her lab has already created a concrete bridge slab that has healed itself. LI: So we tested the full scale bridge slab 30 feet long, create the damage. We put it outside in the field conditions, and we proved the cracks are gone. TSO: This technology could have a major impact on the cement industry. LI: We don't need to keep, repair and maintain a concrete bridge deck or pavement. So overall, in terms of life cycle, it becomes more, more sustainable because we end up using less material. TSO: Li is a national leader in self-healing materials, but that's not the only innovation happening in her lab. She also wants to recycle concrete LI: To make concrete, we need to take everything from the earth. Cement you need to take limestone, clay from earth. To make concrete, we not only need cement, we also need sand and rocks. We take all of them from Earth as well. And then we use some water and we use small amount of chemicals. Because a huge volume is involved, there's limited resources on Earth. TSO: But recycling concrete is not easy. LI: It sounds fascinating, but the main challenge is like turning something old into the baby again. So it's against time, against nature Because when cement turns into concrete, there's chemical process there. How do we reverse it? So we can imagine we can crush concrete first, old concrete from demolition site, and then with the smaller pieces, we first ball it into particles. Then we analyze those particles and find out the status composition. [sound of ball mill machine] TSO: That's the sound of the planetary ball mill machine, which helps turn old concrete into powder. The ball mill enables them to control the size of the particles. Then the lab analyzes the powder for its properties and how to reuse it. LI: With that understanding, we can do our magic — the chemical process, electrochemical process. We extract the mineral we want from the old concrete like calcium. We can extract other things like silica. Once we have the process to extract those ingredients out of it, and then we can see how we can return it into a fresh cement. So that's really a cradle to cradle approach. TSO: Her lab has been working with companies like Mitsubishi who supply raw materials. LI: We want to turn it into higher performance materials. So that is the main philosophy we have that is different from the other type of recycling — smartly redesigned into something even better. TSO: Another breakthrough she's made is electrifying the production process of cement so it doesn't use fossil fuels. She and her partner, UCI Professor Iryna Zenyuk, created an electrochemical process powered by clean energy that greatly reduces carbon emissions. They're working with industry to bring their greener process to market. Li’s vision is to transform the cement industry. LI: My ultimate dream is to create a building, a built environment that is more durable, more sustainable and more beautiful. You know, harmony with the natural environment. I think that’s the biggest, most rewarding things civil engineers feel is you go out, you see things you create out there. It ...
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    5 分
  • Revolutionizing Gyroscopes

    Revolutionizing Gyroscopes
    2026/04/23
    Andrei Shkel revolutionized the production of gyroscopes by miniaturizing them and using a glassblowing technology he observed from glass artists in Barcelona, Spain. Step into one of the most high precision gyroscope labs in the world and learn about how they're helping firefighters in this episode. Transcript: [sound of wire bonder] [sci fi music] ELENA WOLGAMOT: This is the wire bonder. This allows us to measure the signals that are coming from the gyroscope, so we can detect the rotation that the sensor is experiencing. NATALIE TSO, HOST: That's Ph.D. student Elena Wolgamot describing a machine in one of the world's most high precision gyroscope labs at UC Irvine. What's a gyroscope? They’re key devices that measure orientation and positioning. They're used in phones, ships, planes and spacecraft to help us stay on course. Most look like a spinning top, but the ones in Andrei Shkel's lab look like wine glasses. Andrei Shkel is a UCI Chancellor's professor of mechanical and aerospace engineering. In 2009, he led a $200 million U.S. Department of Defense national program to miniaturize gyroscopes. He was inspired to make them smaller and more accessible after he saw $1 million gyroscope used in space satellites. ANDREI SHKEL: The highest performance gyroscope ever built. This device is made out of fused quartz, very special device, very expensive, used only on space satellites. In space, there is no GPS and you don't know where you are. So you need some reference. You can use stars, but sometimes stars are not visible. So gyroscopes and accelerometers are really the only sensors that can tell you where you are, your orientation, your position. TSO: It takes three months to make and manually assemble the 96 parts in that hemispheric resonance gyroscope. Shkel revolutionized the production of gyroscopes after an artist in Barcelona, Spain, inspired him. SHKEL: In Barcelona, there is a replica of Spanish Village and where they demonstrate different crafts and this is where I saw this glassblower creating these three dimensional shapes and vases and spheres. TSO: That gave him an idea. SHKEL: Maybe something like this can be done on a micro scale and on a very small scale. I went back and asked one of my students to try it out. Didn't work, didn't work. And then suddenly we were able to make these three dimensional structures, spheres. TSO: Like a glassblower, Shkel uses a furnace of 1,700 degrees Celsius to form glass into wine glass-shaped structures. Researchers line the inside of the structures with a thin layer of metal. Then they bond wire electrodes to the shell to make two millimeter-wide gyroscopes. WOLGAMOT: There's about 15 to 20 steps in the whole process from start to finish, and it's a lot of testing the device, doing another step, testing, seeing if it's better and we're constantly improving our process and seeing how our different steps and making the devices are affecting their performance. [sound of vacuum pump] This is a vacuum pump, so this pulls all of the air out of a chamber. So that way we can test the gyroscopes in a space that has no air. The gyroscopes need to be tested in a space that doesn't have air, because they move so fast and the air slows them down. So it would be like if we were trying to run through honey. These gyroscopes are moving and vibrating so fast it's causing that much resistance for them. So we use this vacuum pump to pull all of the air out of the chamber where we test so then it can move freely and fast and we can sense small rotations. TSO: Shkel’s mini-gyroscopes have been used for autonomous driving, drone navigation, phones and more. Another exciting project they're working on is called NeverLost. It’s for firefighters. SHKEL: When they are on a mission trying to fight fire, they're in a very extreme environment. Environment is so complicated. It's hard. It's almost zero visibility and they don't really have a way to know where people are while they're on a mission. And they said, well, one of the important problem is to develop ability to locate where each first responder is at any point in time. And of course, they’re operating in an environment where it is likely there is no GPS. So what we proposed is to use inertial sensors technology and integrate these inertial sensors in the sole of a shoe. TSO: Graduate student Eudald Rafart explains what they've achieved so far. EUDALD RAFART: We are able to track firefighters within one meter, walking around 20 minutes. Also, part of my research has been developing this Google Maps. It's not just knowing where you are, also it comes with the ability of say, I want to go here inside the building. TSO: Shkel’s NeverLost project won the Innovator Award last year at the National Institute of Standards and Technology. His ultimate dream is to help restore the vestibular system in the inner ear for the elderly, to help them prevent falls. Those are the innovations happening at Andrei Shkel’s Lab ...
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    5 分
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