Dr. Brian Brown is a Professor at the Icahn School of Medicine at Mount Sinai. He discusses how his lab develops innovative technologies to study the immune system and advance new therapeutics, from T cell engineering to mRNA-based medicines. He also explores how microRNA-guided targeting can improve the precision of mRNA therapeutics, how different tissues shape immune responses, and the importance of effective science communication.

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Sindbis in Cerebrospinal Fluid – Scientists have found evidence that Sindbis virus can invade the human central nervous system and cause neurological disease.

A Skin–Lung Reflex – Activation of sensory neurons in the skin suppresses allergic airway inflammation through a vagus nerve–mediated neuroimmune reflex.

Microbiome Enhances Cancer Immunity – Gut bacteria promote anti-tumor immunity by converting tryptophan into indoles that enhance immune responses and inhibit melanoma growth.

Macrophages Drive Healthy Aging – Restoring macrophage clearance of senescent neutrophils reverses age-related decline across multiple organs in mice by blocking EP2 signaling.

Image courtesy of Dr. Brian Brown

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Dr. Andrew Hogan is a Professor and Principal Investigator of the Obesity Immunology Research Group at Maynooth University. He discusses how obesity drives chronic inflammation and immune dysfunction, increasing the risk of diseases such as diabetes and cancer, while highlighting the immune system’s role in disease progression. He also explains how GLP-1 therapies improve both metabolism and immune function, offering new insights into obesity treatment.

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Innate Immunity Predicts Symptoms – Stronger innate immune responses predisposed people to influenza symptoms while also promoting antiviral immune activation.

Broad HIV Neutralization #1 – A novel HIV immunogen induced broadly neutralizing antibodies in macaques, providing a promising blueprint for HIV vaccine development.

Broad HIV Neutralization #2 – A germline-targeting vaccine induced broadly neutralizing HIV antibodies in nonhuman primates.

CAR-T Targets Glioblastoma – A dual-targeting CAR-T therapy achieved durable glioblastoma control in preclinical models.

Image courtesy of Dr. Andrew Hogan

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Dr. Marco Orecchioni is an Assistant Professor at Augusta University. He discusses how olfactory receptors — best known for detecting smells — also function in innate immune cells such as macrophages, where they help sense chemical cues in the tissue environment. He highlights how these receptors regulate inflammation, metabolism, and immune cell behavior in diseases such as atherosclerosis, and explores their potential as novel therapeutic targets.

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Origins of Tumor Macrophages – Tumor-associated myeloid cells arise from distinct circulating monocyte clones with pre-programmed differentiation fates.

DDX6 Restrains Tumor Immunity – DDX6 suppresses dsRNA-driven innate immunity by limiting RNA editing.

Antibody-Directed Xenophagy – TRIM21 directs antibody-bound pathogens into a newly identified autophagy pathway that promotes intracellular pathogen clearance.

RNA Warfare in Plant Immunity – A fungal long non-coding RNA suppresses rice immunity by sequestering a host microRNA.

Image courtesy of Dr. Marco Orecchioni.

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