Dr. Brian Brown is a Professor at the Icahn School of Medicine at Mount Sinai. He discusses how his lab develops innovative technologies to study the immune system and advance new therapeutics, from T cell engineering to mRNA-based medicines. He also explores how microRNA-guided targeting can improve the precision of mRNA therapeutics, how different tissues shape immune responses, and the importance of effective science communication.

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Sindbis in Cerebrospinal Fluid – Scientists have found evidence that Sindbis virus can invade the human central nervous system and cause neurological disease.

A Skin–Lung Reflex – Activation of sensory neurons in the skin suppresses allergic airway inflammation through a vagus nerve–mediated neuroimmune reflex.

Microbiome Enhances Cancer Immunity – Gut bacteria promote anti-tumor immunity by converting tryptophan into indoles that enhance immune responses and inhibit melanoma growth.

Macrophages Drive Healthy Aging – Restoring macrophage clearance of senescent neutrophils reverses age-related decline across multiple organs in mice by blocking EP2 signaling.

Image courtesy of Dr. Brian Brown

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