『The Generalist』のカバーアート

The Generalist

The Generalist

著者: Mario Gabriele
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“The future is already here. It’s just not evenly distributed.” The Generalist Podcast brings you weekly conversations with the people who live in these pockets of the future – visionary founders, prescient investors, and original thinkers. Each episode is designed to introduce you to new ideas, technologies, and markets and help you prepare for the world of tomorrow.Mario Gabriele
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  • 38x in Ten Months: Inside One of Fintech’s Fastest-Growing Infrastructure Companies (Farooq Malik, CEO of Rain)
    2026/08/18

    Farooq Malik is the co-founder and CEO of Rain, a financial infrastructure company powered by stablecoins. Growing up in an immigrant family, Farooq saw firsthand the friction involved in moving money across borders. Alongside co-founder Charles Yoo-Naut, Farooq spent years building infrastructure before stablecoins became mainstream, betting that tokenized money would eventually become a foundational layer of the global financial system. Today, Rain powers card issuance, payments, and other financial products built on stablecoin rails, helping companies move money faster and operate across markets.


    In our conversation, we explore:

    • How stablecoins combine the advantages of cash and electronic money
    • The barriers that still make moving money across borders expensive and inefficient
    • The parallels between being an immigrant and being an entrepreneur
    • How Farooq and Charles met through On Deck and decided to build together
    • What Rain gained by building before the market was ready
    • How Rain earned the trust of early partners who later became customers
    • What The Art of War taught Farooq about patience
    • The misconception that stablecoins are only for emerging markets
    • Why the payments market is big enough for multiple winners
    • Why he believes Rain’s infrastructure is well positioned for a future shaped by AI agents

    Thank you to the partners who make this possible

    Brex: The intelligent finance platform.

    Timestamps

    (00:00) Intro

    (02:46) An overview of Rain and global-first financial infrastructure

    (06:57) The barriers to moving money and how technology can reduce them

    (15:34) How stablecoins behave like cash

    (18:46) The economic opportunity of a more efficient monetary system

    (22:06) How Farooq’s childhood as an immigrant shaped him

    (26:00) Farooq’s first entrepreneurial venture

    (29:11) Lessons from Farooq’s career before founding Rain

    (36:09) Connecting with Charles through On Deck

    (39:51) From Sign and Wire to Rain

    (42:18) Why Rain bet on stablecoins

    (47:25) How a Rain card works

    (49:15) How Rain thinks about its business

    (51:12) Lessons from The Art of War

    (54:30) Rain’s approach to hiring and management

    (55:47) Why the US is a stablecoin hub

    (59:10) Why there’s room for more than Stripe

    (1:03:39)How Farooq and Charles stay aligned with limited meetings

    (1:05:54) Rain’s most critical mantras

    (1:08:56) Why Rain is ready for AI agents

    (1:12:30) Final meditations

    Follow Farooq Malik

    LinkedIn: https://www.linkedin.com/in/fhmalik

    X: https://x.com/rooqster

    Website: https://fhmalik.com

    Resources and episode mentions: https://www.generalist.com/p/38x-in-ten-months-inside-one-of-fintechs

    Production and marketing by penname.co. For inquiries about sponsoring the podcast, email jordan@penname.co.

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    1 時間 15 分
  • AI Got Good at Language. Now It’s Learning the Language of Life. (Eric Nguyen, Co-Founder and CEO of Radical Numerics)
    2026/08/04
    Eric Nguyen is the co-founder and CEO of Radical Numerics, an AI research lab that has raised $50 million to train models directly on biological data. Before starting the company, Eric helped develop Evo and Evo 2, large-scale genome language models trained on unlabeled DNA sequences. Radical Numerics is now building models that can connect information across DNA, RNA, proteins, epigenetics, and other parts of biology, rather than treating each as a separate problem. Researchers have already used Evo to generate viable bacteriophage genomes, and Eric says Radical Numerics’ newer model, Omnii, matched key findings from two years of Alzheimer’s wet-lab research in a matter of days. He also believes these tools could make it easier to create dangerous pathogens, which is why the company is working on both biological design and biodefense.In our conversation, we explore:What AI models can learn by treating DNA as a languageWhy reading scientific papers is not the same as learning directly from biological dataHow Eric’s unusually free-range childhood shaped the way he follows his curiosityWhy biology may have more useful data than researchers know how to useHow Radical Numerics plans to connect information across DNA, RNA, proteins, and other biological systemsWhere the company sees early opportunities in drug discovery, diagnostics, synthetic biology, and biodefenseWhy testing AI-generated biology in the lab is still slow and difficultHow models that design biological systems could also help detect dangerous or manipulated pathogensHow to make powerful biology models safer without eliminating the capabilities that make them valuable—Thank you to the partners who make this possibleAhrefs Brand Radar: Find your brand in AI results.Brex: The intelligent finance platform.Guru: The AI source of truth for work.—Timestamps(00:00) Intro(03:35) An overview of Radical Numerics(06:35) From protein models to modeling all of biology(11:08) Why they started with DNA(15:04) The process of mapping DNA as a language(19:47) What’s unknown, and how we learn from novelty(26:24) The limits of language models in biology(31:15) Eric’s free-range upbringing and path to his PhD program(41:20) Applying long-context models to DNA and meeting his co-founders(46:36) Biology’s untapped data opportunity(49:02) Why biology needs multimodal AI(55:30) How better general LLMs benefit Radical Numerics(57:19) The challenges of biological verification(1:02:05) Making biology more concrete(1:04:51) Radical Numerics’ strategy and early use cases(1:07:26) Balancing safety with capable AI models(1:15:47) What success in biodefense looks like(1:18:09) Final meditations—Follow Eric NguyenLinkedIn: https://www.linkedin.com/in/nguyenstanfordX: https://x.com/exnxWebsite: https://erictnguyen.com—Resources and episode mentions: https://www.generalist.com/p/ai-got-good-at-language-now-its-learning—Production and marketing by penname.co. For inquiries about sponsoring the podcast, email jordan@penname.co.
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    1 時間 22 分
  • Own or Be Owned: Why Every Company Needs Its Own AI Model (Yash Patil, Co-Founder & CEO of Applied Compute)
    2026/06/23

    Yash Patil is the 23-year-old founder and CEO of Applied Compute, a $1.3 billion company helping businesses train custom AI models on their own data: smaller, cheaper, and purpose-built for the work they actually do. Before founding the company, Yash dropped out of Stanford and spent two years at OpenAI working on post-training infrastructure and Codex. He left with one core conviction: every company that runs its critical workflows on someone else’s model is building on shifting sand. Applied Compute is his answer to that problem, already serving customers including DoorDash, Cognition, and Mercor.


    In our conversation, we explore:

    • Why “own or be owned” is becoming existential for any company that relies on frontier AI models
    • What it was like inside OpenAI the weekend the board fired, and then reinstated, its CEO
    • Why post-training is where competitive advantage is now being built, and what reinforcement learning with verifiable rewards actually is
    • Why evals have become the new production environment, and why companies will never share them with frontier providers
    • How a specialized model built for DoorDash outperformed frontier models on a narrow, high-value task
    • Why cost, not capability, is now the primary driver pushing companies toward custom models
    • Why Yash believes AI’s transformation of the economy will unfold over decades, and why near-term fears about mass job displacement are misplaced

    Thank you to the partners who make this possible

    Brex: The intelligent finance platform.

    Guru: The AI source of truth for work.

    Persona: Trusted identity verification for any use case.

    Transcript: https://www.generalist.com/p/own-or-be-owned-why-every-company

    Timestamps

    (00:00) Introduction

    (03:50) Fable 5 and the case for owning your own models

    (09:22) Why Applied Compute is betting on custom AI models

    (12:30) Yash's early influences and first projects

    (17:42) His brief time building at Stanford

    (19:29) Leaving Stanford for OpenAI

    (25:58) Inside OpenAI during Sam Altman's firing

    (28:18) What Yash admires about Sam Altman

    (29:43) Teaching models to reason

    (35:39) The core insight behind Applied Compute

    (39:40) How Applied Compute works with its customers

    (45:55) Why model training never ends

    (48:56) Why not every task needs a frontier model

    (51:25) The culture and people of Applied Compute

    (54:50) Applied Compute's training infrastructure

    (58:43) The coming compute crunch and other predictions

    (1:03:48) Final meditations

    Follow Yash Patil

    X: https://x.com/ypatil125

    Website: https://yashpatil.me

    LinkedIn: https://www.linkedin.com/in/yash-s-patil

    Resources and episode mentions: https://www.generalist.com/p/own-or-be-owned-why-every-company⁠

    Production and marketing by penname.co. For inquiries about sponsoring the podcast, email jordan@penname.co.

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    1 時間 8 分
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