Welcome to the 37th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications.

This episode features a discussion with first author Dr Tobias Moser of the Brain article entitled: Propionic acid in multiple sclerosis: a phase 2b, double-blind, randomized placebo-controlled trial

We discuss the an exciting results...

Check out the full article on the Brain website as part of the July 2026 issue: https://doi.org/10.1093/brain/awag099

This episode was co-hosted, edited and produced by Xin You Tai and Alasdair Coles, co-produced by Xin You Tai and Antonia Johnston, original music by Ammar Al-Chalabi.

Welcome to the 38th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications.

This episode features a discussion with senior author Professor Gültekin Tamgüney of the Brain article entitled: Vaccines mimicking conformational epitopes on α-synuclein fibrils provide immunity to Parkinson's disease

We discuss the an exciting approach of structurally engineering fungal proteins to mimic the specific conformational epitopes of pathological alpha-synuclein fibrils. The authors develop a precise method for inducing targeted immunity against synucleinopathies. In vivo testing demonstrated efficacy, with immunized models achieving up to a 42% extension in survival along with robust antibody recognition of human Parkinson's and Lewy body tissues. This study offers a proof-of-concept for human neurodegenerative disease therapeutics.

Check out the full article on the Brain website as part of the August 2026 issue: https://doi.org/10.1093/brain/awag099

This episode was co-hosted, edited and produced by Michael David and Adam Handel, co-produced by Xin You Tai and Antonia Johnston, original music by Ammar Al-Chalabi.

Welcome to the 36th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications.

This episode features a discussion with senior author Dr Carsten Finke of the Brain article entitled: Brain atrophy patterns in anti-IgLON5 disease

We discuss a fascinating article which examines clinical and imaging data related to anti-Iglon5 disease. This valuable contribution to our understanding of this rare disease comprises data collected across multiple sites. Results identified distinct atrophy patterns in anti-IgLON5 disease, which closely mirror sites of pathophysiologic processes, including autoantibody binding and tau deposition.

Check out the full article on the Brain website as part of the March 2026 issue: https://doi.org/10.1093/brain/awaf256

This episode was co-hosted, edited and produced by Michael and Adam Handel, co-produced by Xin You Tai and Antonia Johnston, original music by Ammar Al-Chalabi.