エピソード

  • Explainable Clinical Digital Twins: One Engine for Power Plants and Patients

    Explainable Clinical Digital Twins: One Engine for Power Plants and Patients
    2026/07/23
    The same software engine can run a 400-megawatt power plant and simulate whether a cancer drug will survive a real-world patient population. That’s not two companies — it’s one engine, built by a founder who came up not in medicine but in gas turbines and heavy industry.In this episode, Dr. Junaid Kalia hosts — with co-hosts Ed Marx and Dr. Harvey Castro — a two-guest conversation with Dr.-Ing. Amir A. Hashmi, founder of Xcelenz and creator of the GENEXIX digital-twin platform, and Dr. Dania Amir, the internal-medicine physician leading its clinical validation. GENEXIX carries an industrial-reliability DNA — traceability, baselines, failure-mode reasoning, “no black-box AI” — from the power plant into the hospital, where the same engine models a patient’s physiology, predicts deterioration, and runs in-silico drug simulations for research. The Signal & Symptoms question: does an industrial mindset actually earn a doctor’s trust at the bedside — and what should a health system ask before it lets a digital twin, especially one born in industry, near a real clinical decision?What You Will Discover:Cold open — one engine, two worlds Welcome + meet the two guests (Amir + Dania) From industry to medicine: Amir’s crossover The physician’s role: Dania on clinical validation Why build a digital twin? (the analogy) The clinical twin: modeling multi-organ physiology Under the hood: explainable architecture In the ICU: where the twin earns its value The stakes + the intelligence layer The future — “don’t surrender to AI, learn AI”Connect with us:Dr. Harvey Castro, ER Physician, #DrGPT™ 💼 LinkedIn — https://www.linkedin.com/in/harveycastromd/ 🔗 Website — https://www.harveycastromd.com/ 📷 Instagram — https://www.instagram.com/harveycastromd/ 📑 Substack — https://harveycastromd.substack.com/Edward Marx, CEO, Advisor💼 LinkedIn — https://www.linkedin.com/in/edwardmarx/ 🔗 Website — https://www.marxadvisory.com/📹 YouTube — https://www.youtube.com/@EdwardMarxDr. Junaid Kalia, Neurocritical Care Specialist and Founder of Savelife.AI™💼LinkedIn - https://www.linkedin.com/in/junaidkaliamd🔗Website - https://www.junaidkalia.com/📹YouTube - https://www.youtube.com/@junaidkaliamdSpecial Guest:Dr.-Ing. Amir A. Hashmi — Founder & Advisor, Xcelenz (creator of the GENEXIX digital-twin platform) 💼 LinkedIn — https://www.linkedin.com/in/amir-a-hashmi-dr-ing-42354113/Dr. Dania Amir — Director of Clinical AI & Internal Medicine Lead, GENEXIX-cDT (MRCP, UK)💼 LinkedIn — https://www.linkedin.com/in/dr-dania-amir-a554208aVisit our website: https://signalandsymptoms.comGet advisory insights about Healthcare AI — at zero cost: https://junaidkaliamd.substack.com/Medical disclaimer: This conversation is for general informational purposes and is not medical advice. Listening does not create a doctor–patient relationship. Always consult a qualified clinician for your child’s care.
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    18 分
  • Who Owns Your Medical Record Now? — Stephen Rouse, Co-Founder, Savva

    Who Owns Your Medical Record Now? — Stephen Rouse, Co-Founder, Savva
    2026/07/09
    For a generation, your medical record has lived behind the hospital’s firewall. What happens the day the patient walks in holding it — already read, already interpreted by AI, on their own phone?In this episode, Dr. Harvey Castro hosts — with co-hosts Ed Marx and Dr. Isha Mannering — a conversation with Stephen Rouse, co-founder and head of growth at Savva, a consumer health app (in beta, launching this summer) built on a single premise: patients should own and understand their own health data. Coming from the enterprise-EHR world, Stephen argues the next shift isn’t inside the hospital system — it’s outside it, in the patient’s hands. The panel works through why the Cures Act cracked the door open, what it means to keep a record on-device instead of the cloud, the everyday mess of five different patient portals, a global bet to reach a billion people without a portal to disrupt — and the hard question no one has fully answered: when a patient shows up already “knowing,” who’s accountable for what the AI surfaced?What You Will Discover:Cold open — “consumers can take over their health information”Meet the panel + Stephen’s Savva one-linerWhy should the patient own the record? (Protocol First → the Cures Act)Your chart, off the hospital’s cloud (on-device + privacy)Why do you have five different portals? (the access problem)A billion people, no portal to disrupt (the global bet)When the patient already knows (the exam-room collision)Who’s accountable if it’s wrong? (the open debate)Closing: what clinicians should do nowReferenced in the show:🖇️ Dr. Harvey Castro’s work on ChatGPT in healthcare — https://www.harveycastromd.com/Connect with us:Dr. Harvey Castro, ER Physician, #DrGPT™ 💼 LinkedIn — https://www.linkedin.com/in/harveycastromd/ 🔗 Website — https://www.harveycastromd.com/ 📷 Instagram — https://www.instagram.com/harveycastromd/ 📑 Substack — https://harveycastromd.substack.com/Edward Marx, CEO, Advisor💼 LinkedIn — https://www.linkedin.com/in/edwardmarx/ 🔗 Website — https://www.marxadvisory.com/📹 YouTube — https://www.youtube.com/@EdwardMarxDr. Isha Mannering — Board-Certified Pediatrician, Founder of InTuneMDLinkedIn — https://linkedin.com/in/drishaSpecial Guest:Stephen Rouse, Co-Founder & Head of Growth, Savva 💼 LinkedIn — https://linkedin.com/in/rousestephenVisit our website: https://signalandsymptoms.comGet advisory insights about Healthcare AI — at zero cost: https://junaidkaliamd.substack.com/Medical disclaimer: This conversation is for general informational purposes and is not medical advice. Listening does not create a doctor–patient relationship. Always consult a qualified clinician for your child’s care.
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    17 分
  • Can Medicine Keep Up with AI? — Dr. Yeshe Kway (Oxford)

    Can Medicine Keep Up with AI? — Dr. Yeshe Kway (Oxford)
    2026/07/02
    Somewhere in Oxford, there’s an AI that can produce a contrast-enhanced cardiac MRI without ever injecting the contrast. No needle, no gadolinium, no risk. It works — and it has for years. Walk into a community hospital in Dallas tomorrow, and you still can’t get it.In this episode, Dr. Harvey Castro hosts — with co-hosts Ed Marx and Dr. Isha Mannering — a conversation with Dr. Yeshe Kway, a medical data scientist in Oxford’s Zhang Group building the AI that reads cardiovascular MRI. Together they take on the question every health-system leader is quietly asking: can medicine actually keep up with AI? They range across what AI can now see inside the whole body, why reactive medicine is giving way to proactive care, the unglamorous economics that strand breakthrough imaging one mile short of the patient, the ethics of telling a healthy child they may get sick someday, whether an employer could one day use AI against you, and a blunt warning about AI “poisoning” the well of medical knowledge.What You Will Discover:Cold open — can medicine keep up?Meet the panel + Yeshe’s path: Germany → Singapore → OxfordWhat can AI actually see inside your whole body?Reactive medicine is dying — what replaces it?It works — so why can’t your hospital use it? (the adoption wall)Should we tell a child they’ll get sick? (pediatric early-risk ethics)Predicting disease from a routine eye scan — and who could use itIs the doctor who won’t use AI already behind?Is AI poisoning medical knowledge?Closing: human + AIReferenced in the show:🖇️ Dr. Harvey Castro’s work on ChatGPT in healthcare — https://www.harveycastromd.com/Connect with us:Dr. Harvey Castro, ER Physician, #DrGPT™ 💼 LinkedIn — https://www.linkedin.com/in/harveycastromd/ 🔗 Website — https://www.harveycastromd.com/ 📷 Instagram — https://www.instagram.com/harveycastromd/ 📑 Substack — https://harveycastromd.substack.com/Edward Marx, CEO, Advisor💼 LinkedIn — https://www.linkedin.com/in/edwardmarx/ 🔗 Website — https://www.marxadvisory.com/📹 YouTube — https://www.youtube.com/@EdwardMarxDr. Isha Mannering — Board-Certified Pediatrician, Founder of InTuneMDLinkedIn — https://linkedin.com/in/drishaSpecial Guest:Dr. Yeshe Kway, Medical Data Scientist, Zhang Group (AI in Cardiovascular Imaging), University of Oxford 💼 LinkedIn — https://www.linkedin.com/in/yeshe-kway-b77b53185/Visit our website: https://signalandsymptoms.com/Get advisory insights about Healthcare AI — at zero cost: https://junaidkaliamd.substack.com/Medical disclaimer: This conversation is for general informational purposes and is not medical advice. Listening does not create a doctor–patient relationship. Always consult a qualified clinician for your child’s care.
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    17 分
  • AI Won’t Replace Your Pediatrician — But It Will Change the Visit

    AI Won’t Replace Your Pediatrician — But It Will Change the Visit
    2026/06/23
    The hardest part of a pediatric visit now happens before the appointment even begins.In this episode, Dr. Isha Mannering — a board-certified pediatrician with 16 years in the Dallas–Fort Worth area and founder of InTuneMD — joins Dr. Junaid Kalia, Dr. Harvey Castro, and Ed Marx to confront a new reality in the exam room: parents arrive having already consulted TikTok and ChatGPT, and the physician’s first job is winning back trust. Drawing on more than a decade in practice and her decision to go independent, Isha makes the case for treating AI as a tool, not a takeover — one that can hand clinicians back their time, sharpen early-warning “signals” in young patients, and bring care into the home. The conversation widens into pediatric AI in practice, the rural-versus-frontier care divide, at-home sick care, and a blunt warning to health systems: enable entrepreneurship within your walls, or be disintermediated by those who will.What You Will Discover:Cold open + welcome (Junaid, Harvey, Ed + Dr. Mannering) Why trust is eroding: the viral-TikTok rare-disease scare AI as a tool: the “healthcare influencer” + scribe & signal Going independent: “figuring it out as I go” Authenticity: earning the trust of parents AND kids “Put the laptop down”: reclaiming the visit Pediatric AI in practice: comic discharge notes + an NFC plushie Catching the signal early: “never trust a newborn” At-home sick care: the 2 a.m. fever The hospital reckoning: adapt or be disintermediated Closing: human + AI — have fun with itReferenced in the show:🖇️ Dr. Harvey Castro’s work on ChatGPT in healthcare — https://www.harveycastromd.com/Connect with us:Dr. Junaid Kalia, Neurocritical Care Specialist and Founder of SaveLife.AI™ 💼 LinkedIn — https://www.linkedin.com/in/junaidkaliamd 🔗 Website — https://www.junaidkalia.com/ 📹 YouTube — https://www.youtube.com/@junaidkaliamdDr. Harvey Castro, ER Physician, #DrGPT™ 💼 LinkedIn — https://www.linkedin.com/in/harveycastromd/ 🔗 Website — https://www.harveycastromd.com/ 📷 Instagram — https://www.instagram.com/harveycastromd/ 📑 Substack — https://harveycastromd.substack.com/Edward Marx, CEO, Advisor💼 LinkedIn — https://www.linkedin.com/in/edwardmarx/ 🔗 Website — https://www.marxadvisory.com/ 📹 YouTube — https://www.youtube.com/@EdwardMarxSpecial Guest:Dr. Isha Mannering, Board-Certified Pediatrician, Founder of InTuneMD 💼 LinkedIn — https://linkedin.com/in/drishaVisit our website: https://signalandsymptoms.com/Get advisory insights about Healthcare AI — at zero cost: https://junaidkaliamd.substack.com/Medical disclaimer: This conversation is for general informational purposes and is not medical advice. Listening does not create a doctor–patient relationship. Always consult a qualified clinician for your child’s care.
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    19 分
  • How Brain Organoids Work (And Why They Could Replace Silicon)

    How Brain Organoids Work (And Why They Could Replace Silicon)
    2026/06/09
    The foundation of tomorrow's diagnostics is being rebuilt — and it starts in biology, not silicon.In this episode, Edmund White, biomedical innovator and bestselling author, joins the conversation to challenge an assumption quietly embedded in every AI tool entering healthcare: that silicon is the only material worth building on. Drawing from three decades at the intersection of cardiac care and medical innovation, Edmund traces a through-line from digital twins of children's hearts to brain organoids — arguing that biology's energy efficiency and adaptability aren't limitations to engineer around, they're the very properties that could unlock earlier intervention and more precise patient outcomes. The conversation widens from there into the economics of AI adoption, the coming bubble, and what it will take for healthcare systems and policymakers to get ahead of a shift that's already in motion.What You Will Discover:- Edmund's Journey From Cardiac Devices to Prevention- Brain Organoids Explained- Silicon vs. Biology: The Hybrid Computing Argument- What Happens When AI is Cheap and Effortless- The Social Impact of AI- Space Computing & Distributed Intelligence- Regulation, Policy, and Germany's Risk Aversion[16:30] Funding Priorities: Where Innovation Dollars Should GoReferenced in the show:🖇️ "AI Today: OI Tomorrow: The Dawn of Organoid Intelligence: Opportunities, Ethics, and the Future of Humanity" – https://www.amazon.com/AI-Today-Tomorrow-Intelligence-Opportunities/dp/1950043584 Connect with us:Dr. Junaid Kalia, Neurocritical Care Specialist and Founder of Savelife.AI™💼LinkedIn - https://www.linkedin.com/in/junaidkaliamd🔗Website - https://www.junaidkalia.com/📹YouTube - https://www.youtube.com/@junaidkaliamdDr. Harvey Castro, ER Physician, #DrGPT™💼LinkedIn - https://www.linkedin.com/in/harveycastromd/🔗Website - https://www.harveycastromd.com/📷Instagram - https://www.instagram.com/harveycastromd/?hl=en📑 Substack - https://harveycastromd.substack.com/Edward Marx, CEO, Advisor💼LinkedIn - https://www.linkedin.com/in/edwardmarx/🔗Website - https://www.marxadvisory.com/📹YouTube - https://www.youtube.com/@EdwardMarxSpecial Guest:Edmund White, VP Business Development & Partnerships, AIBODY💼LinkedIn - https://www.linkedin.com/in/edmund-white-08362ab/🔗Website - https://www.ai2oi.com/Visit our website:https://signalandsymptoms.com/Get advisory insights about Healthcare AI — at zero cost:https://junaidkaliamd.substack.com/
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    19 分
  • Why AI Isn't the Tech Hype Hospital Leaders Think It Is

    Why AI Isn't the Tech Hype Hospital Leaders Think It Is
    2026/06/02

    We built a healthcare system engineered for sick care, but the future of medicine belongs to those who seek health.

    In this episode, global Digital Health Futurist Philippe Gerwill joins the panel to unpack the real bottlenecks stalling clinical innovation. He highlights a critical inversion happening in modern medicine. Historically, technology lagged behind clinical needs. Today, advanced technology vastly outpaces our institutional capacity to adopt it. The conversation delivers an evidence-based perspective on how to manage this rapid acceleration from a global innovator who understands both big pharma infrastructure and the reality of clinical adoption.

    Tune in to discover how forward-thinking medical leaders are realigning systemic incentives to transition from algorithmic task managers back to true, humanist healers.

    What You Will Discover:

    - Intro: The Tech-Adoption Paradox

    - Human Bubble: From Tech Hype To Structural Adaptation

    - What AI and Quantum Convergence Mean for Medicine?

    - The Paradigm Shift from Sick Care to Seeking Health

    - Task Automation vs. Job Displacement

    - Is AI Getting Overwhelming?

    Connect with us:

    Dr. Junaid Kalia, Neurocritical Care Specialist and Founder of Savelife.AI™

    💼LinkedIn - https://www.linkedin.com/in/junaidkaliamd

    🔗Website - https://www.junaidkalia.com/

    📹YouTube - https://www.youtube.com/@junaidkaliamd

    Dr. Harvey Castro, ER Physician, #DrGPT™

    💼LinkedIn - https://www.linkedin.com/in/harveycastromd/

    🔗Website - https://www.harveycastromd.com/

    📷Instagram - https://www.instagram.com/harveycastromd/?hl=en

    📑 Substack - https://harveycastromd.substack.com/

    Edward Marx, CEO, Advisor

    💼LinkedIn - https://www.linkedin.com/in/edwardmarx/

    🔗Website - https://www.marxadvisory.com/

    📹YouTube - https://www.youtube.com/@EdwardMarx

    Special Guest:

    Philippe Gerwill, Digital Healthcare Humanist & Futurist

    💼LinkedIn - https://www.linkedin.com/in/philippegerwill/

    Visit our website:

    https://signalandsymptoms.com/

    Get advisory insights about Healthcare AI — at zero cost:

    https://junaidkaliamd.substack.com/

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    19 分
  • Healthcare AI: What To Know, What's Still Broken, and Where To Go Next

    Healthcare AI: What To Know, What's Still Broken, and Where To Go Next
    2026/05/26
    What does it actually cost when a diagnosis comes six months too late, a test gets ordered twice, or a treatment decision gets made without the best information available?In this special recap episode of Signal & Symptoms, we synthesize the strongest healthcare AI insights from previous episodes — moving from the promise of what AI can do, to the real patient stories that reveal what's at stake when we delay, to an honest look at the barriers still standing in the way, and finally to the path ahead for clinicians and leaders ready to act. This isn't a hype episode. It's a practical reckoning: AI is already changing how diagnoses get made, how patients advocate for themselves, and how the next generation of healthcare standards will be written. The only question is whether you'll help shape it — or watch it happen without you.What You Will Discover:- The Promise: The Tech Exists- The Patient Problem: The Real Cost of Delay- The Reality Check: What the Studies Don't Tell You- Clinician Leadership: Before Someone Else Writes the Rules- The Road Ahead: Act Now or Get Left BehindTune in to the full episodes:🎥https://youtu.be/Vj8JXBkD4OQ (Microsoft AI & Clinical Context)🎥https://youtu.be/yjqhF-coM_w (Patient Delay & Missed Diagnosis)🎥https://youtu.be/vCBOSzMRk-s (Clinician Leadership, Medicine & Dentistry)Referenced in the show:🖇️Blog (2025): The Path to Medical Superintelligence - https://microsoft.ai/new/the-path-to-medical-superintelligence/Connect with us:Dr. Junaid Kalia, Neurocritical Care Specialist and Founder of Savelife.AI™💼LinkedIn - https://www.linkedin.com/in/junaidkaliamd 🔗Website - https://www.junaidkalia.com/ 📹YouTube - https://www.youtube.com/@junaidkaliamd Dr. Harvey Castro, ER Physician, #DrGPT™💼LinkedIn - https://www.linkedin.com/in/harveycastromd/ 🔗Website - https://www.harveycastromd.com/ 📷Instagram - https://www.instagram.com/harveycastromd/?hl=en 📑 Substack - https://harveycastromd.substack.com/ Edward Marx, CEO, Advisor 💼LinkedIn - https://www.linkedin.com/in/edwardmarx/ 🔗Website - https://www.marxadvisory.com/ 📹YouTube - https://www.youtube.com/@EdwardMarx Visit our website:https://signalandsymptoms.com/Get advisory insights about Healthcare AI — at zero cost:https://junaidkaliamd.substack.com/
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    13 分
  • What Hospitals Actually Need Before They'll Deploy Your AI

    What Hospitals Actually Need Before They'll Deploy Your AI
    2026/05/19

    Will AI eliminate primary care — or finally give primary care physicians their time back?

    That's the central question driving this episode, as Dr. Junaid Kalia, Dr. Harvey Castro, and Ed Marx sit down with Dr. John Dayton — an ER physician who has evaluated healthcare startups as an angel investor, built pilots at Intermountain Ventures, and is now raising a $5M fund. He brings a rare view of what AI looks like from the bedside, the boardroom, and the cap table. Dr. Dayton maps how AI decisions actually get made inside health systems: why a technology has to align with the CEO's mission, the CFO's budget, the CTO's existing stack, and clinical staff's real workflow — and why losing any one of those four is where most implementations quietly stall.

    For physicians and healthcare enthusiasts who want to separate signal from noise — and understand whether the tools landing on their unit deserve to be there — this is the peer-to-peer analysis that conference keynotes never deliver.

    What You Will Discover:

    - Intro: John Dayton's origin story

    - Why He Never Really Left Medicine

    - How hospitals actually make AI decisions

    - Is an MBA worth it if it's not free?

    - The Decision Making Approach Inside Health Systems

    - The Two Questions Nobody Answers Directly

    It's not about whether AI is ready for clinical use. It's about whether clinicians are ready to guide patients who are already using it.

    Referenced in the show:

    🖇️ "Professional Development and Upskilling Resources for Clinicians" – https://www.linkedin.com/pulse/professional-development-upskilling-resources-john-dayton-md-mba-xlpmc/

    Connect with us:

    Dr. Junaid Kalia, Neurocritical Care Specialist and Founder of Savelife.AI™

    💼LinkedIn - https://www.linkedin.com/in/junaidkaliamd

    🔗Website - https://www.junaidkalia.com/

    📹YouTube - https://www.youtube.com/@junaidkaliamd

    Dr. Harvey Castro, ER Physician, #DrGPT™

    💼LinkedIn - https://www.linkedin.com/in/harveycastromd/

    🔗Website - https://www.harveycastromd.com/

    📷Instagram - https://www.instagram.com/harveycastromd/?hl=en

    📑 Substack - https://harveycastromd.substack.com/

    Edward Marx, CEO, Advisor

    💼LinkedIn - https://www.linkedin.com/in/edwardmarx/

    🔗Website - https://www.marxadvisory.com/

    📹YouTube - https://www.youtube.com/@EdwardMarx

    Special Guest:

    John Dayton, MD, MBA

    💼LinkedIn - linkedin.com/in/johndaytonmd

    Visit our website:

    https://signalandsymptoms.com/

    Get advisory insights about Healthcare AI — at zero cost:

    https://junaidkaliamd.substack.com/

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    20 分