『Signal and Symptoms Podcast』のカバーアート

Signal and Symptoms Podcast

Signal and Symptoms Podcast

著者： Harvey Castro MD Junaid Kalia MD & Edward Marx
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Three healthcare AI experts who've watched millions wasted on failed projects. Dr. Harvey Castro, Dr. Junaid Kalia, Edward Marx, and guest experts cover all things healthcare AI - from digital transformation to clinical reality. Every Tuesday, we diagnose real failures, reveal what actually works, and help you avoid the expensive mistakes we've seen repeated everywhere. Because when AI decisions affect patient care, getting it right isn't optional.Copyright 2026 Harvey Castro MD, Junaid Kalia MD, & Edward Marx 政治・政府 衛生・健康的な生活 身体的病い・疾患
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  • Explainable Clinical Digital Twins: One Engine for Power Plants and Patients

    Explainable Clinical Digital Twins: One Engine for Power Plants and Patients
    2026/07/23
    The same software engine can run a 400-megawatt power plant and simulate whether a cancer drug will survive a real-world patient population. That’s not two companies — it’s one engine, built by a founder who came up not in medicine but in gas turbines and heavy industry.In this episode, Dr. Junaid Kalia hosts — with co-hosts Ed Marx and Dr. Harvey Castro — a two-guest conversation with Dr.-Ing. Amir A. Hashmi, founder of Xcelenz and creator of the GENEXIX digital-twin platform, and Dr. Dania Amir, the internal-medicine physician leading its clinical validation. GENEXIX carries an industrial-reliability DNA — traceability, baselines, failure-mode reasoning, “no black-box AI” — from the power plant into the hospital, where the same engine models a patient’s physiology, predicts deterioration, and runs in-silico drug simulations for research. The Signal & Symptoms question: does an industrial mindset actually earn a doctor’s trust at the bedside — and what should a health system ask before it lets a digital twin, especially one born in industry, near a real clinical decision?What You Will Discover:Cold open — one engine, two worlds Welcome + meet the two guests (Amir + Dania) From industry to medicine: Amir’s crossover The physician’s role: Dania on clinical validation Why build a digital twin? (the analogy) The clinical twin: modeling multi-organ physiology Under the hood: explainable architecture In the ICU: where the twin earns its value The stakes + the intelligence layer The future — “don’t surrender to AI, learn AI”Connect with us:Dr. Harvey Castro, ER Physician, #DrGPT™ 💼 LinkedIn — https://www.linkedin.com/in/harveycastromd/ 🔗 Website — https://www.harveycastromd.com/ 📷 Instagram — https://www.instagram.com/harveycastromd/ 📑 Substack — https://harveycastromd.substack.com/Edward Marx, CEO, Advisor💼 LinkedIn — https://www.linkedin.com/in/edwardmarx/ 🔗 Website — https://www.marxadvisory.com/📹 YouTube — https://www.youtube.com/@EdwardMarxDr. Junaid Kalia, Neurocritical Care Specialist and Founder of Savelife.AI™💼LinkedIn - https://www.linkedin.com/in/junaidkaliamd🔗Website - https://www.junaidkalia.com/📹YouTube - https://www.youtube.com/@junaidkaliamdSpecial Guest:Dr.-Ing. Amir A. Hashmi — Founder & Advisor, Xcelenz (creator of the GENEXIX digital-twin platform) 💼 LinkedIn — https://www.linkedin.com/in/amir-a-hashmi-dr-ing-42354113/Dr. Dania Amir — Director of Clinical AI & Internal Medicine Lead, GENEXIX-cDT (MRCP, UK)💼 LinkedIn — https://www.linkedin.com/in/dr-dania-amir-a554208aVisit our website: https://signalandsymptoms.comGet advisory insights about Healthcare AI — at zero cost: https://junaidkaliamd.substack.com/Medical disclaimer: This conversation is for general informational purposes and is not medical advice. Listening does not create a doctor–patient relationship. Always consult a qualified clinician for your child’s care.
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    18 分
  • Who Owns Your Medical Record Now? — Stephen Rouse, Co-Founder, Savva

    Who Owns Your Medical Record Now? — Stephen Rouse, Co-Founder, Savva
    2026/07/09
    For a generation, your medical record has lived behind the hospital’s firewall. What happens the day the patient walks in holding it — already read, already interpreted by AI, on their own phone?In this episode, Dr. Harvey Castro hosts — with co-hosts Ed Marx and Dr. Isha Mannering — a conversation with Stephen Rouse, co-founder and head of growth at Savva, a consumer health app (in beta, launching this summer) built on a single premise: patients should own and understand their own health data. Coming from the enterprise-EHR world, Stephen argues the next shift isn’t inside the hospital system — it’s outside it, in the patient’s hands. The panel works through why the Cures Act cracked the door open, what it means to keep a record on-device instead of the cloud, the everyday mess of five different patient portals, a global bet to reach a billion people without a portal to disrupt — and the hard question no one has fully answered: when a patient shows up already “knowing,” who’s accountable for what the AI surfaced?What You Will Discover:Cold open — “consumers can take over their health information”Meet the panel + Stephen’s Savva one-linerWhy should the patient own the record? (Protocol First → the Cures Act)Your chart, off the hospital’s cloud (on-device + privacy)Why do you have five different portals? (the access problem)A billion people, no portal to disrupt (the global bet)When the patient already knows (the exam-room collision)Who’s accountable if it’s wrong? (the open debate)Closing: what clinicians should do nowReferenced in the show:🖇️ Dr. Harvey Castro’s work on ChatGPT in healthcare — https://www.harveycastromd.com/Connect with us:Dr. Harvey Castro, ER Physician, #DrGPT™ 💼 LinkedIn — https://www.linkedin.com/in/harveycastromd/ 🔗 Website — https://www.harveycastromd.com/ 📷 Instagram — https://www.instagram.com/harveycastromd/ 📑 Substack — https://harveycastromd.substack.com/Edward Marx, CEO, Advisor💼 LinkedIn — https://www.linkedin.com/in/edwardmarx/ 🔗 Website — https://www.marxadvisory.com/📹 YouTube — https://www.youtube.com/@EdwardMarxDr. Isha Mannering — Board-Certified Pediatrician, Founder of InTuneMDLinkedIn — https://linkedin.com/in/drishaSpecial Guest:Stephen Rouse, Co-Founder & Head of Growth, Savva 💼 LinkedIn — https://linkedin.com/in/rousestephenVisit our website: https://signalandsymptoms.comGet advisory insights about Healthcare AI — at zero cost: https://junaidkaliamd.substack.com/Medical disclaimer: This conversation is for general informational purposes and is not medical advice. Listening does not create a doctor–patient relationship. Always consult a qualified clinician for your child’s care.
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    17 分
  • Can Medicine Keep Up with AI? — Dr. Yeshe Kway (Oxford)

    Can Medicine Keep Up with AI? — Dr. Yeshe Kway (Oxford)
    2026/07/02
    Somewhere in Oxford, there’s an AI that can produce a contrast-enhanced cardiac MRI without ever injecting the contrast. No needle, no gadolinium, no risk. It works — and it has for years. Walk into a community hospital in Dallas tomorrow, and you still can’t get it.In this episode, Dr. Harvey Castro hosts — with co-hosts Ed Marx and Dr. Isha Mannering — a conversation with Dr. Yeshe Kway, a medical data scientist in Oxford’s Zhang Group building the AI that reads cardiovascular MRI. Together they take on the question every health-system leader is quietly asking: can medicine actually keep up with AI? They range across what AI can now see inside the whole body, why reactive medicine is giving way to proactive care, the unglamorous economics that strand breakthrough imaging one mile short of the patient, the ethics of telling a healthy child they may get sick someday, whether an employer could one day use AI against you, and a blunt warning about AI “poisoning” the well of medical knowledge.What You Will Discover:Cold open — can medicine keep up?Meet the panel + Yeshe’s path: Germany → Singapore → OxfordWhat can AI actually see inside your whole body?Reactive medicine is dying — what replaces it?It works — so why can’t your hospital use it? (the adoption wall)Should we tell a child they’ll get sick? (pediatric early-risk ethics)Predicting disease from a routine eye scan — and who could use itIs the doctor who won’t use AI already behind?Is AI poisoning medical knowledge?Closing: human + AIReferenced in the show:🖇️ Dr. Harvey Castro’s work on ChatGPT in healthcare — https://www.harveycastromd.com/Connect with us:Dr. Harvey Castro, ER Physician, #DrGPT™ 💼 LinkedIn — https://www.linkedin.com/in/harveycastromd/ 🔗 Website — https://www.harveycastromd.com/ 📷 Instagram — https://www.instagram.com/harveycastromd/ 📑 Substack — https://harveycastromd.substack.com/Edward Marx, CEO, Advisor💼 LinkedIn — https://www.linkedin.com/in/edwardmarx/ 🔗 Website — https://www.marxadvisory.com/📹 YouTube — https://www.youtube.com/@EdwardMarxDr. Isha Mannering — Board-Certified Pediatrician, Founder of InTuneMDLinkedIn — https://linkedin.com/in/drishaSpecial Guest:Dr. Yeshe Kway, Medical Data Scientist, Zhang Group (AI in Cardiovascular Imaging), University of Oxford 💼 LinkedIn — https://www.linkedin.com/in/yeshe-kway-b77b53185/Visit our website: https://signalandsymptoms.com/Get advisory insights about Healthcare AI — at zero cost: https://junaidkaliamd.substack.com/Medical disclaimer: This conversation is for general informational purposes and is not medical advice. Listening does not create a doctor–patient relationship. Always consult a qualified clinician for your child’s care.
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    17 分
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