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  • Pablos Holman, Founder, Deep Future, on Why One Blood Test Could Predict What Kills You

    Pablos Holman, Founder, Deep Future, on Why One Blood Test Could Predict What Kills You
    2026/09/10
    Pablos Holman - hacker, Blue Origin alum, co-founder of a 6,000-patent invention lab with Bill Gates and Nathan Myhrvold, and now founder of the venture fund Deep Future - joins Jim Joyce and Eugene Borukhovich for a long-format conversation that starts in an Alaska basement and ends in a proteomic blood test that can already predict what kills you. Along the way: why he coined the term "shallow tech" for the last two decades of Silicon Valley, why the invention labs before his kept under-commercializing their own breakthroughs, and his case for why healthcare needs to work like Amazon and Google Maps combined before any of the rest of it matters. 00:00 - Cold Open - Letting Pablos In02:36 - Why This One's Different: The Long-Format Experiment03:21 - Born in Alaska With a Computer Nobody Had Seen10:23 - The Reverse-Engineering Mantra17:06 - What a Hacker Actually Is26:27 - From Dot-Com Bust to Blue Origin30:29 - Inventing 6,000 Patents With Bill Gates and Nathan Myhrvold36:21 - Why Invention Capital Beats Traditional VC43:49 - The Gwynne Shotwell Problem50:31 - The Case for Paying Inventors Like Musicians54:13 - Healthcare's 18 Trillion Dollar Problem59:11 - Alden Scientific: One Blood Test to Predict What Kills You1:03:12 - The Amazon-and-Google-Maps Vision for Healthcare1:06:40 - 3D-Printed Food, Revisited a Decade Later1:12:35 - Holobiome and the Return of Microbiome Science1:15:26 - AI, Hammers, and Who Should Decide What Matters1:20:33 - The Signature Question: Advice to His Younger Self1:29:05 - Where to Find Pablos Guest: Pablos Holman, Founder, Deep Future - LinkedIn - deepfuture.tech Mentioned in this episode: Blue Origin, Intellectual Ventures, Alden Scientific, Holobiome, Gwynne Shotwell (SpaceX), Neal Stephenson. If you enjoyed this episode, subscribe and leave a review - it's the easiest way to help more people find the show.
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    1 時間 31 分
  • Liana Douillet Guzman, Folx Health, on Why "Willing to Care" for LGBTQ+ Doctor Search Drops 20K to 600

    Liana Douillet Guzman, Folx Health, on Why "Willing to Care" for LGBTQ+ Doctor Search Drops 20K to 600
    2026/09/03
    Liana Douillet Guzman is the CEO of Folx Health, the LGBTQIA+ healthcare platform she almost didn't take the job to run. In this episode, Liana joins Eugene and co-host Marina Berhovic (in for a traveling Jim Joyce) to walk through why 95% of people who come to Folx say they never had an affirming provider before, why the average clinician graduates with roughly five hours of LGBTQIA+-specific training, and why a routine "find a doctor" search can drop from 20,000 providers to 600 once you filter for who is actually willing to treat this community. Liana also traces her own winding path here, through legal tech, crypto, and online education, and gets candid about where she thinks clinical AI is already failing trans patients, including a real case where an AI system recommended conversion therapy. 00:00 - Cold Open - Marina Steps In as Co-Host01:36 - Liana's Origin Story - Puerto Rico to Connecticut07:01 - Falling Into Marketing by Accident10:56 - Ten Years at Axiom, Then COO at Blockchain11:57 - The Call From Folx - Why a Reluctant CEO Said Yes20:35 - The Pediatrician Form That Changed Everything24:54 - What Folx Health Actually Does27:00 - 95 Percent Had No Affirming Provider Before Folx27:19 - Five Hours - The Entire LGBTQIA Medical Curriculum29:00 - From Cash-Pay to Every National Payer33:34 - The Search That Drops 20,000 Doctors to 60039:00 - Ignorant at Scale - AI's Data Problem for Trans Patients42:54 - Why AI-First Health Companies Race to the Bottom43:45 - When AI Recommended Conversion Therapy45:34 - The Shot Question - Advice to Younger Liana Guest: Liana Douillet Guzman, CEO, Folx Health - LinkedIn - folxhealth.com Mentioned in this episode: Marina Berhovic, Lee Shapiro, Kate Steinle (Folx Chief Clinical Officer), Point of Pride, Blue Shield of California. If you enjoyed this episode, subscribe and leave a review - it's the easiest way to help more people find the show.
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    51 分
  • Sean Glynn, Noble on Why an 88% Adoption Rate Proves “Adherence” Was the Wrong Word

    Sean Glynn, Noble on Why an 88% Adoption Rate Proves “Adherence” Was the Wrong Word
    2026/08/20
    Sean Glynn leads patient engagement and evidence programs at Noble, a division of Aptar Pharma. Sean joins Jim Joyce and Eugene to unpack why he thinks medication adherence still isn't solved, and why he'd retire the word "adherence" altogether. His team's SureStart Rx program moved injection training out of doctors' offices and into specialty pharmacy workflows, and the pilot data holds up: 88% patient usage, first doses 3.5 days sooner, and one to two extra doses over six months. Sean also traces the winding path that got him here: organizational behavior grad school, a house-flipping business, pharmacoeconomics at the University of Florida, Health Beacon, and ZS Associates. 00:00 - Cold Open - The Dose Is the Poison02:00 - Meet Sean Glynn - Noble, Aptar, and a Decades-Long Friendship04:00 - Irish Roots and the Family That Reverse-Immigrated Twice09:00 - Delicate Hands to Org Behavior - Finding the Thing13:00 - The Metric Pharma Got Wrong - Commitment Beats Satisfaction18:00 - The Construction Detour, and How Health Beacon Started23:00 - ZS Associates, WHOOP, and the Integrated Evidence Plans26:00 - Dying on the Vine - Why Evidence Plans Get Skipped30:00 - The Noble Pivot - SureStart Rx and the Distribution Problem35:00 - Becoming an Intrapreneur Inside a 9-Billion-Dollar Company38:00 - Why Injections Are Still Genuinely Hard40:00 - The Ozempic Story, Cold Plunges, and Ronaldo's Free Kick44:00 - Killing the Word "Adherence"48:00 - Where Noble Goes Next - AI, Sensors, and Global Expansion50:00 - Closing Question - Advice to His Younger Self Guest: Sean Glynn, Noble / Aptar Pharma - LinkedIn | Noble | Aptar Pharma Mentioned in this episode: Sean McDade and PeopleMetrics, Craig Baker and Jeff Baker (Noble's founders), BioPlus Specialty Pharmacy, WHOOP, ZS Associates, Health Beacon, University of Florida. If you enjoyed this episode, subscribe and leave a review - it's the easiest way to help more people find the show.
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    55 分
  • Jon Anderson, CEO, Nothing Artificial on Why Healthcare Adopts Economic Inevitability

    Jon Anderson, CEO, Nothing Artificial on Why Healthcare Adopts Economic Inevitability
    2026/07/31
    In this episode of #TheShot of Digital Health Therapy, Jim Joyce and I sit down with Jonathan Anderson, CEO of Nothing Artificial. Thoroughly enjoyed reconnecting and chatting across numerous topics: -The Door-to-Door Sales Rule: What Jon learned in his early days of selling home water systems to households (Hint: make sure all the decision makers are present at once) -The Enterprise Arbitrage: How Jon acquired UCB Pharma’s FDA-registered Nile.ai platform turning enterprise infrastructure into a commercial launchpad. -The DTx Graveyard Realist: Why Akili and Pear struggled, and why digital therapeutics must shift from standalone "disease apps" to cognitive infrastructure embedded directly into pharma pipelines and everyday hardware. -Economic Inevitability vs. Hype: Why health systems don't adopt tech because it's novel or slick - they adopt when friction drops to zero and the business model becomes mathematically unavoidable. Ready to hear how real health-tech deals get structured when the PR filter is off? Listen to the full episode on Spotify, Apple Podcasts, or YouTube below (links are in the comments) ! 👇 Fun mentions as always: Pia Clinton-Tarestad, Dominick Kennerson, Anil S Jina, MD , Eddie Martucci, David Benshoof Klein, Cris De Luca ⚽️, William Taranto 00:00:00 - The "Vibe Coded" Shelf & Improv Jazz Strategy 00:03:00 - 12 Siblings, Potato Fields, and the 14-Day Corporate Quit 00:10:30 - The Door-to-Door Water Filter Sales Masterclass 00:17:00 - Buying a Lab Project: 120 Studies, 51 Patents, and Manchester United 00:26:00 - The FDA Regulatory Path: Concussions, MCI, and Biomarkers 00:32:00 - The DTx Graveyard & The Akili Connection 00:41:00 - The $31M UCB Entity: Acquiring Nile.ai 00:46:00 - The 10-Year Horizon: Brain Health as the Next Vital Sign 00:54:00 - The Younger Self Advice: Economic Inevitability vs. Innovation Hype
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    58 分
  • Pia Clinton-Tarestad, Co-Founder & CEO, Clean Slate Clinic on Why Traditional Rehab is a Broken, Fragmented Illusion

    Pia Clinton-Tarestad, Co-Founder & CEO, Clean Slate Clinic on Why Traditional Rehab is a Broken, Fragmented Illusion
    2026/07/16
    In this episode of #TheShot of #DigitalHealth Therapy, Jim Joyce and I sit down with Pia Clinton-Tarestad, CEO of Clean Slate Clinic We poke at the sacred cows of legacy addiction care, the high-touch operational pipes of virtual detox, and the deep cultural stigma that keeps high-functioning corporate leaders suffering in silence. Few topics we discussed: The Anxious Overachiever Trap: Why the high-stakes, competitive "bell-curve" mechanics of consulting and corporate leadership act as a massive incubator for hidden coping mechanisms like alcohol dependence. The Fallacy of the Legacy Inpatient Stay: Why legacy inpatient rehab is highly fragmented and structurally designed for relapse, and how a continuous, 12-month virtual-first support model delivers outcomes that are an order of magnitude better. The Human-in-the-Loop Protocol: Why pure-software wellness apps and low-touch "pill-mill" virtual clinics fail, and how training a patient's immediate personal network (family & friends) creates a scalable, clinical safety net for at-home medical detox. Are we ready to stop funding highly fragmented, low-efficacy options and actually scale real, long-term behavioral recovery? Let us know your thoughts in the comments. Fun mentions as always: Peter Greaney M.D., Dave Sagar 00:00 - The Insider’s Blindspot: From Deloitte Partner to Patient Number One 04:30 - The Anxious Overachiever 09:15 - Why Legacy Rehab is Designed for Relapse 15:45 - The Human-in-the-Loop Protocol: Training Family Members to help with At-Home Medical Detox 21:00 - Bypassing Legacy Codes: Proving the "Hospital Substitution" Arbitrage to Insurers 26:30 - The Pink Nails Effect: Building Trust with the Heavily Stigmatized 28:30 - The Teaser: The Million-Family Blueprint and Charging Toward the Fear
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    45 分
  • Bart De Witte: Why 'Android for Medical AI' is the Only Way to Fix Clinical Innovation

    Bart De Witte: Why 'Android for Medical AI' is the Only Way to Fix Clinical Innovation
    2026/04/17
    In this episode of The Shot of Digital Health Therapy, Jim Joyce and I sit down with Bart De Witte. Bart is a former dentist turned corporate heavyweight (SAP and IBM before becoming a radical advocate for open-source AI. He’s the founder of a non-profit (Hippo AI Foundation) dedicated to freeing medical data and is now building Isaree, a platform aimed at becoming the "Android for Medical Intelligence". -In 1989, a high school Bart wrote that AI would turn doctors into "Super Doctors." -Base Jumping vs. BigCo: Why jumping off a bridge with a parachute is actually the perfect training for navigating the "insane" user interfaces and corporate structures of legacy -Regulatory Capture: How European bureaucracy is accidentally (or intentionally) creating monopolies for West Coast tech giants while stifling local startups. -The Death of the Token: Why the future of healthcare isn't a centralized LLM, but 30 billion parameter models running locally on your phone for "zero tokens" and total privacy. Fun mentions as always: Matthew Holt Indu Subaiya, MD, MBA, MFA Martin Kelly Sean Hogan 00:00:00 - Intro: The Shot of Digital Health Therapy 00:03:00 - Why the Stock Market and French Fries are Actually Belgian 00:05:30 - The 1989 Prophecy: How AI Creates "Super Doctors" 00:08:00 - Base Jumping: The Ultimate Training for High-Stakes Entrepreneurship 00:10:00 - Roasting the SAP "Certified User" Paywall 00:13:00 - From Dentistry to Global Software Innovation 00:17:00 - Vodka Diplomacy: Building Trust and Breaking Spies in Eastern Europe 00:19:00 - Autopsy of a Failure: Why IBM Watson Health Never Stood a Chance 00:22:00 - 240 Flights a Year: The Loneliness of the "Black Card" 00:26:00 - The Open Source Rebellion: Betting Everything on Copyleft 00:32:00 - EU Regulatory Insanity: How the AI Act Stifles Local Innovation 00:37:00 - Digital Feudalism: Why We Need to Fight for Our Language and Thought 00:41:00 - Proximity AI: Running 30B Parameter Models Directly on Your Phone 00:43:00 - The "Last Mile": Why 98% of AI Research Never Helps a Patient 00:48:00 - Advice to a Young Dentist: Neurodivergence is Your Greatest Edge
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    50 分
  • Yang Su & Xing Su: Why the "Tesla Roadster" Strategy is the Only Way to Fix Senior Care

    Yang Su & Xing Su: Why the "Tesla Roadster" Strategy is the Only Way to Fix Senior Care
    2026/03/19
    In this episode of #TheShot of #DigitalHealth Therapy, Jim Joyce and I sit down with Yang Su and Xing Su, co-founders of Seen Health. This is the first time EVER we had twin founders on the show so was fun to find out who actually came out first and what it takes to run a business together. The two brothers were "tech & consultancy royalty", who had never touched a medical record until their own family needed help. Now, they are proving that the biggest innovation in healthcare isn't a new algorithm (though their platform is a key ingredient to scale); it's a "one-stop-shop" center where a doctor, a physical therapist, and a hot meal are all down the same hallway and a community are all a big part of being "seen". The 4 Pillars of the Seen Health Thesis: -The "Roadster" Framework: Why you must start with the $100k-per-year, high-frailty "Roadster" model to build the infrastructure that will eventually drive costs down to $1k-per-month for everyone. -The Operator’s Edge: Why having "outsider" eyes allowed them to see that 70% of senior care is actually logistics, transportation, and nutrition - not just medicine. -The Focus Trap: Why they turned down "easy" revenue from selling their software to stay "unapologetically" focused on the elderly patient in front of them. -Hospitality as Medicine: Borrowing the "Ritz Carlton" philosophy to ensure seniors feel "seen" rather than processed by an institution. Fun mentions as always: Erik Milster, Elon Musk, The Ritz-Carlton Hotel Company, L.L.C., Tesla, Uber, Salesforce, Google, Coursera, Andrew Ng [00:02:40] The 3-Minute Birth Gap: Why being the "older" twin created a lifelong competitive rub. [00:09:00] The "Silicon Valley Dream" vs. Reality: Leaving Google and Stanford's Andrew Ng to find "scars" in the real world. [00:16:10] The Magical Twin Synchronicity: How Uber and Quip were both acquired on the exact same day, charting a course back to each other. [00:18:20] Discovering PACE: Why a 50-year-old model from San Francisco’s Chinatown is still the gold standard. [00:25:20] The San Gabriel Valley Bet: Why they chose hyper-focus over "general" scaling. [00:32:40] The Tesla Roadster Analogy: How to scale high-touch care by driving the "blueprint" cost down from $100k. [00:43:00] The EHR From Scratch: Why they built their own tech stack instead of buying "off the shelf". [00:47:30] The Refusal to Commercialize: Turning down tech revenue to protect the patient experience. [00:51:50] The Closer: "Unapologetically yourself"—advice to their younger twin selves.
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    50 分
  • Carl Byers on the 4 AI Agents of your health & the lessons from taking Athenahealth to IPO

    Carl Byers on the 4 AI Agents of your health & the lessons from taking Athenahealth to IPO
    2026/03/12
    In this episode of #TheShot of #DigitalHealth Therapy, Jim Joyce and I sit down with Carl Bradford Byers 🚑 . Carl is a Partner at F-Prime who was previously CFO of athenahealth and helped scale the company from a basement startup to an IPO. He’s one of the few venture capitalists who actually knows how to build the pipes, not just pitch the vision. What we get into: -The 4 AI Agents of Your Health: How Carl sees the future of agentic AI in health care -The Investment Thesis: Why "smart money" is actually about finding the partner who will sleep in your office to vet the code -The IPO Scars: The reality of scaling to a publicly traded company and the growth mindset (aka survival instinct) required to stay alive. Links to watch / listen below in comments 👇 Fun mentions as always: Daniel Kendall, Marina Borukhovich, Jonathan Bush, Todd Park, Ed Park, Paul Markovich, Chris Dixon, Owen McCarthy, Eric Paley, Brian Roberts, Glen Tullman, John Hallock, Matthew Holt, Indu Subaiya, MD, MBA, MFA [00:02:45] The "Log Cabin" Intro: Carl’s roots and meeting the Athena founding team at Wesleyan. [00:05:30] The War Room: Driving Bill Clinton's van and the intensity of political "advance" work. [00:12:30] The Athena Basement: Why Carl chose a "basement startup" over a prestigious Chicago MBA. [00:16:45] The 4 Pillar Thesis: Breaking down the Clinical, Technical, Financial, and Operational requirements for health-tech. [00:18:45] The Investment Thesis: How Brian Roberts and Venrock vetted the early tech by sleeping in the office. [00:21:00] The President on the Phone: Securing an early $50k from George H.W. Bush. [00:24:00] Scars of the IPO: The transition from a "silly toy" to competing with giants like GE and McKesson. [00:57:00] The Madrid Ad: Why the "Who" is the only thing that survives a 20-year career.
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    59 分