Comedian/writer Alison Leiby (@alisonleiby) joins Jesse, Andy and Matt to talk about her new memoir I'm A Lot, AI promotional scams, chronic back pain, how happiness can literally break your heart, takotsubo octopus traps, a breatkthrough in Alzheimer's-related sleep loss, plaque talk, inhaling CO2 to help with Alzheimer's, debunking the electric pangolin, giraffe math and ranking the intelligence of animals and demons.

Hannah Roeschlein (@handerpumprules) joins Jesse and Matt for half the episode before the computer gods get angry, forcing the two guys to finish the show solo. But between us we talk about Filipino divers! Synthetic cells! And Hobbits and Komodo dragons!

In the Patreon bonus, we get into space fires, and hear how Matt got served by a legendary astronaut and Jesse angered BBQ fans.

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Comedian Kirk Smith (@kirksmithcomedy) joins Jesse, Andy and Matt to talk about his books Rice Krispies with Ketchup and Movin, pools and jacuzzis, competitive eating champions, the science of fireworks, the lack of rap in the Billboard Hot 100 and Andy's upcoming Oregon tour.

Comedian/author Ryan Conner (@ryanconnercomedy) returns to the show to talk with Jesse, Andy and Matt about his new memoir 12 Guys Walk Into a Kitchen, Vietnamese refugees, Tippi Hedren's nail salon legacy, British soccer fans cleaning up in the US, the worst year to be alive, 2020 vs. 1968, hipster nostalgia, stomp clap tall bikes and nuclear (not atomic) clocks.

Zoologist/producer/composer/podcaster Laura Sams (@lauramsams) Jordan joins Jesse, Matt and Andy to talk about fliming grizzly bears in Alaska, studying hyenas in Africa, Laura's kid-friendly wildlife podcast The Happiest Animal Show, starting a production company with your sibling, interviewing six-year-olds, Laura's inflatable basking shark, the shocking actual appearance of basking sharks, the Horniman walrus, they're all in my Wildlife Treasury, a duck in a jersey and inserting a human language gene into mice.

Comedian Diana Hong (@dhongcomedy) joins Jesse, Andy and Matt to discuss cat ownership, Shadow Force, Sawbones and the McElroy-iverse, Diana's golf career, outsider commemorative art, a new way to get your lithium, battery types, alkali metals reacting with water, Lithium Valley, bottle recycling in the US, Sonny Bono's Palm Springs legacy, awful bronze statues, RIP Primm (maybe), an optimal robot body with 20 legs and Old Glory Robot Insurance.

Lawyer-turned-comedian and self-professed podcast slut Charles Star (@ugarles) returns to the show to talk about his podcast No Homework, celebrity roasts, Wings album covers, bad abbreviations, contact lenses that ease depression in mice, the insect with the biggest nuts, self-recognition in beluga whales and the link between sleep duration and accelerated aging.

Comedian and former paramedic James Frey (@jamesfreycomedy) joins Andy, Jesse and Matt to talk about firefighter dreams and emergency medicine reality, James' Ventura comedy show, giving CPR in civilian life, a woman (well, women) who couldn't burp, getting fobbed off, sucker fish hiding in manta rays' butts, a quantum battery breakthrough and missing scientist conspiracy theories.