エピソード

  • Why Enveda Teaches AI to Read Nature's Chemistry

    Why Enveda Teaches AI to Read Nature's Chemistry
    2026/09/09
    Isn’t it crazy to think that half of FDA-approved small molecule drugs have roots in nature? But José Trevejo, Chief Medical Officer at Enveda, says the opportunity now is not to romanticize that history, but to make it usable at modern speed. In this episode of Power to the Patients, Brandon Li speaks with José about AI-assisted drug discovery, mass spectrometry, ENV-294 and why the real bottleneck in biotech may no longer be finding molecules. It may be scaling the trials to test them. By combining ancient healing stories with high-throughput technology, researchers now identify these candidates in hours rather than years. This clinical acceleration is rewriting the early-stage discovery playbook.
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    41 分
  • Reversing Chemo failure in ovarian cancer with Thomas Zindrick

    Reversing Chemo failure in ovarian cancer with Thomas Zindrick
    2026/08/19
    Platinum chemotherapy is the backbone of ovarian cancer treatment. But for far too many patients, it eventually stops working. In this episode of Power to the Patients, Brandon Li sits down with Thomas Zindrick, CEO and President of Genelux Corporation, to discuss Olvi-Vec, platinum resensitization, and why oncolytic virus therapy could give clinicians a new way to work with existing cancer treatments. Platinum resistance is one of the hardest questions to solve in clinical oncology, but some answers are beginning to emerge.
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    38 分
  • The Gout Narrative Keeping Patients Sick and What Crystalys Therapeutics Is Doing Differently

    The Gout Narrative Keeping Patients Sick and What Crystalys Therapeutics Is Doing Differently
    2026/07/23
    Most people still think gout is a lifestyle condition caused primarily by diet. But this belief is a big reason patients have been underserved for decades. In this episode of Power to the Patients, Brandon Li sits down with James Mackay, CEO and co-founder of Crystalys Therapeutics, to explore what gout patients really need. They unpack what went wrong with Zurampic, why Dotinurad’s profile gives Crystalys Therapeutics a reason to come back to gout and how better trial design could finally move the field beyond old assumptions. For decades, gout has often been framed as a disease caused by lifestyle choices. This episode reframes the conversation entirely.
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    36 分
  • Developing a treatment for Alzheimer's in the world of AI with Sacha Schermerhorn

    Developing a treatment for Alzheimer's in the world of AI with Sacha Schermerhorn
    2026/07/07
    Learn about clinical trial design for small molecule therapies using biomarkers in Alzheimer's research and AI in drug development. Brandon Li talks with Sacha Schermerhorn, Founder and CEO of Babylon Biosciences. They discuss why the industry needs to rethink disease pathology, how to recruit elite talent out of retirement, and the role of fine-tuned AI models in predicting clinical outcomes for patients.
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    34 分
  • How Neuroplasticity Is Shaping the Next Generation of Psychiatric Medicines

    How Neuroplasticity Is Shaping the Next Generation of Psychiatric Medicines
    2026/05/13
    Dr. Aaron Koenig, Chief Medical Officer at Delix Therapeutics, sheds light on a new class of medicines designed to promote neuroplasticity without the hallucinogenic effects associated with psychedelics. On this episode of Power to the Patients, Koenig explains to host Brandon Li how neuroplasticogens could provide scalable treatments for depression and other serious brain disorders, why separating plasticity from psychedelic experiences matters for clinical development, and how emerging biomarkers such as qEEG may help measure brain changes in patients. The conversation spans scientific rationale, clinical challenges, and long term potential of plasticity-based therapeutics in psychiatry and neurology.
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    34 分
  • 70% Remission for Postpartum Depression? The Psychedelic Breakthrough

    70% Remission for Postpartum Depression? The Psychedelic Breakthrough
    2026/04/30
    Postpartum depression treatment advances with psychedelic therapy. Greg Mayes of Reunion Neuroscience discusses luvesilocin drug development. This episode explores how shorter-acting psilocybin analogs offer new hope for mothers. Greg highlights the success of the RECONNECT study and the path to FDA breakthrough designation.
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    36 分
  • Why Psychiatry Is Finally Breaking Free From Dopamine

    Why Psychiatry Is Finally Breaking Free From Dopamine
    2026/04/15
    In this episode of Power to the Patients, host Brandon Li sits down with Ken Kramer, PhD, Vice President and Head of Neuropsychiatry Medical Affairs at Bristol Myers Squibb, to explore why psychiatry has lagged behind other therapeutic areas and what’s finally changing. Kramer explains how decades of reliance on dopamine-based antipsychotics shaped treatment, and why new mechanisms like muscarinic agonism are opening the door to safer, more effective options for patients with schizophrenia.
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    29 分
  • Precision Medicine Got Kidney Disease Wrong—Until Now

    Precision Medicine Got Kidney Disease Wrong—Until Now
    2026/04/01
    Explore how variant functionalization is driving the future of mechanism-driven medicines as host Brandon interviews Jason Coloma, CEO of Maze Therapeutics, on Power to the Patients. Jason explains why most gene-disease associations fail to become therapies, how APOL1-mediated kidney disease reveals the power of precision nephrology, and what it actually takes to build an integrated genetics-to-drug-discovery platform.
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    42 分