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  • The Gout Narrative Keeping Patients Sick and What Crystalys Therapeutics Is Doing Differently

    The Gout Narrative Keeping Patients Sick and What Crystalys Therapeutics Is Doing Differently
    2026/07/23
    Most people still think gout is a lifestyle condition caused primarily by diet. But this belief is a big reason patients have been underserved for decades. In this episode of Power to the Patients, Brandon Li sits down with James Mackay, CEO and co-founder of Crystalys Therapeutics, to explore what gout patients really need. They unpack what went wrong with Zurampic, why Dotinurad’s profile gives Crystalys Therapeutics a reason to come back to gout and how better trial design could finally move the field beyond old assumptions. For decades, gout has often been framed as a disease caused by lifestyle choices. This episode reframes the conversation entirely.
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    36 分
  • Developing a treatment for Alzheimer's in the world of AI with Sacha Schermerhorn

    Developing a treatment for Alzheimer's in the world of AI with Sacha Schermerhorn
    2026/07/07
    Learn about clinical trial design for small molecule therapies using biomarkers in Alzheimer's research and AI in drug development. Brandon Li talks with Sacha Schermerhorn, Founder and CEO of Babylon Biosciences. They discuss why the industry needs to rethink disease pathology, how to recruit elite talent out of retirement, and the role of fine-tuned AI models in predicting clinical outcomes for patients.
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    34 分
  • How Neuroplasticity Is Shaping the Next Generation of Psychiatric Medicines

    How Neuroplasticity Is Shaping the Next Generation of Psychiatric Medicines
    2026/05/13
    Dr. Aaron Koenig, Chief Medical Officer at Delix Therapeutics, sheds light on a new class of medicines designed to promote neuroplasticity without the hallucinogenic effects associated with psychedelics. On this episode of Power to the Patients, Koenig explains to host Brandon Li how neuroplasticogens could provide scalable treatments for depression and other serious brain disorders, why separating plasticity from psychedelic experiences matters for clinical development, and how emerging biomarkers such as qEEG may help measure brain changes in patients. The conversation spans scientific rationale, clinical challenges, and long term potential of plasticity-based therapeutics in psychiatry and neurology.
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    34 分
  • 70% Remission for Postpartum Depression? The Psychedelic Breakthrough

    70% Remission for Postpartum Depression? The Psychedelic Breakthrough
    2026/04/30
    Postpartum depression treatment advances with psychedelic therapy. Greg Mayes of Reunion Neuroscience discusses luvesilocin drug development. This episode explores how shorter-acting psilocybin analogs offer new hope for mothers. Greg highlights the success of the RECONNECT study and the path to FDA breakthrough designation.
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    36 分
  • Why Psychiatry Is Finally Breaking Free From Dopamine

    Why Psychiatry Is Finally Breaking Free From Dopamine
    2026/04/15
    In this episode of Power to the Patients, host Brandon Li sits down with Ken Kramer, PhD, Vice President and Head of Neuropsychiatry Medical Affairs at Bristol Myers Squibb, to explore why psychiatry has lagged behind other therapeutic areas and what’s finally changing. Kramer explains how decades of reliance on dopamine-based antipsychotics shaped treatment, and why new mechanisms like muscarinic agonism are opening the door to safer, more effective options for patients with schizophrenia.
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    29 分
  • Precision Medicine Got Kidney Disease Wrong—Until Now

    Precision Medicine Got Kidney Disease Wrong—Until Now
    2026/04/01
    Explore how variant functionalization is driving the future of mechanism-driven medicines as host Brandon interviews Jason Coloma, CEO of Maze Therapeutics, on Power to the Patients. Jason explains why most gene-disease associations fail to become therapies, how APOL1-mediated kidney disease reveals the power of precision nephrology, and what it actually takes to build an integrated genetics-to-drug-discovery platform.
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    42 分
  • Why Dr. Ken Sharlin Believes Most Neurological Diseases Are Reversible

    Why Dr. Ken Sharlin Believes Most Neurological Diseases Are Reversible
    2026/03/18
    In this episode of Power to the Patients, host Brandon Li sits down with Dr. Ken Sharlin, neurologist, researcher, and clinical trial investigator, to explore how precision medicine, functional neurology, and emerging technologies are redefining what’s possible in neurodegenerative disease care. Dr. Sharlin challenges the traditional disease-centered model and shares why restoring biological balance - rather than simply managing symptoms, may unlock new pathways for prevention, reversal, and personalized treatment in conditions like MS, Alzheimer’s, and Parkinson’s.
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    38 分
  • Why Serotonin Isn’t Outdated, Our Thinking Is

    Why Serotonin Isn’t Outdated, Our Thinking Is
    2026/03/11
    In this episode of Power to the Patients, host Brandon Li sits down with Dr. Jacob Jacobsen, neuroscientist and CEO of Evecxia Therapeutics, to challenge some of psychiatry’s most deeply held assumptions. Dr. Seld explains why clinical novelty, not mechanistic novelty, is what truly matters to patients, and how amplifying serotonin synthesis may offer a safer, more scalable path forward for treating depression and OCD.
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    41 分