In this episode Editor-in-Chief Dr. Sadis Matalon (University of Alabama Birmingham) interviews author Dr. Sophia N. Karagiannis (King’s College London) about the recently published Review article by Cheung et al. The authors review the latest research into antibody-drug conjugates (ADCs), referred to as “magic bullets” that kill cancer cells with minimal damage to healthy tissue. What are the main obstacles to manufacturing ADCs and can they be used to treat all types of cancer? Listen now to find out.

Anthony Cheung, Yi Liu, Alicia M. Chenoweth, Hanieh Montaseri, Benjamina Esapa, Vijay Chudasama, James R. Baker, David E. Thurston, and Sophia N. Karagiannis Antibody-drug conjugate design and mechanisms of action for cancer treatment: state of the art and beyond Physiological Reviews, published April 20, 2026. DOI: 10.1152/ physrev.00039.2025

In this episode Associate Editor Dr. Hilary Critchley (University of Edinburgh) and Editor-in-Chief Dr. Sadis Matalon (University of Alabama Birmingham) interview author Dr. Serdar Bulun (Northwestern University) about the recently published Review article by Bulun et al. on the critically important topic of uterine fibroids. Listen as we shed light on this underrecognized and under researched topic in women’s health.

Serdar E. Bulun, Ping Yin, JianJun Wei, Azna Zuberi, Takashi Iizuka, Takuma Suzuki, Priyanka Saini, Jyoti Goad, J. Brandon Parker, Mazhar Adli, Thomas Boyer, Debabrata Chakravarti, and Aleksandar Rajkovic Uterine Fibroids Physiological Reviews, published June 13, 2025. DOI: 10.1152/physrev.00010.2024

In this episode Editor-in-Chief Dr. Sadis Matalon (University of Alabama Birmingham) interviews author Dr. Laura Crotty Alexander (University of California, San Diego) about the recently published Review article by Masso-Silva et al. on the impact of e-cigarette vaping on the immune system across the body. We discuss in depth how vaping limits the ability of alveolar macrophages to protect the body from pathogens, and cover the impact of vaping on T cells, the powerhouse cells of adaptive immunity, to respond robustly to tumor antigens. Does vaping impact the rate of tumor growth in cancer patients, particularly breast cancer and prostate cancer? Listen now to learn much more.

Jorge A. Masso-Silva, Alexia Perryman, Sophia Karandashova, Avnee Jaya Kumar, Laura Barnes, Nikita Kasaraneni, and Laura E. Crotty Alexander Impact of e-cigarette vaping on the immune system across the body Physiological Reviews, published January 24, 2026. DOI: 10.1152/physrev.00011.2025