エピソード

  • Ibogaine: Miracle Cure or Medical Gamble? The Truth Behind a Controversial Psychedelic

    Ibogaine: Miracle Cure or Medical Gamble? The Truth Behind a Controversial Psychedelic
    2026/04/20
    This episode explores ibogaine as a controversial psychedelic treatment for addiction, examining its reported effects on opioid withdrawal, cravings, and psychological insight alongside serious cardiac and neurological risks. It provides a balanced, evidence-based analysis of ibogaine research, including limitations such as lack of randomized trials, selection bias, and short-term outcome data. Ideal for listeners interested in addiction science, mental health innovation, neuroscience, and the risks and promise of emerging psychedelic therapies.
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    7 分
  • Low-Dose Methamphetamine Neuroprotection: What the Studies Actually Show

    Low-Dose Methamphetamine Neuroprotection: What the Studies Actually Show
    2026/04/20
    3 分
  • The Messy Truth About Antidepressants: Benefits, Risks, and the Limits of the Evidence

    The Messy Truth About Antidepressants: Benefits, Risks, and the Limits of the Evidence
    2026/04/19
    Antidepressants demonstrate modest but real benefits for moderate-to-severe depression, with large meta-analyses showing consistent advantages over placebo and meaningful improvements in function for many patients, yet these gains are often smaller than portrayed and heavily influenced by high placebo responses.
The evidence base comes with important limitations, including publication bias, short trial durations, industry influence, and challenges in blinding, which can inflate perceived efficacy while understating long-term risks such as sexual dysfunction, emotional blunting, and weight gain reported more frequently in real-world surveys.
Navigating antidepressants requires pragmatic humility: they are a valuable tool for the right person at the right time when used with careful monitoring, deprescribing when appropriate, and combined with therapy and lifestyle changes, rather than as a one-size-fits-all solution or something to fear outright.
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    9 分
  • Why One ADHD Medication Hits Kids So Differently — And How Genetics Can Help

    Why One ADHD Medication Hits Kids So Differently — And How Genetics Can Help
    2026/04/11
    2 分
  • Artificial intelligence begins prescribing medications in Utah

    Artificial intelligence begins prescribing medications in Utah
    2026/01/06
    2 分
  • Marijuana and emphysema

    Marijuana and emphysema
    2025/10/19
    2 分
  • Ketamine and neurotoxicity

    Ketamine and neurotoxicity
    2025/09/28
    2 分
  • New study on lithium

    New study on lithium
    2025/09/14
    2 分