Neurotransmitter-informed connectivity maps and predicting stroke functional outcome
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Neurotransmitter-informed connectivity maps and predicting stroke functional outcome
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Welcome to the 32th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications.
This episode features a discussion with first author Dr Philipp J Koch of the Brain article entitled: Neurotransmitter-informed connectivity maps and their application for outcome inference after stroke
We discuss a fascinating method to map neurotransmitter-informed brain network maps. From here, the authors examine two separate stroke cohorts and examine the degree of lesion-related disruption of these neurotransmitter connectomes. Of note, disproportionately high damage to dopamine-transporter–weighted networks consistently predicted worse functional recovery. This may lead to exciting therapeutic avenues.
Check out the full article on the Brain website as part of the November 2025 issue: https://doi.org/10.1093/brain/awaf185
This episode was co-hosted, edited and produced by Michael and Adam Handel, co-produced by Xin You Tai and Antonia Johnston, original music by Ammar Al-Chalabi.